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Predictors of quality of life in 102 patients with treated Cushing's disease.
Clin Endocrinol (Oxf) 2015; 82(3):404-11CE

Abstract

OBJECTIVE

To identify predictors for quality of life (QoL) in treated Cushing's disease (CD) and quantify patients' assessment of their disease status.

CONTEXT

Significant reductions in QoL exist in CD patients despite treatment. Identifying predictors of QoL is paramount to the long-term management of these patents.

DESIGN

A cross-sectional study was conducted of patients with treated CD. Patients completed a medical history questionnaire and three validated quality of life assessments: Cushing's QoL Questionnaire (CushingQoL), Hospital Anxiety and Depression Scale (HADS) and Nottingham Health Profile (NHP).

PATIENTS

102 patients (75·7% female, mean time since surgery 7·4 years) with treated CD were included.

MEASUREMENTS

Patients were categorized by biochemical and self-identified disease status. Mean CushingQoL, anxiety and depression scores were compared by unpaired t-tests. Multiple linear regressions were performed on the whole cohort to assess for predictors of impaired QoL.

RESULTS

Ninety-two per cent of the cohort met criteria for biochemical remission, but only 80·4% felt they had achieved remission. Among those with biochemical remission, those who also self-identified as being in remission had higher CushingQoL scores than those who self-identified as having persistent disease (P = 0·042). Anxiety (P = 0·032) and depression (P = 0·018) scores were lower, and CushingQoL scores were higher (P = 0·05) in patients who self-identified as being in remission compared to persistence. Recovery time, BMI, gender and age were also predictors for QoL.

CONCLUSION

Our study identifies the discordance that can exist between biochemical and self-assessed disease status and demonstrates its impact on QoL in patients with CD. These findings highlight the importance of incorporating patients' disease perceptions in their management.

Authors+Show Affiliations

Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24931777

Citation

Carluccio, Alessia, et al. "Predictors of Quality of Life in 102 Patients With Treated Cushing's Disease." Clinical Endocrinology, vol. 82, no. 3, 2015, pp. 404-11.
Carluccio A, Sundaram NK, Chablani S, et al. Predictors of quality of life in 102 patients with treated Cushing's disease. Clin Endocrinol (Oxf). 2015;82(3):404-11.
Carluccio, A., Sundaram, N. K., Chablani, S., Amrock, L. G., Lambert, J. K., Post, K. D., & Geer, E. B. (2015). Predictors of quality of life in 102 patients with treated Cushing's disease. Clinical Endocrinology, 82(3), pp. 404-11. doi:10.1111/cen.12521.
Carluccio A, et al. Predictors of Quality of Life in 102 Patients With Treated Cushing's Disease. Clin Endocrinol (Oxf). 2015;82(3):404-11. PubMed PMID: 24931777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of quality of life in 102 patients with treated Cushing's disease. AU - Carluccio,Alessia, AU - Sundaram,Nina K, AU - Chablani,Sumedha, AU - Amrock,Levana G, AU - Lambert,Jessica K, AU - Post,Kalmon D, AU - Geer,Eliza B, Y1 - 2014/07/02/ PY - 2014/02/11/received PY - 2014/03/03/revised PY - 2014/05/24/revised PY - 2014/06/03/accepted PY - 2014/6/17/entrez PY - 2014/6/17/pubmed PY - 2015/12/22/medline SP - 404 EP - 11 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 82 IS - 3 N2 - OBJECTIVE: To identify predictors for quality of life (QoL) in treated Cushing's disease (CD) and quantify patients' assessment of their disease status. CONTEXT: Significant reductions in QoL exist in CD patients despite treatment. Identifying predictors of QoL is paramount to the long-term management of these patents. DESIGN: A cross-sectional study was conducted of patients with treated CD. Patients completed a medical history questionnaire and three validated quality of life assessments: Cushing's QoL Questionnaire (CushingQoL), Hospital Anxiety and Depression Scale (HADS) and Nottingham Health Profile (NHP). PATIENTS: 102 patients (75·7% female, mean time since surgery 7·4 years) with treated CD were included. MEASUREMENTS: Patients were categorized by biochemical and self-identified disease status. Mean CushingQoL, anxiety and depression scores were compared by unpaired t-tests. Multiple linear regressions were performed on the whole cohort to assess for predictors of impaired QoL. RESULTS: Ninety-two per cent of the cohort met criteria for biochemical remission, but only 80·4% felt they had achieved remission. Among those with biochemical remission, those who also self-identified as being in remission had higher CushingQoL scores than those who self-identified as having persistent disease (P = 0·042). Anxiety (P = 0·032) and depression (P = 0·018) scores were lower, and CushingQoL scores were higher (P = 0·05) in patients who self-identified as being in remission compared to persistence. Recovery time, BMI, gender and age were also predictors for QoL. CONCLUSION: Our study identifies the discordance that can exist between biochemical and self-assessed disease status and demonstrates its impact on QoL in patients with CD. These findings highlight the importance of incorporating patients' disease perceptions in their management. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/24931777/Predictors_of_quality_of_life_in_102_patients_with_treated_Cushing's_disease_ L2 - https://doi.org/10.1111/cen.12521 DB - PRIME DP - Unbound Medicine ER -