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Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis.
Ann Rheum Dis. 2015 Nov; 74(11):1976-82.AR

Abstract

OBJECTIVE

To determine candidate lesion-based criteria for a positive sacroiliac joint (SIJ) MRI based on bone marrow oedema (BMO) and/or erosion in non-radiographic axial spondyloarthritis (nr-axSpA); to compare the performance of lesion-based criteria with global evaluation by expert readers.

METHODS

Two independent cohorts A/B of 69/88 consecutive patients with back pain aged ≤50 years, with median symptom duration 1.3/10.0 years, were referred for suspected SpA (A) or acute anterior uveitis plus back pain (B). Patients were classified according to rheumatologist expert opinion based on clinical examination, pelvic radiography and laboratory values as having nr-axSpA (n=51), ankylosing spondylitis (n=34) or non-specific back pain (n=72). Four blinded readers assessed SIJ MRI, recording the presence/absence of SpA by concomitant global evaluation of T1-weighted spin echo (T1SE) and short τ inversion recovery (STIR) scans and, thereafter, whether BMO and/or erosion were present/absent in each SIJ quadrant of each MRI slice. We derived candidate lesion-based criteria based on the number of SIJ quadrants with BMO and/or erosion and calculated mean sensitivity and specificity for SpA.

RESULTS

For both cohorts A/B, global assessment showed high specificity (0.95/0.83) compared with the Assessment in SpondyloArthritis international Society (ASAS) definition (0.76/0.74). BMO ≥3 (0.89/0.84) or ≥4 (0.92/0.87) showed comparably high specificity to global assessment. Erosion ≥2 and/or BMO ≥3 or ≥4 were associated with comparably high sensitivity to global assessment without affecting specificity. These combined criteria showed both higher sensitivity and specificity than the ASAS definition.

CONCLUSIONS

Lesion-based criteria for a positive SIJ MRI based on both BMO and/or erosion performed best for classification of axial SpA, reflecting the contextual information provided by T1SE and STIR sequences.

Authors+Show Affiliations

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada Department of Rheumatology, Balgrist University Hospital, Zurich, Switzerland.Copenhagen Center for Arthritis Research, Center for Rheumatology and Spinal Diseases, University of Copenhagen, Copenhagen, Denmark.Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.Copenhagen Center for Arthritis Research, Center for Rheumatology and Spinal Diseases, University of Copenhagen, Copenhagen, Denmark.Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada.Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.Rufibach rePROstat, Biostatistical Consulting and Training, Basel, Switzerland.Department of Rheumatology, PLA General Hospital, Beijing, China.Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24925836

Citation

Weber, Ulrich, et al. "Candidate Lesion-based Criteria for Defining a Positive Sacroiliac Joint MRI in Two Cohorts of Patients With Axial Spondyloarthritis." Annals of the Rheumatic Diseases, vol. 74, no. 11, 2015, pp. 1976-82.
Weber U, Østergaard M, Lambert RG, et al. Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis. Ann Rheum Dis. 2015;74(11):1976-82.
Weber, U., Østergaard, M., Lambert, R. G., Pedersen, S. J., Chan, S. M., Zubler, V., Rufibach, K., Zhao, Z., & Maksymowych, W. P. (2015). Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis. Annals of the Rheumatic Diseases, 74(11), 1976-82. https://doi.org/10.1136/annrheumdis-2014-205408
Weber U, et al. Candidate Lesion-based Criteria for Defining a Positive Sacroiliac Joint MRI in Two Cohorts of Patients With Axial Spondyloarthritis. Ann Rheum Dis. 2015;74(11):1976-82. PubMed PMID: 24925836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis. AU - Weber,Ulrich, AU - Østergaard,Mikkel, AU - Lambert,Robert G W, AU - Pedersen,Susanne J, AU - Chan,Stanley M, AU - Zubler,Veronika, AU - Rufibach,Kaspar, AU - Zhao,Zheng, AU - Maksymowych,Walter P, Y1 - 2014/06/12/ PY - 2014/02/13/received PY - 2014/05/25/accepted PY - 2014/6/14/entrez PY - 2014/6/14/pubmed PY - 2016/1/13/medline KW - Ankylosing Spondylitis KW - Magnetic Resonance Imaging KW - Spondyloarthritis SP - 1976 EP - 82 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 74 IS - 11 N2 - OBJECTIVE: To determine candidate lesion-based criteria for a positive sacroiliac joint (SIJ) MRI based on bone marrow oedema (BMO) and/or erosion in non-radiographic axial spondyloarthritis (nr-axSpA); to compare the performance of lesion-based criteria with global evaluation by expert readers. METHODS: Two independent cohorts A/B of 69/88 consecutive patients with back pain aged ≤50 years, with median symptom duration 1.3/10.0 years, were referred for suspected SpA (A) or acute anterior uveitis plus back pain (B). Patients were classified according to rheumatologist expert opinion based on clinical examination, pelvic radiography and laboratory values as having nr-axSpA (n=51), ankylosing spondylitis (n=34) or non-specific back pain (n=72). Four blinded readers assessed SIJ MRI, recording the presence/absence of SpA by concomitant global evaluation of T1-weighted spin echo (T1SE) and short τ inversion recovery (STIR) scans and, thereafter, whether BMO and/or erosion were present/absent in each SIJ quadrant of each MRI slice. We derived candidate lesion-based criteria based on the number of SIJ quadrants with BMO and/or erosion and calculated mean sensitivity and specificity for SpA. RESULTS: For both cohorts A/B, global assessment showed high specificity (0.95/0.83) compared with the Assessment in SpondyloArthritis international Society (ASAS) definition (0.76/0.74). BMO ≥3 (0.89/0.84) or ≥4 (0.92/0.87) showed comparably high specificity to global assessment. Erosion ≥2 and/or BMO ≥3 or ≥4 were associated with comparably high sensitivity to global assessment without affecting specificity. These combined criteria showed both higher sensitivity and specificity than the ASAS definition. CONCLUSIONS: Lesion-based criteria for a positive SIJ MRI based on both BMO and/or erosion performed best for classification of axial SpA, reflecting the contextual information provided by T1SE and STIR sequences. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/24925836/Candidate_lesion_based_criteria_for_defining_a_positive_sacroiliac_joint_MRI_in_two_cohorts_of_patients_with_axial_spondyloarthritis_ L2 - https://ard.bmj.com/cgi/pmidlookup?view=long&pmid=24925836 DB - PRIME DP - Unbound Medicine ER -