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2012-2013 Seasonal influenza vaccine effectiveness against influenza hospitalizations: results from the global influenza hospital surveillance network.
PLoS One 2014; 9(6):e100497Plos

Abstract

BACKGROUND

The effectiveness of currently licensed vaccines against influenza has not been clearly established, especially among individuals at increased risk for complications from influenza. We used a test-negative approach to estimate influenza vaccine effectiveness (IVE) against hospitalization with laboratory-confirmed influenza based on data collected from the Global Influenza Hospital Surveillance Network (GIHSN).

METHODS AND FINDINGS

This was a multi-center, prospective, active surveillance, hospital-based epidemiological study during the 2012-2013 influenza season. Data were collected from hospitals participating in the GIHSN, including five in Spain, five in France, and four in the Russian Federation. Influenza was confirmed by reverse transcription-polymerase chain reaction. IVE against hospitalization for laboratory-confirmed influenza was estimated for adult patients targeted for vaccination and who were swabbed within 7 days of symptom onset. The overall adjusted IVE was 33% (95% confidence interval [CI], 11% to 49%). Point estimates of IVE were 23% (95% CI, -26% to 53%) for influenza A(H1N1)pdm09, 30% (95% CI, -37% to 64%) for influenza A(H3N2), and 43% (95% CI, 17% to 60%) for influenza B/Yamagata. IVE estimates were similar in subjects <65 and ≥65 years of age (35% [95% CI, -15% to 63%] vs.31% [95% CI, 4% to 51%]). Heterogeneity in site-specific IVE estimates was high (I2 = 63.4%) for A(H1N1)pdm09 in patients ≥65 years of age. IVE estimates for influenza B/Yamagata were homogenous (I2 = 0.0%).

CONCLUSIONS

These results, which were based on data collected from the GIHSN during the 2012-2013 influenza season, showed that influenza vaccines provided low to moderate protection against hospital admission with laboratory-confirmed influenza in adults targeted for influenza vaccination. In this population, IVE estimates against A(H1N1)pdm09 were sensitive to age group and study site. Influenza vaccination was moderately effective in preventing admissions with influenza B/Yamagata for all sites and age groups.

Authors+Show Affiliations

Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO - Public Health, Valencia, Spain.Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO - Public Health, Valencia, Spain.Université Paris Descartes, Sorbonne Paris Cité, Inserm, CIC 1417 and the French Vaccine Research Network (REIVAC), Paris, France.D.I. Ivanovsky Institute of Virology, Moscow, Russian Federation.National Influenza Reference Laboratory Cappa-Istanbul, Istanbul, Turkey.Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO - Public Health, Valencia, Spain.Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO - Public Health, Valencia, Spain.Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO - Public Health, Valencia, Spain.Research Institute of Influenza, St. Petersburg, Russian Federation.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

24945510

Citation

Puig-Barberà, Joan, et al. "2012-2013 Seasonal Influenza Vaccine Effectiveness Against Influenza Hospitalizations: Results From the Global Influenza Hospital Surveillance Network." PloS One, vol. 9, no. 6, 2014, pp. e100497.
Puig-Barberà J, Natividad-Sancho A, Launay O, et al. 2012-2013 Seasonal influenza vaccine effectiveness against influenza hospitalizations: results from the global influenza hospital surveillance network. PLoS ONE. 2014;9(6):e100497.
Puig-Barberà, J., Natividad-Sancho, A., Launay, O., Burtseva, E., Ciblak, M. A., Tormos, A., ... Sominina, A. (2014). 2012-2013 Seasonal influenza vaccine effectiveness against influenza hospitalizations: results from the global influenza hospital surveillance network. PloS One, 9(6), pp. e100497. doi:10.1371/journal.pone.0100497.
Puig-Barberà J, et al. 2012-2013 Seasonal Influenza Vaccine Effectiveness Against Influenza Hospitalizations: Results From the Global Influenza Hospital Surveillance Network. PLoS ONE. 2014;9(6):e100497. PubMed PMID: 24945510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 2012-2013 Seasonal influenza vaccine effectiveness against influenza hospitalizations: results from the global influenza hospital surveillance network. AU - Puig-Barberà,Joan, AU - Natividad-Sancho,Angels, AU - Launay,Odile, AU - Burtseva,Elena, AU - Ciblak,Meral A, AU - Tormos,Anita, AU - Buigues-Vila,Amparo, AU - Martínez-Úbeda,Sergio, AU - Sominina,Anna, AU - ,, Y1 - 2014/06/19/ PY - 2014/02/24/received PY - 2014/05/24/accepted PY - 2014/6/20/entrez PY - 2014/6/20/pubmed PY - 2015/3/13/medline SP - e100497 EP - e100497 JF - PloS one JO - PLoS ONE VL - 9 IS - 6 N2 - BACKGROUND: The effectiveness of currently licensed vaccines against influenza has not been clearly established, especially among individuals at increased risk for complications from influenza. We used a test-negative approach to estimate influenza vaccine effectiveness (IVE) against hospitalization with laboratory-confirmed influenza based on data collected from the Global Influenza Hospital Surveillance Network (GIHSN). METHODS AND FINDINGS: This was a multi-center, prospective, active surveillance, hospital-based epidemiological study during the 2012-2013 influenza season. Data were collected from hospitals participating in the GIHSN, including five in Spain, five in France, and four in the Russian Federation. Influenza was confirmed by reverse transcription-polymerase chain reaction. IVE against hospitalization for laboratory-confirmed influenza was estimated for adult patients targeted for vaccination and who were swabbed within 7 days of symptom onset. The overall adjusted IVE was 33% (95% confidence interval [CI], 11% to 49%). Point estimates of IVE were 23% (95% CI, -26% to 53%) for influenza A(H1N1)pdm09, 30% (95% CI, -37% to 64%) for influenza A(H3N2), and 43% (95% CI, 17% to 60%) for influenza B/Yamagata. IVE estimates were similar in subjects <65 and ≥65 years of age (35% [95% CI, -15% to 63%] vs.31% [95% CI, 4% to 51%]). Heterogeneity in site-specific IVE estimates was high (I2 = 63.4%) for A(H1N1)pdm09 in patients ≥65 years of age. IVE estimates for influenza B/Yamagata were homogenous (I2 = 0.0%). CONCLUSIONS: These results, which were based on data collected from the GIHSN during the 2012-2013 influenza season, showed that influenza vaccines provided low to moderate protection against hospital admission with laboratory-confirmed influenza in adults targeted for influenza vaccination. In this population, IVE estimates against A(H1N1)pdm09 were sensitive to age group and study site. Influenza vaccination was moderately effective in preventing admissions with influenza B/Yamagata for all sites and age groups. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24945510/2012_2013_Seasonal_influenza_vaccine_effectiveness_against_influenza_hospitalizations:_results_from_the_global_influenza_hospital_surveillance_network_ L2 - http://dx.plos.org/10.1371/journal.pone.0100497 DB - PRIME DP - Unbound Medicine ER -