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Multiple endocrine neoplasia (MEN) syndromes.
Semin Pediatr Surg. 2014 Apr; 23(2):96-101.SP

Abstract

Multiple endocrine neoplasia (MEN) syndromes are characterised by the combined occurrence of two or more endocrine tumours in a patient. These autosomal dominant conditions occur in four types: MEN1 due to inactivating MEN1 mutations; MEN2A and MEN2B (MEN3) due to activating mutations of RET and MEN4 due to inactivating cyclin-dependent kinase inhibitor 1B (CDKN1B) mutations. Each MEN syndrome exhibits different combinations of pancreatic islet, anterior pituitary, parathyroid, medullary thyroid and adrenal tumours. This article provides an overview of the clinical features, treatments and molecular genetics of each endocrine tumour syndrome.

Authors+Show Affiliations

Nuffield Department of Surgical Sciences, University of Oxford, Headington, Oxford, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Headington, Oxford, UK. Electronic address: gerard.walls@nds.ox.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24931355

Citation

Walls, Gerard V.. "Multiple Endocrine Neoplasia (MEN) Syndromes." Seminars in Pediatric Surgery, vol. 23, no. 2, 2014, pp. 96-101.
Walls GV. Multiple endocrine neoplasia (MEN) syndromes. Semin Pediatr Surg. 2014;23(2):96-101.
Walls, G. V. (2014). Multiple endocrine neoplasia (MEN) syndromes. Seminars in Pediatric Surgery, 23(2), 96-101. https://doi.org/10.1053/j.sempedsurg.2014.03.008
Walls GV. Multiple Endocrine Neoplasia (MEN) Syndromes. Semin Pediatr Surg. 2014;23(2):96-101. PubMed PMID: 24931355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple endocrine neoplasia (MEN) syndromes. A1 - Walls,Gerard V, Y1 - 2014/03/15/ PY - 2014/6/17/entrez PY - 2014/6/17/pubmed PY - 2015/1/30/medline KW - Adrenal KW - Endocrine Tumours KW - Pancreatic KW - Parathyroid KW - Pituitary KW - Thyroid SP - 96 EP - 101 JF - Seminars in pediatric surgery JO - Semin Pediatr Surg VL - 23 IS - 2 N2 - Multiple endocrine neoplasia (MEN) syndromes are characterised by the combined occurrence of two or more endocrine tumours in a patient. These autosomal dominant conditions occur in four types: MEN1 due to inactivating MEN1 mutations; MEN2A and MEN2B (MEN3) due to activating mutations of RET and MEN4 due to inactivating cyclin-dependent kinase inhibitor 1B (CDKN1B) mutations. Each MEN syndrome exhibits different combinations of pancreatic islet, anterior pituitary, parathyroid, medullary thyroid and adrenal tumours. This article provides an overview of the clinical features, treatments and molecular genetics of each endocrine tumour syndrome. SN - 1532-9453 UR - https://www.unboundmedicine.com/medline/citation/24931355/Multiple_endocrine_neoplasia__MEN__syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1055-8586(14)00010-9 DB - PRIME DP - Unbound Medicine ER -