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Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts.
Drug Res (Stuttg). 2015 May; 65(5):259-65.DR

Abstract

2 new flavonoid glycosides, kaempferol 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (1) and quercetin 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (2), were isolated from the n-butanol soluble fraction of the methanol extract (BF) of Astragalus abyssinicus aerial parts, together with 3 known compounds, rutin (3), kaempferol 3-O-β-D-rutinoside (4) and 5,7,4'-trihydroxy-3'-methoxyisoflavone (5). The structures of the isolated compounds were characterized on the basis of UV, NMR and negative ESI-MS analyses. The BF fraction showed in vitro weak antibacterial activity against Staphylococcus aureus, while 2 and 3 exhibited in vitro antioxidant activity higher than ascorbic acid using DPPH free radical scavenging activity method.

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Publisher Full Text (DOI)

Authors+Show Affiliations

El Dib RA
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh Saudi Arabia.
Soliman HS
Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Hussein MH
Department of Pharmacognosy, College of Pharmacy, Al-Azhar University, Cairo, Egypt.
Attia HG
Department of Pharmacognosy, College of Pharmacy, Najran Univeristy, Najran, Kingdom of Saudi Arabia.

MeSH

AntioxidantsAstragalus PlantFlavonoidsGlycosidesKaempferolsMicrobial Sensitivity TestsMolecular StructurePlant Components, AerialPlant ExtractsQuercetinTrisaccharides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24941085

Citation

El Dib, R A., et al. "Two New Flavonoids and Biological Activity of Astragalus Abyssinicus (Hochst.) Steud. Ex A. Rich. Aerial Parts." Drug Research, vol. 65, no. 5, 2015, pp. 259-65.
El Dib RA, Soliman HS, Hussein MH, et al. Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts. Drug Res (Stuttg). 2015;65(5):259-65.
El Dib, R. A., Soliman, H. S., Hussein, M. H., & Attia, H. G. (2015). Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts. Drug Research, 65(5), 259-65. https://doi.org/10.1055/s-0034-1377003
El Dib RA, et al. Two New Flavonoids and Biological Activity of Astragalus Abyssinicus (Hochst.) Steud. Ex A. Rich. Aerial Parts. Drug Res (Stuttg). 2015;65(5):259-65. PubMed PMID: 24941085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts. AU - El Dib,R A, AU - Soliman,H S M, AU - Hussein,M H, AU - Attia,H G, Y1 - 2014/06/18/ PY - 2014/6/19/entrez PY - 2014/6/19/pubmed PY - 2016/4/20/medline SP - 259 EP - 65 JF - Drug research JO - Drug Res (Stuttg) VL - 65 IS - 5 N2 - 2 new flavonoid glycosides, kaempferol 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (1) and quercetin 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (2), were isolated from the n-butanol soluble fraction of the methanol extract (BF) of Astragalus abyssinicus aerial parts, together with 3 known compounds, rutin (3), kaempferol 3-O-β-D-rutinoside (4) and 5,7,4'-trihydroxy-3'-methoxyisoflavone (5). The structures of the isolated compounds were characterized on the basis of UV, NMR and negative ESI-MS analyses. The BF fraction showed in vitro weak antibacterial activity against Staphylococcus aureus, while 2 and 3 exhibited in vitro antioxidant activity higher than ascorbic acid using DPPH free radical scavenging activity method. SN - 2194-9387 UR - https://www.unboundmedicine.com/medline/citation/24941085/Two_New_Flavonoids_and_Biological_Activity_of_Astragalus_abyssinicus__Hochst___Steud__ex_A__Rich__Aerial_Parts_ DB - PRIME DP - Unbound Medicine ER -