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Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats.
Mol Med Rep. 2014 Sep; 10(3):1400-8.MM

Abstract

This study investigated the effect of Panax notoginseng saponins (PNS) on acute lung injury (ALI) induced by oleic acid (OA) and lipopolysaccharide (LPS). A total of 28 Wistar rats were divided into four groups: sham; sham + PNS; OA‑LPS‑induced ALI and ALI + PNS. Lung tissue histology, lung wet‑to‑dry (W/D) weight ratio, extravascular lung water (EVLW) and epithelial sodium channel α (αENaC) mRNA and protein expression were examined. In addition, levels of inflammatory cytokines, including tumor necrosis factor α (TNF‑α), interleukin (IL)‑6 and IL‑10, as well as total leukocyte and neutrophil counts, were analyzed in rat bronchoalveolar lavage fluid (BALF) and serum. ALI + PNS rats were observed to exhibit significantly lower pulmonary parenchymal damage and EVLW compared with ALI rats. Furthermore, total leukocyte and neutrophil counts, and levels of inflammatory cytokines were significantly decreased following PNS administration in ALI rats. In addition, the decrease in αENaC mRNA and protein expression observed in the lung tissue of ALI rats was partially restored following PNS treatment. PNS treatment was demonstrated to ameliorate OA‑LPS‑induced ALI, potentially through restoration of αENaC mRNA and protein expression and through PNS‑induced anti‑inflammatory effects.

Authors+Show Affiliations

Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, P.R. China.Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, P.R. China.Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24938646

Citation

Chen, Yu-Qing, et al. "Anti‑inflammatory Effects of Panax Notoginseng Saponins Ameliorate Acute Lung Injury Induced By Oleic Acid and Lipopolysaccharide in Rats." Molecular Medicine Reports, vol. 10, no. 3, 2014, pp. 1400-8.
Chen YQ, Rong L, Qiao JO. Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats. Mol Med Rep. 2014;10(3):1400-8.
Chen, Y. Q., Rong, L., & Qiao, J. O. (2014). Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats. Molecular Medicine Reports, 10(3), 1400-8. https://doi.org/10.3892/mmr.2014.2328
Chen YQ, Rong L, Qiao JO. Anti‑inflammatory Effects of Panax Notoginseng Saponins Ameliorate Acute Lung Injury Induced By Oleic Acid and Lipopolysaccharide in Rats. Mol Med Rep. 2014;10(3):1400-8. PubMed PMID: 24938646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats. AU - Chen,Yu-Qing, AU - Rong,Ling, AU - Qiao,Jian-Ou, Y1 - 2014/06/16/ PY - 2013/07/16/received PY - 2014/01/22/accepted PY - 2014/6/19/entrez PY - 2014/6/19/pubmed PY - 2015/5/15/medline SP - 1400 EP - 8 JF - Molecular medicine reports JO - Mol Med Rep VL - 10 IS - 3 N2 - This study investigated the effect of Panax notoginseng saponins (PNS) on acute lung injury (ALI) induced by oleic acid (OA) and lipopolysaccharide (LPS). A total of 28 Wistar rats were divided into four groups: sham; sham + PNS; OA‑LPS‑induced ALI and ALI + PNS. Lung tissue histology, lung wet‑to‑dry (W/D) weight ratio, extravascular lung water (EVLW) and epithelial sodium channel α (αENaC) mRNA and protein expression were examined. In addition, levels of inflammatory cytokines, including tumor necrosis factor α (TNF‑α), interleukin (IL)‑6 and IL‑10, as well as total leukocyte and neutrophil counts, were analyzed in rat bronchoalveolar lavage fluid (BALF) and serum. ALI + PNS rats were observed to exhibit significantly lower pulmonary parenchymal damage and EVLW compared with ALI rats. Furthermore, total leukocyte and neutrophil counts, and levels of inflammatory cytokines were significantly decreased following PNS administration in ALI rats. In addition, the decrease in αENaC mRNA and protein expression observed in the lung tissue of ALI rats was partially restored following PNS treatment. PNS treatment was demonstrated to ameliorate OA‑LPS‑induced ALI, potentially through restoration of αENaC mRNA and protein expression and through PNS‑induced anti‑inflammatory effects. SN - 1791-3004 UR - https://www.unboundmedicine.com/medline/citation/24938646/Anti‑inflammatory_effects_of_Panax_notoginseng_saponins_ameliorate_acute_lung_injury_induced_by_oleic_acid_and_lipopolysaccharide_in_rats_ L2 - http://www.spandidos-publications.com/mmr/10/3/1400 DB - PRIME DP - Unbound Medicine ER -