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Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study.
BJOG. 2015 Feb; 122(3):304-11.BJOG

Abstract

OBJECTIVE

Compared with western populations, the consumption of soy foods among Japanese is very high and the incidence of endometrial cancer very low. We evaluated the association of soy food and isoflavone intake with endometrial cancer risk in Japanese women.

DESIGN

Prospective cohort study.

SETTING

Ten public health centre areas in Japan.

POPULATION

Forty nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey questionnaire.

METHODS

Intakes of soy foods as well as other covariates were assessed in 1995-1998 by a self-administered food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI).

MAIN OUTCOME MEASURE

Incidence of endometrial cancer.

RESULTS

During an average of 12.1 years of follow up, 112 newly diagnosed endometrial cancer cases were identified. Energy-adjusted intakes of soy food and isoflavone were not associated with the risk of endometrial cancer. The multivariate-adjusted HR per 25 g/day increase in the intake of soy food was 1.02 (95% CI 0.94-1.10), and the corresponding value for isoflavone intake per 15 mg/day was 1.01 (95% CI 0.84-1.22).

CONCLUSION

In this population-based prospective cohort study of Japanese women, we observed no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk.

Authors+Show Affiliations

Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24941880

Citation

Budhathoki, S, et al. "Soy Food and Isoflavone Intake and Endometrial Cancer Risk: the Japan Public Health Center-based Prospective Study." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 122, no. 3, 2015, pp. 304-11.
Budhathoki S, Iwasaki M, Sawada N, et al. Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. BJOG. 2015;122(3):304-11.
Budhathoki, S., Iwasaki, M., Sawada, N., Yamaji, T., Shimazu, T., Sasazuki, S., Inoue, M., & Tsugane, S. (2015). Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. BJOG : an International Journal of Obstetrics and Gynaecology, 122(3), 304-11. https://doi.org/10.1111/1471-0528.12853
Budhathoki S, et al. Soy Food and Isoflavone Intake and Endometrial Cancer Risk: the Japan Public Health Center-based Prospective Study. BJOG. 2015;122(3):304-11. PubMed PMID: 24941880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. AU - Budhathoki,S, AU - Iwasaki,M, AU - Sawada,N, AU - Yamaji,T, AU - Shimazu,T, AU - Sasazuki,S, AU - Inoue,M, AU - Tsugane,S, AU - ,, Y1 - 2014/06/18/ PY - 2014/02/01/accepted PY - 2014/6/20/entrez PY - 2014/6/20/pubmed PY - 2015/5/16/medline KW - Endometrial cancer risk KW - epidemiology KW - isoflavone KW - prospective study KW - soy food SP - 304 EP - 11 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 122 IS - 3 N2 - OBJECTIVE: Compared with western populations, the consumption of soy foods among Japanese is very high and the incidence of endometrial cancer very low. We evaluated the association of soy food and isoflavone intake with endometrial cancer risk in Japanese women. DESIGN: Prospective cohort study. SETTING: Ten public health centre areas in Japan. POPULATION: Forty nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey questionnaire. METHODS: Intakes of soy foods as well as other covariates were assessed in 1995-1998 by a self-administered food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). MAIN OUTCOME MEASURE: Incidence of endometrial cancer. RESULTS: During an average of 12.1 years of follow up, 112 newly diagnosed endometrial cancer cases were identified. Energy-adjusted intakes of soy food and isoflavone were not associated with the risk of endometrial cancer. The multivariate-adjusted HR per 25 g/day increase in the intake of soy food was 1.02 (95% CI 0.94-1.10), and the corresponding value for isoflavone intake per 15 mg/day was 1.01 (95% CI 0.84-1.22). CONCLUSION: In this population-based prospective cohort study of Japanese women, we observed no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/24941880/Soy_food_and_isoflavone_intake_and_endometrial_cancer_risk:_the_Japan_Public_Health_Center_based_prospective_study_ L2 - https://doi.org/10.1111/1471-0528.12853 DB - PRIME DP - Unbound Medicine ER -