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Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood.
Pulm Pharmacol Ther 2014; 29(1):31-40PP

Abstract

Asthma is characterized by repeated episodes of airway obstruction and an ongoing cycle of airway inflammation. Reactive oxygen species (ROS) produced by inflammatory cells in the lung play a key role in the pathogenesis as well as amplification of inflammation in asthmatic airways. Several enzymatic and non-enzymatic antioxidants are available in the lung and systemic circulation to counteract ROS-mediated damage on various biomolecules such as lipid membranes, proteins, and DNA; however during asthmatic inflammation these defenses are overwhelmed due to excessive production of ROS thereby leading to inflammatory events in the airways/systemic circulation. ROS-mediated damage may result in increased vascular permeability, mucus hypersecretion, smooth muscle contraction, epithelial shedding and impairment in the responsiveness of β-adrenergic receptors. Strategies aimed to boost the endogenous antioxidants either through dietary or pharmacological intervention to redress oxidant-antioxidant imbalance in asthma is the current area of research in many laboratories throughout the world. This review aims at providing a comprehensive overview of the available literature on oxidative stress and antioxidants imbalance in asthma with a focus both on lung and blood components and bring forth correlations between lung/blood oxidative stress/antioxidant parameters and lung function.

Authors+Show Affiliations

Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: anadeem@ksu.edu.sa.Amity Institute of Biotechnology, Amity University, Noida, India.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24929073

Citation

Nadeem, A, et al. "Airway and Systemic Oxidant-antioxidant Dysregulation in Asthma: a Possible Scenario of Oxidants Spill Over From Lung Into Blood." Pulmonary Pharmacology & Therapeutics, vol. 29, no. 1, 2014, pp. 31-40.
Nadeem A, Siddiqui N, Alharbi NO, et al. Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood. Pulm Pharmacol Ther. 2014;29(1):31-40.
Nadeem, A., Siddiqui, N., Alharbi, N. O., & Alharbi, M. M. (2014). Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood. Pulmonary Pharmacology & Therapeutics, 29(1), pp. 31-40. doi:10.1016/j.pupt.2014.06.001.
Nadeem A, et al. Airway and Systemic Oxidant-antioxidant Dysregulation in Asthma: a Possible Scenario of Oxidants Spill Over From Lung Into Blood. Pulm Pharmacol Ther. 2014;29(1):31-40. PubMed PMID: 24929073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood. AU - Nadeem,A, AU - Siddiqui,N, AU - Alharbi,Naif O, AU - Alharbi,Mohamed M, Y1 - 2014/06/12/ PY - 2014/01/19/received PY - 2014/04/10/revised PY - 2014/06/02/accepted PY - 2014/6/15/entrez PY - 2014/6/15/pubmed PY - 2016/5/5/medline KW - Antioxidant KW - Asthma KW - Blood KW - Inflammation KW - Lung KW - Oxidative stress SP - 31 EP - 40 JF - Pulmonary pharmacology & therapeutics JO - Pulm Pharmacol Ther VL - 29 IS - 1 N2 - Asthma is characterized by repeated episodes of airway obstruction and an ongoing cycle of airway inflammation. Reactive oxygen species (ROS) produced by inflammatory cells in the lung play a key role in the pathogenesis as well as amplification of inflammation in asthmatic airways. Several enzymatic and non-enzymatic antioxidants are available in the lung and systemic circulation to counteract ROS-mediated damage on various biomolecules such as lipid membranes, proteins, and DNA; however during asthmatic inflammation these defenses are overwhelmed due to excessive production of ROS thereby leading to inflammatory events in the airways/systemic circulation. ROS-mediated damage may result in increased vascular permeability, mucus hypersecretion, smooth muscle contraction, epithelial shedding and impairment in the responsiveness of β-adrenergic receptors. Strategies aimed to boost the endogenous antioxidants either through dietary or pharmacological intervention to redress oxidant-antioxidant imbalance in asthma is the current area of research in many laboratories throughout the world. This review aims at providing a comprehensive overview of the available literature on oxidative stress and antioxidants imbalance in asthma with a focus both on lung and blood components and bring forth correlations between lung/blood oxidative stress/antioxidant parameters and lung function. SN - 1522-9629 UR - https://www.unboundmedicine.com/medline/citation/24929073/Airway_and_systemic_oxidant_antioxidant_dysregulation_in_asthma:_a_possible_scenario_of_oxidants_spill_over_from_lung_into_blood_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1094-5539(14)00067-4 DB - PRIME DP - Unbound Medicine ER -