Tags

Type your tag names separated by a space and hit enter

Dynamic analysis of oral Candida carriage, distribution, and antifungal susceptibility in HIV-infected patients during the first year of highly active antiretroviral therapy in Guangxi, China.
J Oral Pathol Med. 2014 Oct; 43(9):696-703.JO

Abstract

BACKGROUND

Highly active antiretroviral therapy (HAART) as an effective therapy for immune reconstruction among patients with HIV/AIDS might have influence on oral Candida status. We investigated oral Candida carriage, distribution, and antifungal susceptibility dynamically during the first year of HAART among adult HIV-infected patients in Guangxi, China.

METHODS

Forty-five adult HIV-infected patients who received their first year HAART in the AIDS clinic of the Guangxi Center for Disease Control (CDC) and 31 healthy individuals were recruited. Clinical information and oral examinations were obtained. Oral rinses taken from patients at baseline, 3, 6, 12 months during HAART, respectively, were cultured, and Candida species were identified following standard microbiological techniques. In vitro antifungal susceptibilities were tested by the broth microdilution method.

RESULTS

The oral Candida load decreased gradually in the 45 patients with HIV/AIDS during the first year of HAART (P < 0.050). Among 176 Candida isolates, Candida albicans (114/176) was the predominant species, and Candida parapsilosis (23/62) was the most common non-albicans species. We found the frequency of resistance to fluconazole and itraconazole of Candida isolated from our samples increased (P < 0.05) after 12 months of HAART. In addition, the frequency of C. albicans isolates resistant to fluconazole and itraconazole was on the rise (P < 0.05).

CONCLUSIONS

The Candida load decreased with increased CD4(+) T cell counts, and C. albicans was still the prevailing species. Further, a trend toward more frequent in vitro resistance to fluconazole and itraconazole was observed. Our results provide reference for treatment and prevention of oral candidiasis among this population.

Authors+Show Affiliations

Department of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Guangxi, China; Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Guangxi, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24931443

Citation

Jiang, Lanlan, et al. "Dynamic Analysis of Oral Candida Carriage, Distribution, and Antifungal Susceptibility in HIV-infected Patients During the First Year of Highly Active Antiretroviral Therapy in Guangxi, China." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 43, no. 9, 2014, pp. 696-703.
Jiang L, Yong X, Li R, et al. Dynamic analysis of oral Candida carriage, distribution, and antifungal susceptibility in HIV-infected patients during the first year of highly active antiretroviral therapy in Guangxi, China. J Oral Pathol Med. 2014;43(9):696-703.
Jiang, L., Yong, X., Li, R., Peng, Y., Liu, W., Qin, Q., Zhang, L., Liu, Z., Liang, H., & Tao, R. (2014). Dynamic analysis of oral Candida carriage, distribution, and antifungal susceptibility in HIV-infected patients during the first year of highly active antiretroviral therapy in Guangxi, China. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(9), 696-703. https://doi.org/10.1111/jop.12192
Jiang L, et al. Dynamic Analysis of Oral Candida Carriage, Distribution, and Antifungal Susceptibility in HIV-infected Patients During the First Year of Highly Active Antiretroviral Therapy in Guangxi, China. J Oral Pathol Med. 2014;43(9):696-703. PubMed PMID: 24931443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamic analysis of oral Candida carriage, distribution, and antifungal susceptibility in HIV-infected patients during the first year of highly active antiretroviral therapy in Guangxi, China. AU - Jiang,Lanlan, AU - Yong,Xiangzhi, AU - Li,Runying, AU - Peng,Yuanyuan, AU - Liu,Wei, AU - Qin,Qi, AU - Zhang,Linlin, AU - Liu,Zhenmin, AU - Liang,Hao, AU - Tao,Renchuan, Y1 - 2014/06/14/ PY - 2014/03/06/accepted PY - 2014/6/17/entrez PY - 2014/6/17/pubmed PY - 2015/8/21/medline KW - China KW - HAART KW - HIV/AIDS KW - antifungal susceptibility KW - oral Candida SP - 696 EP - 703 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J. Oral Pathol. Med. VL - 43 IS - 9 N2 - BACKGROUND: Highly active antiretroviral therapy (HAART) as an effective therapy for immune reconstruction among patients with HIV/AIDS might have influence on oral Candida status. We investigated oral Candida carriage, distribution, and antifungal susceptibility dynamically during the first year of HAART among adult HIV-infected patients in Guangxi, China. METHODS: Forty-five adult HIV-infected patients who received their first year HAART in the AIDS clinic of the Guangxi Center for Disease Control (CDC) and 31 healthy individuals were recruited. Clinical information and oral examinations were obtained. Oral rinses taken from patients at baseline, 3, 6, 12 months during HAART, respectively, were cultured, and Candida species were identified following standard microbiological techniques. In vitro antifungal susceptibilities were tested by the broth microdilution method. RESULTS: The oral Candida load decreased gradually in the 45 patients with HIV/AIDS during the first year of HAART (P < 0.050). Among 176 Candida isolates, Candida albicans (114/176) was the predominant species, and Candida parapsilosis (23/62) was the most common non-albicans species. We found the frequency of resistance to fluconazole and itraconazole of Candida isolated from our samples increased (P < 0.05) after 12 months of HAART. In addition, the frequency of C. albicans isolates resistant to fluconazole and itraconazole was on the rise (P < 0.05). CONCLUSIONS: The Candida load decreased with increased CD4(+) T cell counts, and C. albicans was still the prevailing species. Further, a trend toward more frequent in vitro resistance to fluconazole and itraconazole was observed. Our results provide reference for treatment and prevention of oral candidiasis among this population. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/24931443/Dynamic_analysis_of_oral_Candida_carriage_distribution_and_antifungal_susceptibility_in_HIV_infected_patients_during_the_first_year_of_highly_active_antiretroviral_therapy_in_Guangxi_China_ DB - PRIME DP - Unbound Medicine ER -