Tags

Type your tag names separated by a space and hit enter

[Diagnosis and differential diagnosis of anti-N-methyl-D-aspartate receptor encephalitis in children].
Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jun; 16(6):578-83.ZD

Abstract

Autoimmune encephalitis is rare and has various clinical manifestations, which may hamper the correct diagnosis. Therefore, the pediatrician should be familiar with the clinical symptoms, signs, laboratory features, neuroimaging changes, immunological characteristics, and differential diagnosis of this disease. In order to correctly diagnose anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, cerebrospinal fluid (CSF) examinations including detection of oligoclonal bands, brain MRI scanning, and routine EEG and/or 24 hours video EEG should be performed in children. For highly suspected cases, particularly children presenting with psychiatric symptoms and epileptic seizures, examinations should be done to detect anti-NMDAR antibodies (Abs) in serum and CSF. A notable feature in children is the EEG pattern named "extreme delta brush", which may help confirm the clinical diagnosis. Anti-NMDAR Abs in CSF is the diagnostic "gold-standard" for this disease. The differential diagnosis of anti-NMDAR encephalitis is broad. In pediatric patients, the differential diagnosis should be made mainly with herpes simplex virus encephalitis, other autoimmune encephalitis, and psychosis.

Authors+Show Affiliations

Division of Pediatric Neurology, Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China. wangh1@sj-hospital.org.

Pub Type(s)

English Abstract
Journal Article
Review

Language

chi

PubMed ID

24927431

Citation

Wang, Hua. "[Diagnosis and Differential Diagnosis of anti-N-methyl-D-aspartate Receptor Encephalitis in Children]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 16, no. 6, 2014, pp. 578-83.
Wang H. [Diagnosis and differential diagnosis of anti-N-methyl-D-aspartate receptor encephalitis in children]. Zhongguo Dang Dai Er Ke Za Zhi. 2014;16(6):578-83.
Wang, H. (2014). [Diagnosis and differential diagnosis of anti-N-methyl-D-aspartate receptor encephalitis in children]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 16(6), 578-83.
Wang H. [Diagnosis and Differential Diagnosis of anti-N-methyl-D-aspartate Receptor Encephalitis in Children]. Zhongguo Dang Dai Er Ke Za Zhi. 2014;16(6):578-83. PubMed PMID: 24927431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnosis and differential diagnosis of anti-N-methyl-D-aspartate receptor encephalitis in children]. A1 - Wang,Hua, PY - 2014/6/14/entrez PY - 2014/6/14/pubmed PY - 2014/10/17/medline SP - 578 EP - 83 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 16 IS - 6 N2 - Autoimmune encephalitis is rare and has various clinical manifestations, which may hamper the correct diagnosis. Therefore, the pediatrician should be familiar with the clinical symptoms, signs, laboratory features, neuroimaging changes, immunological characteristics, and differential diagnosis of this disease. In order to correctly diagnose anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, cerebrospinal fluid (CSF) examinations including detection of oligoclonal bands, brain MRI scanning, and routine EEG and/or 24 hours video EEG should be performed in children. For highly suspected cases, particularly children presenting with psychiatric symptoms and epileptic seizures, examinations should be done to detect anti-NMDAR antibodies (Abs) in serum and CSF. A notable feature in children is the EEG pattern named "extreme delta brush", which may help confirm the clinical diagnosis. Anti-NMDAR Abs in CSF is the diagnostic "gold-standard" for this disease. The differential diagnosis of anti-NMDAR encephalitis is broad. In pediatric patients, the differential diagnosis should be made mainly with herpes simplex virus encephalitis, other autoimmune encephalitis, and psychosis. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/24927431/[Diagnosis_and_differential_diagnosis_of_anti_N_methyl_D_aspartate_receptor_encephalitis_in_children]_ L2 - http://www.zgddek.com/EN/abstract/abstract13395.shtml DB - PRIME DP - Unbound Medicine ER -