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High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma - 5-year follow up of a population-based study.
Acta Otolaryngol. 2014 Aug; 134(8):843-51.AO

Abstract

CONCLUSION

No statistically significant 5-year survival difference was seen in patients with oral and oropharyngeal squamous cell carcinoma (OOPSCC) between high-risk HPV-positive and -negative groups in this population-based study.

OBJECTIVES

To see if the formerly observed higher risk for recurrence or second primary tumour (SPT) in high-risk HPV-positive patients with OOPSCC corresponds to worse survival.

METHODS

A total of 128 consecutive, previously untreated patients with OOPSCC, who were part of a population-based case-control study in southern Sweden during 2000-2004, were included. A mouthwash sample was collected and exfoliated cells were collected with cotton-tipped swabs from the tonsillar fossa and the tumour. Specimens were analysed for HPV DNA using nested polymerase chain reaction (PCR). Disease-specific survival (DSS) and DSS difference between HPV-negative and HPV-positive patients were calculated. The relationship between age, stage, high-risk HPV status and DSS was assessed. Oral and oropharyngeal tumours were assessed separately.

RESULTS

Mean DSS in months was 80.7/68.6 (high-risk HPV-negative/high-risk HPV-positive) for oral cavity tumours (p = 0.18) and 67.6/78.3 (high-risk HPV-negative/high-risk HPV-positive) for oropharyngeal tumours (p = 0.47). For oral cavity tumours, age, T status, N status and stage all showed significant differences in DSS. For oropharyngeal tumours, no significant difference regarding DSS was found.

Authors+Show Affiliations

Division of Otorhinolaryngology/Head & Neck Surgery, Department of Clinical Sciences, Lund University , Lund.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24930912

Citation

Annertz, Karin, et al. "High-risk HPV and Survival in Patients With Oral and Oropharyngeal Squamous Cell Carcinoma - 5-year Follow Up of a Population-based Study." Acta Oto-laryngologica, vol. 134, no. 8, 2014, pp. 843-51.
Annertz K, Rosenquist K, Andersson G, et al. High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma - 5-year follow up of a population-based study. Acta Otolaryngol. 2014;134(8):843-51.
Annertz, K., Rosenquist, K., Andersson, G., Jacobsson, H., Hansson, B. G., & Wennerberg, J. (2014). High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma - 5-year follow up of a population-based study. Acta Oto-laryngologica, 134(8), 843-51. https://doi.org/10.3109/00016489.2014.890289
Annertz K, et al. High-risk HPV and Survival in Patients With Oral and Oropharyngeal Squamous Cell Carcinoma - 5-year Follow Up of a Population-based Study. Acta Otolaryngol. 2014;134(8):843-51. PubMed PMID: 24930912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma - 5-year follow up of a population-based study. AU - Annertz,Karin, AU - Rosenquist,Kerstin, AU - Andersson,Gunilla, AU - Jacobsson,Helene, AU - Hansson,Bengt Göran, AU - Wennerberg,Johan, Y1 - 2014/06/16/ PY - 2014/6/17/entrez PY - 2014/6/17/pubmed PY - 2015/4/1/medline KW - Oral cancer KW - oropharyngeal cancer KW - prognosis KW - survival SP - 843 EP - 51 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 134 IS - 8 N2 - CONCLUSION: No statistically significant 5-year survival difference was seen in patients with oral and oropharyngeal squamous cell carcinoma (OOPSCC) between high-risk HPV-positive and -negative groups in this population-based study. OBJECTIVES: To see if the formerly observed higher risk for recurrence or second primary tumour (SPT) in high-risk HPV-positive patients with OOPSCC corresponds to worse survival. METHODS: A total of 128 consecutive, previously untreated patients with OOPSCC, who were part of a population-based case-control study in southern Sweden during 2000-2004, were included. A mouthwash sample was collected and exfoliated cells were collected with cotton-tipped swabs from the tonsillar fossa and the tumour. Specimens were analysed for HPV DNA using nested polymerase chain reaction (PCR). Disease-specific survival (DSS) and DSS difference between HPV-negative and HPV-positive patients were calculated. The relationship between age, stage, high-risk HPV status and DSS was assessed. Oral and oropharyngeal tumours were assessed separately. RESULTS: Mean DSS in months was 80.7/68.6 (high-risk HPV-negative/high-risk HPV-positive) for oral cavity tumours (p = 0.18) and 67.6/78.3 (high-risk HPV-negative/high-risk HPV-positive) for oropharyngeal tumours (p = 0.47). For oral cavity tumours, age, T status, N status and stage all showed significant differences in DSS. For oropharyngeal tumours, no significant difference regarding DSS was found. SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/24930912/High_risk_HPV_and_survival_in_patients_with_oral_and_oropharyngeal_squamous_cell_carcinoma___5_year_follow_up_of_a_population_based_study_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016489.2014.890289 DB - PRIME DP - Unbound Medicine ER -