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Association between dietary fiber intake and risk of coronary heart disease: A meta-analysis.

Abstract

BACKGROUND & AIMS

The association between coronary heart disease (CHD) and dietary fiber intake is not consistent, especially for the subtypes of dietary fiber. The aim of our study was to conduct a meta-analysis of existing cohort published studies assessing the association between dietary fiber intake and risk of CHD, and quantitatively estimating their dose-response relationships.

METHODS

We searched PubMed and EMBASE before May 2013. Random-effect model was used to calculate the pool relative risk (RRs) for the incidence and mortality of CHD. Dose-response, subgroup analyses based on fiber subtypes, heterogeneity and publication bias were also carried out.

RESULTS

Eighteen studies involving 672,408 individuals were finally included in the present study. The pooled-adjusted RRs of coronary heart disease for the highest versus lowest category of fiber intake were 0.93 (95% confidence interval (CI), 0.91-0.96, P < 0.001) for incidence of all coronary events and 0.83 (95% CI, 0.76-0.91, P < 0.001) for mortality. Further subgroup analyses based on fiber subtypes (cereal, fruit, and vegetable fiber), indicated that RRs were 0.92 (95% CI, 0.85-0.99, P = 0.032), 0.92 (95% CI, 0.86-0.98, P = 0.01), 0.95 (95% CI, 0.89-1.01, P = 0.098) respectively for all coronary event and 0.81 (95% CI, 0.72-0.92, P = 0.001), 0.68 (95% CI, 0.43-1.07, P = 0.094), 0.91 (95% CI, 0.74-1.12, P = 0.383) for mortality. In addition, a significant dose-response relationship was observed between fiber intake and the incidence and mortality of CHD (P < 0.001).

CONCLUSIONS

Our results indicate that consumption of dietary fiber is inversely associated with risk of coronary heart disease, especially for fiber from cereals and fruits. Besides, soluble and insoluble fibers have the similar effect. A significant dose-response relationship is also observed between fiber intake and CHD risk.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, 310058, China.

    ,

    Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.

    ,

    Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.

    ,

    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, 310058, China.

    ,

    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, 310058, China.

    ,

    Department of Cardiology, The First People's Hospital of Hangzhou, Hangzhou, 310000, China. Electronic address: doctoryexianhua@126.com.

    Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. Electronic address: Xugeng@21cn.com.

    Source

    MeSH

    Coronary Artery Disease
    Databases, Factual
    Dietary Fiber
    Edible Grain
    Fruit
    Humans
    Incidence
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24929874

    Citation

    Wu, Yihua, et al. "Association Between Dietary Fiber Intake and Risk of Coronary Heart Disease: a Meta-analysis." Clinical Nutrition (Edinburgh, Scotland), vol. 34, no. 4, 2015, pp. 603-11.
    Wu Y, Qian Y, Pan Y, et al. Association between dietary fiber intake and risk of coronary heart disease: A meta-analysis. Clin Nutr. 2015;34(4):603-11.
    Wu, Y., Qian, Y., Pan, Y., Li, P., Yang, J., Ye, X., & Xu, G. (2015). Association between dietary fiber intake and risk of coronary heart disease: A meta-analysis. Clinical Nutrition (Edinburgh, Scotland), 34(4), pp. 603-11. doi:10.1016/j.clnu.2014.05.009.
    Wu Y, et al. Association Between Dietary Fiber Intake and Risk of Coronary Heart Disease: a Meta-analysis. Clin Nutr. 2015;34(4):603-11. PubMed PMID: 24929874.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between dietary fiber intake and risk of coronary heart disease: A meta-analysis. AU - Wu,Yihua, AU - Qian,Yufeng, AU - Pan,Yiwen, AU - Li,Peiwei, AU - Yang,Jun, AU - Ye,Xianhua, AU - Xu,Geng, Y1 - 2014/05/28/ PY - 2014/03/02/received PY - 2014/05/12/revised PY - 2014/05/19/accepted PY - 2014/6/16/entrez PY - 2014/6/16/pubmed PY - 2016/3/26/medline KW - Coronary disease KW - Dietary fiber KW - Incidence KW - Meta-analysis KW - Mortality SP - 603 EP - 11 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 34 IS - 4 N2 - BACKGROUND & AIMS: The association between coronary heart disease (CHD) and dietary fiber intake is not consistent, especially for the subtypes of dietary fiber. The aim of our study was to conduct a meta-analysis of existing cohort published studies assessing the association between dietary fiber intake and risk of CHD, and quantitatively estimating their dose-response relationships. METHODS: We searched PubMed and EMBASE before May 2013. Random-effect model was used to calculate the pool relative risk (RRs) for the incidence and mortality of CHD. Dose-response, subgroup analyses based on fiber subtypes, heterogeneity and publication bias were also carried out. RESULTS: Eighteen studies involving 672,408 individuals were finally included in the present study. The pooled-adjusted RRs of coronary heart disease for the highest versus lowest category of fiber intake were 0.93 (95% confidence interval (CI), 0.91-0.96, P < 0.001) for incidence of all coronary events and 0.83 (95% CI, 0.76-0.91, P < 0.001) for mortality. Further subgroup analyses based on fiber subtypes (cereal, fruit, and vegetable fiber), indicated that RRs were 0.92 (95% CI, 0.85-0.99, P = 0.032), 0.92 (95% CI, 0.86-0.98, P = 0.01), 0.95 (95% CI, 0.89-1.01, P = 0.098) respectively for all coronary event and 0.81 (95% CI, 0.72-0.92, P = 0.001), 0.68 (95% CI, 0.43-1.07, P = 0.094), 0.91 (95% CI, 0.74-1.12, P = 0.383) for mortality. In addition, a significant dose-response relationship was observed between fiber intake and the incidence and mortality of CHD (P < 0.001). CONCLUSIONS: Our results indicate that consumption of dietary fiber is inversely associated with risk of coronary heart disease, especially for fiber from cereals and fruits. Besides, soluble and insoluble fibers have the similar effect. A significant dose-response relationship is also observed between fiber intake and CHD risk. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/24929874/Association_between_dietary_fiber_intake_and_risk_of_coronary_heart_disease:_A_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(14)00140-X DB - PRIME DP - Unbound Medicine ER -