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Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides.
Org Lett. 2014 Jul 03; 16(13):3468-71.OL

Abstract

Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides.

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Publisher Full Text (DOI)

Authors+Show Affiliations

René O
Discovery Chemistry and ‡Small Molecule Process Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Fauber BP
No affiliation info available
Malhotra S
No affiliation info available
Yajima H
No affiliation info available

MeSH

CatalysisHydrocarbons, IodinatedMagnetic Resonance SpectroscopyMolecular StructurePalladiumSulfonamides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24937120

Citation

René, Olivier, et al. "Palladium-catalyzed Α-arylation of Sultams With Aryl and Heteroaryl Iodides." Organic Letters, vol. 16, no. 13, 2014, pp. 3468-71.
René O, Fauber BP, Malhotra S, et al. Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides. Org Lett. 2014;16(13):3468-71.
René, O., Fauber, B. P., Malhotra, S., & Yajima, H. (2014). Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides. Organic Letters, 16(13), 3468-71. https://doi.org/10.1021/ol501389k
René O, et al. Palladium-catalyzed Α-arylation of Sultams With Aryl and Heteroaryl Iodides. Org Lett. 2014 Jul 3;16(13):3468-71. PubMed PMID: 24937120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides. AU - René,Olivier, AU - Fauber,Benjamin P, AU - Malhotra,Sushant, AU - Yajima,Herbert, Y1 - 2014/06/17/ PY - 2014/6/18/entrez PY - 2014/6/18/pubmed PY - 2014/9/3/medline SP - 3468 EP - 71 JF - Organic letters JO - Org Lett VL - 16 IS - 13 N2 - Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/24937120/Palladium_catalyzed_α_arylation_of_sultams_with_aryl_and_heteroaryl_iodides_ DB - PRIME DP - Unbound Medicine ER -