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Impact of dose on the bioavailability of coffee chlorogenic acids in humans.
Food Funct. 2014 Aug; 5(8):1727-37.FF

Abstract

Single servings of coffee beverage containing low (412 μmol), medium (635 μmol) and high (795 μmol) amounts of chlorogenic acids were administered to eleven healthy volunteers in a double-blind randomised controlled trial. Analysis of plasma and urine collected for 24 h revealed the presence of 12 metabolites in plasma and 16 metabolites in urine, principally in the form of sulphates, and to a lesser extent glucuronides of caffeic, ferulic, dihydrocaffeic and dihydroferulic acids, as well as intact feruloylquinic and caffeoylquinic acids, and sulphated caffeoylquinic acid lactones. Median values of peak plasma concentrations after increasing doses of chlorogenic acids were 1088, 1526 and 1352 nM. In urine the median amounts of metabolites excreted after 24 h following consumption of the three coffees were 101, 160 and 125 μmol, accounting for 24%, 25% and 16% of the doses ingested. Peak plasma concentration and urinary excretion values showed trends towards a reduced bioavailability of chlorogenic acids associated with the highest dose ingested, when expressed as percentages of intake. Potential biomarkers of coffee intake were identified as feruloylquinic acids and sulphated caffeoylquinic acid lactones in plasma and urine with positive moderate to strong coefficients of determination for peak plasma concentrations (0.60-0.81) and amounts excreted in urine (0.36-0.73) (P < 0.05).

Authors+Show Affiliations

Plant Products and Human Nutrition Group, Joseph Black Building, School of Medicine, College of Biomedical, Veterinary and Life Sciences, University of Glasgow, UK. alan.crozier@glasgow.ac.uk.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24947504

Citation

Stalmach, Angélique, et al. "Impact of Dose On the Bioavailability of Coffee Chlorogenic Acids in Humans." Food & Function, vol. 5, no. 8, 2014, pp. 1727-37.
Stalmach A, Williamson G, Crozier A. Impact of dose on the bioavailability of coffee chlorogenic acids in humans. Food Funct. 2014;5(8):1727-37.
Stalmach, A., Williamson, G., & Crozier, A. (2014). Impact of dose on the bioavailability of coffee chlorogenic acids in humans. Food & Function, 5(8), 1727-37. https://doi.org/10.1039/c4fo00316k
Stalmach A, Williamson G, Crozier A. Impact of Dose On the Bioavailability of Coffee Chlorogenic Acids in Humans. Food Funct. 2014;5(8):1727-37. PubMed PMID: 24947504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of dose on the bioavailability of coffee chlorogenic acids in humans. AU - Stalmach,Angélique, AU - Williamson,Gary, AU - Crozier,Alan, PY - 2014/6/21/entrez PY - 2014/6/21/pubmed PY - 2015/3/31/medline SP - 1727 EP - 37 JF - Food & function JO - Food Funct VL - 5 IS - 8 N2 - Single servings of coffee beverage containing low (412 μmol), medium (635 μmol) and high (795 μmol) amounts of chlorogenic acids were administered to eleven healthy volunteers in a double-blind randomised controlled trial. Analysis of plasma and urine collected for 24 h revealed the presence of 12 metabolites in plasma and 16 metabolites in urine, principally in the form of sulphates, and to a lesser extent glucuronides of caffeic, ferulic, dihydrocaffeic and dihydroferulic acids, as well as intact feruloylquinic and caffeoylquinic acids, and sulphated caffeoylquinic acid lactones. Median values of peak plasma concentrations after increasing doses of chlorogenic acids were 1088, 1526 and 1352 nM. In urine the median amounts of metabolites excreted after 24 h following consumption of the three coffees were 101, 160 and 125 μmol, accounting for 24%, 25% and 16% of the doses ingested. Peak plasma concentration and urinary excretion values showed trends towards a reduced bioavailability of chlorogenic acids associated with the highest dose ingested, when expressed as percentages of intake. Potential biomarkers of coffee intake were identified as feruloylquinic acids and sulphated caffeoylquinic acid lactones in plasma and urine with positive moderate to strong coefficients of determination for peak plasma concentrations (0.60-0.81) and amounts excreted in urine (0.36-0.73) (P < 0.05). SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/24947504/Impact_of_dose_on_the_bioavailability_of_coffee_chlorogenic_acids_in_humans_ L2 - https://doi.org/10.1039/c4fo00316k DB - PRIME DP - Unbound Medicine ER -