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Lack of association between peripheral activity of thyroid hormones and elevated TSH levels in childhood obesity.
J Clin Res Pediatr Endocrinol. 2014; 6(2):100-4.JC

Abstract

OBJECTIVE

An elevated thyroid stimulating hormone (TSH) level is a frequent finding in obese children, but its association with peripheral hormone metabolism is not fully understood. We hypothesized that in obesity, the changes in thyroid hormone metabolism in peripheral tissues might lead to dysregulation in the thyroid axis. The purpose of this study was to investigate the association of TSH with thyroid hormones in a group of obese children as compared to normal-weight controls.

METHODS

Serum TSH, free thyroxine (fT4) and free triiodothyronine (fT3) levels were measured in 101 obese children and in 40 controls. Serum reverse T3 (rT3) levels were also measured in a subgroup of 51 obese children and in 15 controls.

RESULTS

Serum TSH level was significantly higher in obese children compared to controls (2.78 vs. 1.99 mIU/L, p<0.001), while no difference was found in fT4, fT3, rT3 levels and in fT3/rT3 ratio. In the obese group, fT3 level positively correlated with fT4 (r=0.217, p=0.033) and inversely with rT3 (r=-0.288, p=0.045). However, thyroid hormone levels and TSH levels were not correlated.

CONCLUSION

In obese children, normal fT4, fT3 and rT3 levels suggest an undisturbed peripheral hormone metabolism. These levels show no correlation with elevated TSH levels.

Authors+Show Affiliations

Comenius University Faculty of Medicine and Children's University Hospital, Department of Pediatrics, Bratislava, Slovakia. E-ma-il: ticha.lubica@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24932603

Citation

Lobotková, Denisa, et al. "Lack of Association Between Peripheral Activity of Thyroid Hormones and Elevated TSH Levels in Childhood Obesity." Journal of Clinical Research in Pediatric Endocrinology, vol. 6, no. 2, 2014, pp. 100-4.
Lobotková D, Staníková D, Staník J, et al. Lack of association between peripheral activity of thyroid hormones and elevated TSH levels in childhood obesity. J Clin Res Pediatr Endocrinol. 2014;6(2):100-4.
Lobotková, D., Staníková, D., Staník, J., Cervenová, O., Bzdúch, V., & Tichá, L. (2014). Lack of association between peripheral activity of thyroid hormones and elevated TSH levels in childhood obesity. Journal of Clinical Research in Pediatric Endocrinology, 6(2), 100-4. https://doi.org/10.4274/Jcrpe.1251
Lobotková D, et al. Lack of Association Between Peripheral Activity of Thyroid Hormones and Elevated TSH Levels in Childhood Obesity. J Clin Res Pediatr Endocrinol. 2014;6(2):100-4. PubMed PMID: 24932603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association between peripheral activity of thyroid hormones and elevated TSH levels in childhood obesity. AU - Lobotková,Denisa, AU - Staníková,Daniela, AU - Staník,Juraj, AU - Cervenová,Ol'ga, AU - Bzdúch,Vladimír, AU - Tichá,L'ubica, PY - 2014/6/17/entrez PY - 2014/6/17/pubmed PY - 2015/1/27/medline SP - 100 EP - 4 JF - Journal of clinical research in pediatric endocrinology JO - J Clin Res Pediatr Endocrinol VL - 6 IS - 2 N2 - OBJECTIVE: An elevated thyroid stimulating hormone (TSH) level is a frequent finding in obese children, but its association with peripheral hormone metabolism is not fully understood. We hypothesized that in obesity, the changes in thyroid hormone metabolism in peripheral tissues might lead to dysregulation in the thyroid axis. The purpose of this study was to investigate the association of TSH with thyroid hormones in a group of obese children as compared to normal-weight controls. METHODS: Serum TSH, free thyroxine (fT4) and free triiodothyronine (fT3) levels were measured in 101 obese children and in 40 controls. Serum reverse T3 (rT3) levels were also measured in a subgroup of 51 obese children and in 15 controls. RESULTS: Serum TSH level was significantly higher in obese children compared to controls (2.78 vs. 1.99 mIU/L, p<0.001), while no difference was found in fT4, fT3, rT3 levels and in fT3/rT3 ratio. In the obese group, fT3 level positively correlated with fT4 (r=0.217, p=0.033) and inversely with rT3 (r=-0.288, p=0.045). However, thyroid hormone levels and TSH levels were not correlated. CONCLUSION: In obese children, normal fT4, fT3 and rT3 levels suggest an undisturbed peripheral hormone metabolism. These levels show no correlation with elevated TSH levels. SN - 1308-5735 UR - https://www.unboundmedicine.com/medline/citation/24932603/Lack_of_association_between_peripheral_activity_of_thyroid_hormones_and_elevated_TSH_levels_in_childhood_obesity_ L2 - https://doi.org/10.4274/Jcrpe.1251 DB - PRIME DP - Unbound Medicine ER -