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Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice.
Neuropharmacology 2014; 86:57-66N

Abstract

This study investigated whether the spinal or systemic treatment with the lipid resolution mediators resolvin D1 (RvD1), aspirin-triggered resolvin D1 (AT-RvD1) and resolvin D2 (RvD2) might interfere with behavioral and neurochemical changes in the mouse fibromyalgia-like model induced by reserpine. Acute administration of AT-RvD1 and RvD2 produced a significant inhibition of mechanical allodynia and thermal sensitization in reserpine-treated mice, whereas RvD1 was devoid of effects. A similar antinociceptive effect was obtained by acutely treating animals with the reference drug pregabalin. Noteworthy, the repeated administration of AT-RvD1 and RvD2 also prevented the depressive-like behavior in reserpine-treated animals, according to assessment of immobility time, although the chronic administration of pregabalin failed to affect this parameter. The induction of fibromyalgia by reserpine triggered a marked decrease of dopamine and serotonin (5-HT) levels, as examined in total brain, spinal cord, cortex and thalamus. Reserpine also elicited a reduction of glutamate levels in total brain, and a significant increase in the spinal cord and thalamus. Chronic treatment with RvD2 prevented 5-HT reduction in total brain, and reversed the glutamate increases in total brain and spinal cord. Otherwise, AT-RvD1 led to a recovery of dopamine levels in cortex, and 5-HT in thalamus, whilst it diminished brain glutamate contents. Concerning pregabalin, this drug prevented dopamine reduction in total brain, and inhibited glutamate increase in brain and spinal cord of reserpine-treated animals. Our data provide novel evidence, showing the ability of D-series resolvins AT-RvD1, and mainly RvD2, in reducing painful and depressive symptoms allied to fibromyalgia in mice.

Authors+Show Affiliations

Postgraduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.Faculty of Pharmacy, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.Postgraduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.Institute of Toxicology and Pharmacology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.Institute of Toxicology and Pharmacology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.Postgraduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Postgraduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Institute of Toxicology and Pharmacology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil; School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: camposmmartha@yahoo.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24929111

Citation

Klein, Caroline P., et al. "Effects of D-series Resolvins On Behavioral and Neurochemical Changes in a Fibromyalgia-like Model in Mice." Neuropharmacology, vol. 86, 2014, pp. 57-66.
Klein CP, Sperotto ND, Maciel IS, et al. Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. Neuropharmacology. 2014;86:57-66.
Klein, C. P., Sperotto, N. D., Maciel, I. S., Leite, C. E., Souza, A. H., & Campos, M. M. (2014). Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. Neuropharmacology, 86, pp. 57-66. doi:10.1016/j.neuropharm.2014.05.043.
Klein CP, et al. Effects of D-series Resolvins On Behavioral and Neurochemical Changes in a Fibromyalgia-like Model in Mice. Neuropharmacology. 2014;86:57-66. PubMed PMID: 24929111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. AU - Klein,Caroline P, AU - Sperotto,Nathalia D M, AU - Maciel,Izaque S, AU - Leite,Carlos E, AU - Souza,Alessandra H, AU - Campos,Maria M, Y1 - 2014/06/11/ PY - 2014/03/07/received PY - 2014/05/27/revised PY - 2014/05/29/accepted PY - 2014/6/15/entrez PY - 2014/6/15/pubmed PY - 2015/7/15/medline KW - D-series resolvins KW - Fibromyalgia KW - Mice KW - Neurotransmitters KW - Pregabalin KW - Reserpine SP - 57 EP - 66 JF - Neuropharmacology JO - Neuropharmacology VL - 86 N2 - This study investigated whether the spinal or systemic treatment with the lipid resolution mediators resolvin D1 (RvD1), aspirin-triggered resolvin D1 (AT-RvD1) and resolvin D2 (RvD2) might interfere with behavioral and neurochemical changes in the mouse fibromyalgia-like model induced by reserpine. Acute administration of AT-RvD1 and RvD2 produced a significant inhibition of mechanical allodynia and thermal sensitization in reserpine-treated mice, whereas RvD1 was devoid of effects. A similar antinociceptive effect was obtained by acutely treating animals with the reference drug pregabalin. Noteworthy, the repeated administration of AT-RvD1 and RvD2 also prevented the depressive-like behavior in reserpine-treated animals, according to assessment of immobility time, although the chronic administration of pregabalin failed to affect this parameter. The induction of fibromyalgia by reserpine triggered a marked decrease of dopamine and serotonin (5-HT) levels, as examined in total brain, spinal cord, cortex and thalamus. Reserpine also elicited a reduction of glutamate levels in total brain, and a significant increase in the spinal cord and thalamus. Chronic treatment with RvD2 prevented 5-HT reduction in total brain, and reversed the glutamate increases in total brain and spinal cord. Otherwise, AT-RvD1 led to a recovery of dopamine levels in cortex, and 5-HT in thalamus, whilst it diminished brain glutamate contents. Concerning pregabalin, this drug prevented dopamine reduction in total brain, and inhibited glutamate increase in brain and spinal cord of reserpine-treated animals. Our data provide novel evidence, showing the ability of D-series resolvins AT-RvD1, and mainly RvD2, in reducing painful and depressive symptoms allied to fibromyalgia in mice. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/24929111/Effects_of_D_series_resolvins_on_behavioral_and_neurochemical_changes_in_a_fibromyalgia_like_model_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(14)00219-6 DB - PRIME DP - Unbound Medicine ER -