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B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia.
Nutr Neurosci 2016; 19(10):461-466NN

Abstract

OBJECTIVE

An intervention study was performed to determine if supplement containing folic acid, vitamin B6, and vitamin B12 could improve cognitive function and lower homocysteine in middle-aged and elderly patients with hyperhomocysteinemia.

METHODS

One hundred and four participants with hyperhomocysteinemia were recruited in Tianjin, China, aged 55-94 years old. Fifty-seven individuals with hyperhomocysteinemia were included in the intervention group (vitamin B group, which received 800 µg/day of folate, with 10 mg of vitamin B6 and 25 µg of vitamin B12) and 47 patients in the placebo group. The endpoint was the improvement in cognitive function as evaluated by Basic Cognitive Aptitude Tests (BCATs). All parameters were measured before and after the treatment period of 14 weeks.

RESULTS

The BCAT total score and four sub-tests scores (digit copy, Chinese character rotation, digital working memory, and recognition of meaningless figure) of BCAT at 14 weeks significantly increased only for the vitamin B group. Serum total homocysteine (tHcy) levels significantly decreased in the intervention group, while serum concentrations of folate, vitamin B6, and vitamin B12 significantly increased in the intervention group.

CONCLUSION

The results demonstrated that supplement containing folate, vitamin B6, and vitamin B12 in middle-aged and elderly patients with hyperhomocysteinemia could improve their cognitive function partly and reduce serum tHcy levels.

Authors+Show Affiliations

a Department of Nutrition , Tianjin Institute of Health and Environmental Medicine , Tianjin , China. b Department of Nutrition and Food Safety , West China School of Public Health, Sichuan University , Chengdu , China. c Department of Public Health , Chengdu Medical College , Chengdu , China.b Department of Nutrition and Food Safety , West China School of Public Health, Sichuan University , Chengdu , China.a Department of Nutrition , Tianjin Institute of Health and Environmental Medicine , Tianjin , China.a Department of Nutrition , Tianjin Institute of Health and Environmental Medicine , Tianjin , China.d Center for Disease Control and Prevention , PLA Chengdu Military Area Command, Chengdu , China.b Department of Nutrition and Food Safety , West China School of Public Health, Sichuan University , Chengdu , China.a Department of Nutrition , Tianjin Institute of Health and Environmental Medicine , Tianjin , China.

Pub Type(s)

Controlled Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

24938711

Citation

Cheng, Daomei, et al. "B Vitamin Supplementation Improves Cognitive Function in the Middle Aged and Elderly With Hyperhomocysteinemia." Nutritional Neuroscience, vol. 19, no. 10, 2016, pp. 461-466.
Cheng D, Kong H, Pang W, et al. B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci. 2016;19(10):461-466.
Cheng, D., Kong, H., Pang, W., Yang, H., Lu, H., Huang, C., & Jiang, Y. (2016). B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutritional Neuroscience, 19(10), pp. 461-466.
Cheng D, et al. B Vitamin Supplementation Improves Cognitive Function in the Middle Aged and Elderly With Hyperhomocysteinemia. Nutr Neurosci. 2016;19(10):461-466. PubMed PMID: 24938711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. AU - Cheng,Daomei, AU - Kong,Haiyan, AU - Pang,Wei, AU - Yang,Hongpeng, AU - Lu,Hao, AU - Huang,Chengyu, AU - Jiang,Yugang, Y1 - 2016/03/02/ PY - 2014/6/19/pubmed PY - 2017/3/11/medline PY - 2014/6/19/entrez KW - B vitamins KW - Cognition KW - Homocysteine KW - Hyperhomocysteinemia KW - The middle aged and elderly SP - 461 EP - 466 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 19 IS - 10 N2 - OBJECTIVE: An intervention study was performed to determine if supplement containing folic acid, vitamin B6, and vitamin B12 could improve cognitive function and lower homocysteine in middle-aged and elderly patients with hyperhomocysteinemia. METHODS: One hundred and four participants with hyperhomocysteinemia were recruited in Tianjin, China, aged 55-94 years old. Fifty-seven individuals with hyperhomocysteinemia were included in the intervention group (vitamin B group, which received 800 µg/day of folate, with 10 mg of vitamin B6 and 25 µg of vitamin B12) and 47 patients in the placebo group. The endpoint was the improvement in cognitive function as evaluated by Basic Cognitive Aptitude Tests (BCATs). All parameters were measured before and after the treatment period of 14 weeks. RESULTS: The BCAT total score and four sub-tests scores (digit copy, Chinese character rotation, digital working memory, and recognition of meaningless figure) of BCAT at 14 weeks significantly increased only for the vitamin B group. Serum total homocysteine (tHcy) levels significantly decreased in the intervention group, while serum concentrations of folate, vitamin B6, and vitamin B12 significantly increased in the intervention group. CONCLUSION: The results demonstrated that supplement containing folate, vitamin B6, and vitamin B12 in middle-aged and elderly patients with hyperhomocysteinemia could improve their cognitive function partly and reduce serum tHcy levels. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/24938711/B_vitamin_supplementation_improves_cognitive_function_in_the_middle_aged_and_elderly_with_hyperhomocysteinemia_ L2 - http://www.tandfonline.com/doi/full/10.1179/1476830514Y.0000000136 DB - PRIME DP - Unbound Medicine ER -