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Numerical simulations of deformation and aggregation of red blood cells in shear flow.
Crit Rev Biomed Eng 2013; 41(4-5):425-34CR

Abstract

This article reviews numerical simulations of red blood cells (RBCs) mainly using the lattice Boltzmann method (LBM), focusing on the 2-dimensional deformation and aggregation of the cells in simple shear flow. We outline the incorporation of the immersed boundary method into the LBM, in which the membrane forces are obtained from the membrane model. The RBCs are simulated as a single biconcave capsule and as a doublet of biconcave capsules. The transition from swinging to tumbling motions of the RBCs, as induced by reducing the shear rate or increasing the membrane bending stiffness, is discussed. Also discussed is the aggregation tendency of the doublet of RBCs, for which homogenous deformability maintained RBC aggregation, whereas an increased deformability difference resulted in RBC dissociation.

Authors+Show Affiliations

Division of Bioengineering, Department of Mechanical Engineering, National University of Singapore, Singapore 117576.Department of Biomedical Engineering, National University of Singapore, Singapore.School of Engineering and Materials Science, Queen Mary University of London, London, United Kingdom.Department of Mechanical Engineering, National University of Singapore, Singapore.Department of Biomedical Engineering, National University of Singapore, Singapore.Department of Bioengineering, National University of Singapore, Singapore 117575.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24941417

Citation

Low, Hong-Tong, et al. "Numerical Simulations of Deformation and Aggregation of Red Blood Cells in Shear Flow." Critical Reviews in Biomedical Engineering, vol. 41, no. 4-5, 2013, pp. 425-34.
Low HT, Ju M, Sui Y, et al. Numerical simulations of deformation and aggregation of red blood cells in shear flow. Crit Rev Biomed Eng. 2013;41(4-5):425-34.
Low, H. T., Ju, M., Sui, Y., Nazir, T., Namgung, B., & Kim, S. (2013). Numerical simulations of deformation and aggregation of red blood cells in shear flow. Critical Reviews in Biomedical Engineering, 41(4-5), pp. 425-34.
Low HT, et al. Numerical Simulations of Deformation and Aggregation of Red Blood Cells in Shear Flow. Crit Rev Biomed Eng. 2013;41(4-5):425-34. PubMed PMID: 24941417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Numerical simulations of deformation and aggregation of red blood cells in shear flow. AU - Low,Hong-Tong, AU - Ju,M, AU - Sui,Y, AU - Nazir,T, AU - Namgung,B, AU - Kim,Sangho, PY - 2014/6/19/entrez PY - 2013/1/1/pubmed PY - 2014/7/18/medline SP - 425 EP - 34 JF - Critical reviews in biomedical engineering JO - Crit Rev Biomed Eng VL - 41 IS - 4-5 N2 - This article reviews numerical simulations of red blood cells (RBCs) mainly using the lattice Boltzmann method (LBM), focusing on the 2-dimensional deformation and aggregation of the cells in simple shear flow. We outline the incorporation of the immersed boundary method into the LBM, in which the membrane forces are obtained from the membrane model. The RBCs are simulated as a single biconcave capsule and as a doublet of biconcave capsules. The transition from swinging to tumbling motions of the RBCs, as induced by reducing the shear rate or increasing the membrane bending stiffness, is discussed. Also discussed is the aggregation tendency of the doublet of RBCs, for which homogenous deformability maintained RBC aggregation, whereas an increased deformability difference resulted in RBC dissociation. SN - 0278-940X UR - https://www.unboundmedicine.com/medline/citation/24941417/Numerical_simulations_of_deformation_and_aggregation_of_red_blood_cells_in_shear_flow_ L2 - http://www.begellhouse.com/journals/4b27cbfc562e21b8,4566441101015d3d,59366cb16b464556.html DB - PRIME DP - Unbound Medicine ER -