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Reference interval determination for anabasine: a biomarker of active tobacco use.
J Anal Toxicol. 2014 Sep; 38(7):416-20.JA

Abstract

Laboratory detection of nicotine exposure is important for establishing eligibility for organ transplant and elective surgery. Nicotine testing is also used to verify compliance with nicotine replacement therapies (NRT), smoking cessation programs and for life insurance purposes. Nicotine metabolites, such as cotinine and trans-3'-hydroxycotinine, are used as biomarkers of nicotine exposure. For some clinical applications, it is important to distinguish between active use of tobacco products versus NRT. Anabasine is a tobacco alkaloid that has been used as a biomarker of active tobacco use. However, the use of anabasine as an insecticide, and its presence in consumables other than nicotine products, suggests that anabasine may not be specific to tobacco use/exposure. Here, we determine the reference interval for anabasine in the urine of nonsmokers and compare it to the range of anabasine concentrations observed in the presence or absence of nicotine metabolites.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Suh-Lailam BB
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Haglock-Adler CJ
ARUP Laboratories, Salt Lake City, UT 84108, USA.
Carlisle HJ
ARUP Laboratories, Salt Lake City, UT 84108, USA.
Ohman T
ARUP Laboratories, Salt Lake City, UT 84108, USA.
McMillin GA
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA ARUP Laboratories, Salt Lake City, UT 84108, USA gwen.mcmillin@aruplab.com.

MeSH

AnabasineBiomarkersCalibrationChromatography, LiquidFemaleHealthy VolunteersHumansMaleNicotinePatient ComplianceReference ValuesReproducibility of ResultsSmokingSmoking CessationSubstance Abuse DetectionSurveys and QuestionnairesTandem Mass SpectrometryTobacco Use Cessation Devices

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24939383

Citation

Suh-Lailam, Brenda B., et al. "Reference Interval Determination for Anabasine: a Biomarker of Active Tobacco Use." Journal of Analytical Toxicology, vol. 38, no. 7, 2014, pp. 416-20.
Suh-Lailam BB, Haglock-Adler CJ, Carlisle HJ, et al. Reference interval determination for anabasine: a biomarker of active tobacco use. J Anal Toxicol. 2014;38(7):416-20.
Suh-Lailam, B. B., Haglock-Adler, C. J., Carlisle, H. J., Ohman, T., & McMillin, G. A. (2014). Reference interval determination for anabasine: a biomarker of active tobacco use. Journal of Analytical Toxicology, 38(7), 416-20. https://doi.org/10.1093/jat/bku059
Suh-Lailam BB, et al. Reference Interval Determination for Anabasine: a Biomarker of Active Tobacco Use. J Anal Toxicol. 2014;38(7):416-20. PubMed PMID: 24939383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reference interval determination for anabasine: a biomarker of active tobacco use. AU - Suh-Lailam,Brenda B, AU - Haglock-Adler,Carrie J, AU - Carlisle,Heidi J, AU - Ohman,Trent, AU - McMillin,Gwendolyn A, Y1 - 2014/06/17/ PY - 2014/6/19/entrez PY - 2014/6/19/pubmed PY - 2015/4/9/medline SP - 416 EP - 20 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 38 IS - 7 N2 - Laboratory detection of nicotine exposure is important for establishing eligibility for organ transplant and elective surgery. Nicotine testing is also used to verify compliance with nicotine replacement therapies (NRT), smoking cessation programs and for life insurance purposes. Nicotine metabolites, such as cotinine and trans-3'-hydroxycotinine, are used as biomarkers of nicotine exposure. For some clinical applications, it is important to distinguish between active use of tobacco products versus NRT. Anabasine is a tobacco alkaloid that has been used as a biomarker of active tobacco use. However, the use of anabasine as an insecticide, and its presence in consumables other than nicotine products, suggests that anabasine may not be specific to tobacco use/exposure. Here, we determine the reference interval for anabasine in the urine of nonsmokers and compare it to the range of anabasine concentrations observed in the presence or absence of nicotine metabolites. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/24939383/Reference_interval_determination_for_anabasine:_a_biomarker_of_active_tobacco_use_ DB - PRIME DP - Unbound Medicine ER -