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Similar age-related decline in cortical activity over frontotemporal regions in schizophrenia: a multichannel near-infrared spectroscopy study.
Schizophr Bull 2015; 41(1):268-79SB

Abstract

OBJECTIVES

Although recent studies have demonstrated that patients with schizophrenia and healthy controls did not differ in the speed of age-related decline in cortical thickness and performances on cognitive tests, hemodynamic changes assessed by functional neuroimaging remain unclear. This study investigated age effects on regional brain cortical activity to determine whether there is similar age-related decline in cortical activity as those observed in cortical thickness and cognitive test performance.

METHOD

A total of 109 patients with schizophrenia (age range: 16-59 y) and 106 healthy controls (age range: 16-59 y) underwent near-infrared spectroscopy (NIRS) while performing a verbal fluency test (VFT). Group comparison of cortical activity was examined using 2-tailed t tests, adopting the false discovery rate method. The relationship between age and cortical activity was investigated using correlational and multiple regression analyses, adjusting for potential confounding variables. A 2-way ANOVA was conducted to investigate differences in the age effects between diagnostic groups.

RESULTS

The patient group exhibited significantly decreased cortical activity in several regions of the frontotemporal cortices. However, slopes of age-dependent decreases in cortical activity were similar between patients and healthy individuals at the bilateral frontotemporal regions.

CONCLUSIONS

Our study showed no significant between-group differences in the age-related decline in cortical activity, as measured by NIRS, over the frontotemporal regions during a VFT. The results of our study may indicate a decrease in cortical activity in a relatively limited period around illness onset rather than continuously progressing over the course of the illness.

Authors+Show Affiliations

Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan; Department of Psychiatry, Taichung Veterans General Hospital, Taichung City, Taiwan;Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan; Division for Counseling and Support, Office for Mental Health Support, University of Tokyo, Bunkyo-ku, Tokyo, Japan;Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan;Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan;Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan;Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan; kasaik-tky@umin.net.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24948388

Citation

Chou, Po-Han, et al. "Similar Age-related Decline in Cortical Activity Over Frontotemporal Regions in Schizophrenia: a Multichannel Near-infrared Spectroscopy Study." Schizophrenia Bulletin, vol. 41, no. 1, 2015, pp. 268-79.
Chou PH, Koike S, Nishimura Y, et al. Similar age-related decline in cortical activity over frontotemporal regions in schizophrenia: a multichannel near-infrared spectroscopy study. Schizophr Bull. 2015;41(1):268-79.
Chou, P. H., Koike, S., Nishimura, Y., Satomura, Y., Kinoshita, A., Takizawa, R., & Kasai, K. (2015). Similar age-related decline in cortical activity over frontotemporal regions in schizophrenia: a multichannel near-infrared spectroscopy study. Schizophrenia Bulletin, 41(1), pp. 268-79. doi:10.1093/schbul/sbu086.
Chou PH, et al. Similar Age-related Decline in Cortical Activity Over Frontotemporal Regions in Schizophrenia: a Multichannel Near-infrared Spectroscopy Study. Schizophr Bull. 2015;41(1):268-79. PubMed PMID: 24948388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Similar age-related decline in cortical activity over frontotemporal regions in schizophrenia: a multichannel near-infrared spectroscopy study. AU - Chou,Po-Han, AU - Koike,Shinsuke, AU - Nishimura,Yukika, AU - Satomura,Yoshihiro, AU - Kinoshita,Akihide, AU - Takizawa,Ryu, AU - Kasai,Kiyoto, Y1 - 2014/06/19/ PY - 2014/6/21/entrez PY - 2014/6/21/pubmed PY - 2015/8/19/medline KW - NIRS KW - age effect KW - near infrared spectroscopy KW - schizophrenia SP - 268 EP - 79 JF - Schizophrenia bulletin JO - Schizophr Bull VL - 41 IS - 1 N2 - OBJECTIVES: Although recent studies have demonstrated that patients with schizophrenia and healthy controls did not differ in the speed of age-related decline in cortical thickness and performances on cognitive tests, hemodynamic changes assessed by functional neuroimaging remain unclear. This study investigated age effects on regional brain cortical activity to determine whether there is similar age-related decline in cortical activity as those observed in cortical thickness and cognitive test performance. METHOD: A total of 109 patients with schizophrenia (age range: 16-59 y) and 106 healthy controls (age range: 16-59 y) underwent near-infrared spectroscopy (NIRS) while performing a verbal fluency test (VFT). Group comparison of cortical activity was examined using 2-tailed t tests, adopting the false discovery rate method. The relationship between age and cortical activity was investigated using correlational and multiple regression analyses, adjusting for potential confounding variables. A 2-way ANOVA was conducted to investigate differences in the age effects between diagnostic groups. RESULTS: The patient group exhibited significantly decreased cortical activity in several regions of the frontotemporal cortices. However, slopes of age-dependent decreases in cortical activity were similar between patients and healthy individuals at the bilateral frontotemporal regions. CONCLUSIONS: Our study showed no significant between-group differences in the age-related decline in cortical activity, as measured by NIRS, over the frontotemporal regions during a VFT. The results of our study may indicate a decrease in cortical activity in a relatively limited period around illness onset rather than continuously progressing over the course of the illness. SN - 1745-1701 UR - https://www.unboundmedicine.com/medline/citation/24948388/Similar_age_related_decline_in_cortical_activity_over_frontotemporal_regions_in_schizophrenia:_a_multichannel_near_infrared_spectroscopy_study_ L2 - https://academic.oup.com/schizophreniabulletin/article-lookup/doi/10.1093/schbul/sbu086 DB - PRIME DP - Unbound Medicine ER -