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Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease.
Hum Brain Mapp. 2014 Nov; 35(11):5431-41.HB

Abstract

Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine-dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP-CIT positron emission tomography imaging and resting-state functional connectivity in 23 drug naïve de novo patients with PD to elucidate dopamine-dependent functional networks. The major finding is that the patterns of dopamine-dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine-dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine-dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine-dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine-dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian-related motor and cognitive performance.

Authors+Show Affiliations

Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24938993

Citation

Baik, KyoungWon, et al. "Dopaminergic Modulation of Resting-state Functional Connectivity in De Novo Patients With Parkinson's Disease." Human Brain Mapping, vol. 35, no. 11, 2014, pp. 5431-41.
Baik K, Cha J, Ham JH, et al. Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease. Hum Brain Mapp. 2014;35(11):5431-41.
Baik, K., Cha, J., Ham, J. H., Baek, G. M., Sunwoo, M. K., Hong, J. Y., Shin, N. Y., Kim, J. S., Lee, J. M., Lee, S. K., Sohn, Y. H., & Lee, P. H. (2014). Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease. Human Brain Mapping, 35(11), 5431-41. https://doi.org/10.1002/hbm.22561
Baik K, et al. Dopaminergic Modulation of Resting-state Functional Connectivity in De Novo Patients With Parkinson's Disease. Hum Brain Mapp. 2014;35(11):5431-41. PubMed PMID: 24938993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease. AU - Baik,KyoungWon, AU - Cha,Jungho, AU - Ham,Jee Hyun, AU - Baek,Gwang-Min, AU - Sunwoo,Mun Kyung, AU - Hong,Jin Yong, AU - Shin,Na-Young, AU - Kim,Jae Seung, AU - Lee,Jong-Min, AU - Lee,Seung-Koo, AU - Sohn,Young Ho, AU - Lee,Phil Hyu, Y1 - 2014/06/17/ PY - 2013/12/02/received PY - 2014/05/12/revised PY - 2014/05/20/accepted PY - 2014/6/19/entrez PY - 2014/6/19/pubmed PY - 2015/6/16/medline KW - de novo Parkinson's disease KW - dopamine KW - resting-state functional connectivity SP - 5431 EP - 41 JF - Human brain mapping JO - Hum Brain Mapp VL - 35 IS - 11 N2 - Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine-dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP-CIT positron emission tomography imaging and resting-state functional connectivity in 23 drug naïve de novo patients with PD to elucidate dopamine-dependent functional networks. The major finding is that the patterns of dopamine-dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine-dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine-dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine-dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine-dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian-related motor and cognitive performance. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/24938993/Dopaminergic_modulation_of_resting_state_functional_connectivity_in_de_novo_patients_with_Parkinson's_disease_ L2 - https://doi.org/10.1002/hbm.22561 DB - PRIME DP - Unbound Medicine ER -