Tags

Type your tag names separated by a space and hit enter

Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder.
Cancer Res. 1989 Feb 15; 49(4):1067-70.CR

Abstract

We have developed a highly sensitive sandwich enzyme immunoassay for determination of urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) antigen levels in extracts of human tissues. We determined antigen levels of PAs in extracts of 31 primary cancers and 15 normal mucosal tissues of the urinary bladder using this method. U-PA antigen levels in extracts of bladder cancers were significantly higher than those in normal tissues (p less than 0.005). U-PA antigen levels significantly increased as histological grading of malignancy advanced. There was no correlation between t-PA antigen level and malignancy. These results indicate that an increase of u-PA antigen level may be a parameter of malignant transformation and may play an important role in invasiveness of cancer.

Authors+Show Affiliations

First Department of Pathology, Miyazaki Medical College, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2492205

Citation

Hasui, Y, et al. "Comparative Study of Plasminogen Activators in Cancers and Normal Mucosae of Human Urinary Bladder." Cancer Research, vol. 49, no. 4, 1989, pp. 1067-70.
Hasui Y, Suzumiya J, Marutsuka K, et al. Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder. Cancer Res. 1989;49(4):1067-70.
Hasui, Y., Suzumiya, J., Marutsuka, K., Sumiyoshi, A., Hashida, S., & Ishikawa, E. (1989). Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder. Cancer Research, 49(4), 1067-70.
Hasui Y, et al. Comparative Study of Plasminogen Activators in Cancers and Normal Mucosae of Human Urinary Bladder. Cancer Res. 1989 Feb 15;49(4):1067-70. PubMed PMID: 2492205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder. AU - Hasui,Y, AU - Suzumiya,J, AU - Marutsuka,K, AU - Sumiyoshi,A, AU - Hashida,S, AU - Ishikawa,E, PY - 1989/2/15/pubmed PY - 1989/2/15/medline PY - 1989/2/15/entrez SP - 1067 EP - 70 JF - Cancer research JO - Cancer Res VL - 49 IS - 4 N2 - We have developed a highly sensitive sandwich enzyme immunoassay for determination of urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) antigen levels in extracts of human tissues. We determined antigen levels of PAs in extracts of 31 primary cancers and 15 normal mucosal tissues of the urinary bladder using this method. U-PA antigen levels in extracts of bladder cancers were significantly higher than those in normal tissues (p less than 0.005). U-PA antigen levels significantly increased as histological grading of malignancy advanced. There was no correlation between t-PA antigen level and malignancy. These results indicate that an increase of u-PA antigen level may be a parameter of malignant transformation and may play an important role in invasiveness of cancer. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/2492205/Comparative_study_of_plasminogen_activators_in_cancers_and_normal_mucosae_of_human_urinary_bladder_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=2492205 DB - PRIME DP - Unbound Medicine ER -