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A sensitive thyroid stimulating hormone assay for screening of thyroid functional disorder in elderly Japanese.
J Am Geriatr Soc. 1989 Apr; 37(4):317-22.JA

Abstract

The use of a screening test for thyroid functional disorder by sensitive thyroid stimulating hormone assay in the elderly was investigated. The basal thyroid stimulating hormone levels predicted the response of thyroid stimulating hormone to thyrotropin releasing hormone; it was suppressed in 99 (99.0%) of 100 hyperthyroid patients. Therefore, not only primary hypothyroidism but also hyperthyroidism can be excluded when the serum thyroid stimulating hormone levels are normal. An epidemiological study was then performed on 2,421 (76.7%) of the Japanese general population aged 40 or over recruited from the residents in Hisayama town and also in 122 residents between 20 and 40 years of age. Additional free T4 measurement was necessary in about 10% of the residents with abnormal TSH levels to confirm the diagnosis of hyperthyroidism or distinguish latent from overt hypothyroidism. There was a significant correlation between age and serum thyroid stimulating hormone levels after logarithmic conversion (r = 0.1533, P less than .001). The prevalence of thyroid dysfunction found in 1,026 males and in 1,395 females aged 40 or over was, respectively: hyperthyroidism, less than 0.1% and 0.2%, latent (subclinical) hypothyroidism, 3.2% and 5.5%, and overt hypothyroidism, 0.4% and 0.7%. We conclude that the screening with this sensitive thyroid stimulating hormone assay and additional free T4 measurement is useful for detection of patients with thyroid functional disorder.

Authors+Show Affiliations

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2493494

Citation

Okamura, K, et al. "A Sensitive Thyroid Stimulating Hormone Assay for Screening of Thyroid Functional Disorder in Elderly Japanese." Journal of the American Geriatrics Society, vol. 37, no. 4, 1989, pp. 317-22.
Okamura K, Ueda K, Sone H, et al. A sensitive thyroid stimulating hormone assay for screening of thyroid functional disorder in elderly Japanese. J Am Geriatr Soc. 1989;37(4):317-22.
Okamura, K., Ueda, K., Sone, H., Ikenoue, H., Hasuo, Y., Sato, K., Yoshinari, M., & Fujishima, M. (1989). A sensitive thyroid stimulating hormone assay for screening of thyroid functional disorder in elderly Japanese. Journal of the American Geriatrics Society, 37(4), 317-22.
Okamura K, et al. A Sensitive Thyroid Stimulating Hormone Assay for Screening of Thyroid Functional Disorder in Elderly Japanese. J Am Geriatr Soc. 1989;37(4):317-22. PubMed PMID: 2493494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A sensitive thyroid stimulating hormone assay for screening of thyroid functional disorder in elderly Japanese. AU - Okamura,K, AU - Ueda,K, AU - Sone,H, AU - Ikenoue,H, AU - Hasuo,Y, AU - Sato,K, AU - Yoshinari,M, AU - Fujishima,M, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 317 EP - 22 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 37 IS - 4 N2 - The use of a screening test for thyroid functional disorder by sensitive thyroid stimulating hormone assay in the elderly was investigated. The basal thyroid stimulating hormone levels predicted the response of thyroid stimulating hormone to thyrotropin releasing hormone; it was suppressed in 99 (99.0%) of 100 hyperthyroid patients. Therefore, not only primary hypothyroidism but also hyperthyroidism can be excluded when the serum thyroid stimulating hormone levels are normal. An epidemiological study was then performed on 2,421 (76.7%) of the Japanese general population aged 40 or over recruited from the residents in Hisayama town and also in 122 residents between 20 and 40 years of age. Additional free T4 measurement was necessary in about 10% of the residents with abnormal TSH levels to confirm the diagnosis of hyperthyroidism or distinguish latent from overt hypothyroidism. There was a significant correlation between age and serum thyroid stimulating hormone levels after logarithmic conversion (r = 0.1533, P less than .001). The prevalence of thyroid dysfunction found in 1,026 males and in 1,395 females aged 40 or over was, respectively: hyperthyroidism, less than 0.1% and 0.2%, latent (subclinical) hypothyroidism, 3.2% and 5.5%, and overt hypothyroidism, 0.4% and 0.7%. We conclude that the screening with this sensitive thyroid stimulating hormone assay and additional free T4 measurement is useful for detection of patients with thyroid functional disorder. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/2493494/A_sensitive_thyroid_stimulating_hormone_assay_for_screening_of_thyroid_functional_disorder_in_elderly_Japanese_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=1989&volume=37&issue=4&spage=317 DB - PRIME DP - Unbound Medicine ER -