Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides.Org Lett. 2014 Jul 03; 16(13):3468-71.OL
Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides.