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Added benefit of nucleic acid amplification testing for the diagnosis of Trichomonas vaginalis among men and women attending a sexually transmitted diseases clinic.
Clin Infect Dis. 2014 Sep 15; 59(6):834-41.CI

Abstract

BACKGROUND

Trichomonas vaginalis (TV) is the most common nonviral sexually transmitted infection (STI) in the world. However, TV is not a reportable STI and, with the exception of HIV-positive women, there are no guidelines for screening in women or men. The objective of this study was to determine the added value of nucleic acid amplification tests (NAATs) for detection of TV in men and women at high risk for infection as well as correlates of infection.

METHODS

This was a review of clinical and laboratory data of men and women presenting to the Jefferson County Department of Health Sexually Transmitted Diseases (STD) Clinic and receiving a TV NAAT.

RESULTS

During 2012-2013, 6335 patients (3821 women and 2514 men) received a TV NAAT on endocervical, urethral, or urine specimens. Overall TV prevalence was 20.2%; 27.0% in women and 9.8% in men. Correlates of TV among men included age >40 years, African American race, and ≥5 polymorphonuclear cells per high-power field on urethral Gram stain. Age >40 years, African American race, leukorrhea on wet mount, elevated vaginal pH, positive whiff test, and concurrent gonococcal infection were positively associated with TV among women. TV NAAT detected approximately one-third more infections among women than wet mount alone.

CONCLUSIONS

TV prevalence among men and women was high in this study, suggesting that both groups should be routinely screened, including those aged >40 years. Improved detection of TV by routine implementation of NAATs should result in better control of this common, treatable STI.

Authors+Show Affiliations

Division of Infectious Diseases.Department of Medicine, University of Alabama at Birmingham.Quality, Improvement, and Decision Support, Jefferson County Department of Health, Birmingham, Alabama.Division of Infectious Diseases.Division of Infectious Diseases.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24928292

Citation

Muzny, Christina A., et al. "Added Benefit of Nucleic Acid Amplification Testing for the Diagnosis of Trichomonas Vaginalis Among Men and Women Attending a Sexually Transmitted Diseases Clinic." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 59, no. 6, 2014, pp. 834-41.
Muzny CA, Blackburn RJ, Sinsky RJ, et al. Added benefit of nucleic acid amplification testing for the diagnosis of Trichomonas vaginalis among men and women attending a sexually transmitted diseases clinic. Clin Infect Dis. 2014;59(6):834-41.
Muzny, C. A., Blackburn, R. J., Sinsky, R. J., Austin, E. L., & Schwebke, J. R. (2014). Added benefit of nucleic acid amplification testing for the diagnosis of Trichomonas vaginalis among men and women attending a sexually transmitted diseases clinic. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 59(6), 834-41. https://doi.org/10.1093/cid/ciu446
Muzny CA, et al. Added Benefit of Nucleic Acid Amplification Testing for the Diagnosis of Trichomonas Vaginalis Among Men and Women Attending a Sexually Transmitted Diseases Clinic. Clin Infect Dis. 2014 Sep 15;59(6):834-41. PubMed PMID: 24928292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Added benefit of nucleic acid amplification testing for the diagnosis of Trichomonas vaginalis among men and women attending a sexually transmitted diseases clinic. AU - Muzny,Christina A, AU - Blackburn,Reaford J, AU - Sinsky,Richard J, AU - Austin,Erika L, AU - Schwebke,Jane R, Y1 - 2014/06/13/ PY - 2014/6/15/entrez PY - 2014/6/15/pubmed PY - 2015/5/12/medline KW - Trichomonas vaginalis KW - infectiousness KW - nucleic acid amplification test KW - sexually transmitted infection KW - wet mount SP - 834 EP - 41 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 59 IS - 6 N2 - BACKGROUND: Trichomonas vaginalis (TV) is the most common nonviral sexually transmitted infection (STI) in the world. However, TV is not a reportable STI and, with the exception of HIV-positive women, there are no guidelines for screening in women or men. The objective of this study was to determine the added value of nucleic acid amplification tests (NAATs) for detection of TV in men and women at high risk for infection as well as correlates of infection. METHODS: This was a review of clinical and laboratory data of men and women presenting to the Jefferson County Department of Health Sexually Transmitted Diseases (STD) Clinic and receiving a TV NAAT. RESULTS: During 2012-2013, 6335 patients (3821 women and 2514 men) received a TV NAAT on endocervical, urethral, or urine specimens. Overall TV prevalence was 20.2%; 27.0% in women and 9.8% in men. Correlates of TV among men included age >40 years, African American race, and ≥5 polymorphonuclear cells per high-power field on urethral Gram stain. Age >40 years, African American race, leukorrhea on wet mount, elevated vaginal pH, positive whiff test, and concurrent gonococcal infection were positively associated with TV among women. TV NAAT detected approximately one-third more infections among women than wet mount alone. CONCLUSIONS: TV prevalence among men and women was high in this study, suggesting that both groups should be routinely screened, including those aged >40 years. Improved detection of TV by routine implementation of NAATs should result in better control of this common, treatable STI. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/24928292/Added_benefit_of_nucleic_acid_amplification_testing_for_the_diagnosis_of_Trichomonas_vaginalis_among_men_and_women_attending_a_sexually_transmitted_diseases_clinic_ DB - PRIME DP - Unbound Medicine ER -