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Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts.
Drug Res (Stuttg). 2015 May; 65(5):259-65.DR

Abstract

2 new flavonoid glycosides, kaempferol 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (1) and quercetin 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (2), were isolated from the n-butanol soluble fraction of the methanol extract (BF) of Astragalus abyssinicus aerial parts, together with 3 known compounds, rutin (3), kaempferol 3-O-β-D-rutinoside (4) and 5,7,4'-trihydroxy-3'-methoxyisoflavone (5). The structures of the isolated compounds were characterized on the basis of UV, NMR and negative ESI-MS analyses. The BF fraction showed in vitro weak antibacterial activity against Staphylococcus aureus, while 2 and 3 exhibited in vitro antioxidant activity higher than ascorbic acid using DPPH free radical scavenging activity method.

Authors+Show Affiliations

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh Saudi Arabia.Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt.Department of Pharmacognosy, College of Pharmacy, Al-Azhar University, Cairo, Egypt.Department of Pharmacognosy, College of Pharmacy, Najran Univeristy, Najran, Kingdom of Saudi Arabia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24941085

Citation

El Dib, R A., et al. "Two New Flavonoids and Biological Activity of Astragalus Abyssinicus (Hochst.) Steud. Ex A. Rich. Aerial Parts." Drug Research, vol. 65, no. 5, 2015, pp. 259-65.
El Dib RA, Soliman HS, Hussein MH, et al. Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts. Drug Res (Stuttg). 2015;65(5):259-65.
El Dib, R. A., Soliman, H. S., Hussein, M. H., & Attia, H. G. (2015). Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts. Drug Research, 65(5), 259-65. https://doi.org/10.1055/s-0034-1377003
El Dib RA, et al. Two New Flavonoids and Biological Activity of Astragalus Abyssinicus (Hochst.) Steud. Ex A. Rich. Aerial Parts. Drug Res (Stuttg). 2015;65(5):259-65. PubMed PMID: 24941085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts. AU - El Dib,R A, AU - Soliman,H S M, AU - Hussein,M H, AU - Attia,H G, Y1 - 2014/06/18/ PY - 2014/6/19/entrez PY - 2014/6/19/pubmed PY - 2016/4/20/medline SP - 259 EP - 65 JF - Drug research JO - Drug Res (Stuttg) VL - 65 IS - 5 N2 - 2 new flavonoid glycosides, kaempferol 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (1) and quercetin 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (2), were isolated from the n-butanol soluble fraction of the methanol extract (BF) of Astragalus abyssinicus aerial parts, together with 3 known compounds, rutin (3), kaempferol 3-O-β-D-rutinoside (4) and 5,7,4'-trihydroxy-3'-methoxyisoflavone (5). The structures of the isolated compounds were characterized on the basis of UV, NMR and negative ESI-MS analyses. The BF fraction showed in vitro weak antibacterial activity against Staphylococcus aureus, while 2 and 3 exhibited in vitro antioxidant activity higher than ascorbic acid using DPPH free radical scavenging activity method. SN - 2194-9387 UR - https://www.unboundmedicine.com/medline/citation/24941085/Two_New_Flavonoids_and_Biological_Activity_of_Astragalus_abyssinicus__Hochst___Steud__ex_A__Rich__Aerial_Parts_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0034-1377003 DB - PRIME DP - Unbound Medicine ER -