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The role of the adaptive immune system in regulation of gut microbiota.
Immunol Rev 2014; 260(1):67-75IR

Abstract

The gut nourishes rich bacterial communities that affect profoundly the functions of the immune system. The relationship between gut microbiota and the immune system is one of reciprocity. The microbiota contributes to nutrient processing and the development, maturation, and function of the immune system. Conversely, the immune system, particularly the adaptive immune system, plays a key role in shaping the repertoire of gut microbiota. The fitness of host immune system is reflected in the gut microbiota, and deficiencies in either innate or adaptive immunity impact on diversity and structures of bacterial communities in the gut. Here, we discuss the mechanisms that underlie this reciprocity and emphasize how the adaptive immune system via immunoglobulins (i.e. IgA) contributes to diversification and balance of gut microbiota required for immune homeostasis.

Authors+Show Affiliations

Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences (IMS-RCAI), RIKEN Yokohama Institute, Yokohama, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24942682

Citation

Kato, Lucia M., et al. "The Role of the Adaptive Immune System in Regulation of Gut Microbiota." Immunological Reviews, vol. 260, no. 1, 2014, pp. 67-75.
Kato LM, Kawamoto S, Maruya M, et al. The role of the adaptive immune system in regulation of gut microbiota. Immunol Rev. 2014;260(1):67-75.
Kato, L. M., Kawamoto, S., Maruya, M., & Fagarasan, S. (2014). The role of the adaptive immune system in regulation of gut microbiota. Immunological Reviews, 260(1), pp. 67-75. doi:10.1111/imr.12185.
Kato LM, et al. The Role of the Adaptive Immune System in Regulation of Gut Microbiota. Immunol Rev. 2014;260(1):67-75. PubMed PMID: 24942682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the adaptive immune system in regulation of gut microbiota. AU - Kato,Lucia M, AU - Kawamoto,Shimpei, AU - Maruya,Mikako, AU - Fagarasan,Sidonia, PY - 2014/6/20/entrez PY - 2014/6/20/pubmed PY - 2015/1/30/medline KW - Foxp3 KW - IgA KW - PD-1 KW - bacteria KW - germinal center SP - 67 EP - 75 JF - Immunological reviews JO - Immunol. Rev. VL - 260 IS - 1 N2 - The gut nourishes rich bacterial communities that affect profoundly the functions of the immune system. The relationship between gut microbiota and the immune system is one of reciprocity. The microbiota contributes to nutrient processing and the development, maturation, and function of the immune system. Conversely, the immune system, particularly the adaptive immune system, plays a key role in shaping the repertoire of gut microbiota. The fitness of host immune system is reflected in the gut microbiota, and deficiencies in either innate or adaptive immunity impact on diversity and structures of bacterial communities in the gut. Here, we discuss the mechanisms that underlie this reciprocity and emphasize how the adaptive immune system via immunoglobulins (i.e. IgA) contributes to diversification and balance of gut microbiota required for immune homeostasis. SN - 1600-065X UR - https://www.unboundmedicine.com/medline/citation/24942682/The_role_of_the_adaptive_immune_system_in_regulation_of_gut_microbiota_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-2896&date=2014&volume=260&spage=67 DB - PRIME DP - Unbound Medicine ER -