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Parenteral immunonutrition in patients with acute pancreatitis: a systematic review and meta-analysis.
Clin Nutr. 2015 Feb; 34(1):35-43.CN

Abstract

BACKGROUND & AIMS

Acute pancreatitis is a systemic immunoinflammatory response to auto-digestion of the pancrease and peri-pancreatic organs. Patients with acute pancreatitis can rapidly develop nutritional deficiency; hence nutritional support is important and critical. Sometimes parenteral nutrition (PN) is inevitable in acute pancreatitis. Due to immunosuppressive and inflammatory nature of the disease, it seems that immunonutrients like glutamine and omega-3 fatty acids (ω-3 FAs) added to parenteral formulas may improve the conditions. We conducted a meta-analysis to evaluate the effects of parenteral immunonutrition on clinical outcomes (infectious complications, length of hospital stay (LOS) and mortality) in patients with acute pancreatitis.

METHODS

A computerized literature search on four databases (PubMed, Cochrane, ISI Web of Science, and Iran Medex) was performed to find all the randomized controlled trials (RCTs) assessed the effects of parenteral immunonutrition in acute pancreatitis. Necessary data were extracted and quality assessment of RCTs was performed with consensus in the study team. Fixed effects model was used to conduct the meta-analysis.

RESULTS

One hundred and ninety four references were found via our search in which 7 articles matched our criteria for enrolling the meta-analysis. Parenteral immunonutrition significantly reduced the risk of infectious complications (RR = 0.59; 95% CI, 0.39-0.88; p ≤ 0.05) and mortality (RR = 0.26; 95% CI, 0.11-0.59; p ≤ 0.001). LOS was also shorter in patients who received immunonutrition (MD = -2.93 days; 95% CI, -4.70 to -1.15; p ≤ 0.001).

CONCLUSION

Immunonutrients like glutamine and ω-3 FAs added to parenteral formulas can improve prognoses in patients with acute pancreatitis.

Authors+Show Affiliations

Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: tinajafari15@yahoo.com.Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran; Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord 34141, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

24931755

Citation

Jafari, Tina, et al. "Parenteral Immunonutrition in Patients With Acute Pancreatitis: a Systematic Review and Meta-analysis." Clinical Nutrition (Edinburgh, Scotland), vol. 34, no. 1, 2015, pp. 35-43.
Jafari T, Feizi A, Askari G, et al. Parenteral immunonutrition in patients with acute pancreatitis: a systematic review and meta-analysis. Clin Nutr. 2015;34(1):35-43.
Jafari, T., Feizi, A., Askari, G., & Fallah, A. A. (2015). Parenteral immunonutrition in patients with acute pancreatitis: a systematic review and meta-analysis. Clinical Nutrition (Edinburgh, Scotland), 34(1), 35-43. https://doi.org/10.1016/j.clnu.2014.05.008
Jafari T, et al. Parenteral Immunonutrition in Patients With Acute Pancreatitis: a Systematic Review and Meta-analysis. Clin Nutr. 2015;34(1):35-43. PubMed PMID: 24931755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parenteral immunonutrition in patients with acute pancreatitis: a systematic review and meta-analysis. AU - Jafari,Tina, AU - Feizi,Awat, AU - Askari,Gholamreza, AU - Fallah,Aziz A, Y1 - 2014/05/28/ PY - 2013/08/11/received PY - 2014/04/01/revised PY - 2014/05/15/accepted PY - 2014/6/17/entrez PY - 2014/6/17/pubmed PY - 2015/10/2/medline KW - Acute pancreatitis KW - Glutamine KW - Meta-analysis KW - Omega-3 fatty acids KW - Parenteral immunonutrition KW - Randomized controlled trials SP - 35 EP - 43 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 34 IS - 1 N2 - BACKGROUND & AIMS: Acute pancreatitis is a systemic immunoinflammatory response to auto-digestion of the pancrease and peri-pancreatic organs. Patients with acute pancreatitis can rapidly develop nutritional deficiency; hence nutritional support is important and critical. Sometimes parenteral nutrition (PN) is inevitable in acute pancreatitis. Due to immunosuppressive and inflammatory nature of the disease, it seems that immunonutrients like glutamine and omega-3 fatty acids (ω-3 FAs) added to parenteral formulas may improve the conditions. We conducted a meta-analysis to evaluate the effects of parenteral immunonutrition on clinical outcomes (infectious complications, length of hospital stay (LOS) and mortality) in patients with acute pancreatitis. METHODS: A computerized literature search on four databases (PubMed, Cochrane, ISI Web of Science, and Iran Medex) was performed to find all the randomized controlled trials (RCTs) assessed the effects of parenteral immunonutrition in acute pancreatitis. Necessary data were extracted and quality assessment of RCTs was performed with consensus in the study team. Fixed effects model was used to conduct the meta-analysis. RESULTS: One hundred and ninety four references were found via our search in which 7 articles matched our criteria for enrolling the meta-analysis. Parenteral immunonutrition significantly reduced the risk of infectious complications (RR = 0.59; 95% CI, 0.39-0.88; p ≤ 0.05) and mortality (RR = 0.26; 95% CI, 0.11-0.59; p ≤ 0.001). LOS was also shorter in patients who received immunonutrition (MD = -2.93 days; 95% CI, -4.70 to -1.15; p ≤ 0.001). CONCLUSION: Immunonutrients like glutamine and ω-3 FAs added to parenteral formulas can improve prognoses in patients with acute pancreatitis. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/24931755/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(14)00139-3 DB - PRIME DP - Unbound Medicine ER -