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Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain.
Biochim Biophys Acta 2014; 1842(9):1693-706BB

Abstract

Alzheimer disease (AD) is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition. Epidemiological data show that the incidence of AD increases with age and doubles every 5 years after 65 years of age. From a neuropathological point of view, amyloid-β-peptide (Aβ) leads to senile plaques, which, together with hyperphosphorylated tau-based neurofibrillary tangles and synapse loss, are the principal pathological hallmarks of AD. Aβ is associated with the formation of reactive oxygen (ROS) and nitrogen (RNS) species, and induces calcium-dependent excitotoxicity, impairment of cellular respiration, and alteration of synaptic functions associated with learning and memory. Oxidative stress was found to be associated with type 2 diabetes mellitus (T2DM), which (i) represents another prevalent disease associated with obesity and often aging, and (ii) is considered to be a risk factor for AD development. T2DM is characterized by high blood glucose levels resulting from increased hepatic glucose production, impaired insulin production and peripheral insulin resistance, which close resemble to the brain insulin resistance observed in AD patients. Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of insulin resistance and vice versa. This review article provides molecular aspects and the pharmacological approaches from both preclinical and clinical data interpreted from the point of view of oxidative stress with the aim of highlighting progresses in this field.

Authors+Show Affiliations

Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506-0055, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506-0055, USA. Electronic address: dabcns@uky.edu.Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24949886

Citation

Butterfield, D Allan, et al. "Elevated Risk of Type 2 Diabetes for Development of Alzheimer Disease: a Key Role for Oxidative Stress in Brain." Biochimica Et Biophysica Acta, vol. 1842, no. 9, 2014, pp. 1693-706.
Butterfield DA, Di Domenico F, Barone E. Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. Biochim Biophys Acta. 2014;1842(9):1693-706.
Butterfield, D. A., Di Domenico, F., & Barone, E. (2014). Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. Biochimica Et Biophysica Acta, 1842(9), pp. 1693-706. doi:10.1016/j.bbadis.2014.06.010.
Butterfield DA, Di Domenico F, Barone E. Elevated Risk of Type 2 Diabetes for Development of Alzheimer Disease: a Key Role for Oxidative Stress in Brain. Biochim Biophys Acta. 2014;1842(9):1693-706. PubMed PMID: 24949886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. AU - Butterfield,D Allan, AU - Di Domenico,Fabio, AU - Barone,Eugenio, Y1 - 2014/06/17/ PY - 2014/05/01/received PY - 2014/06/05/revised PY - 2014/06/09/accepted PY - 2014/6/21/entrez PY - 2014/6/21/pubmed PY - 2014/9/26/medline KW - Alzheimer disease KW - Heme oxygenase 1 and biliverdin reductase KW - Insulin KW - Oxidative stress KW - Protein oxidation KW - Type-2 diabetes mellitus and insulin resistance SP - 1693 EP - 706 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1842 IS - 9 N2 - Alzheimer disease (AD) is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition. Epidemiological data show that the incidence of AD increases with age and doubles every 5 years after 65 years of age. From a neuropathological point of view, amyloid-β-peptide (Aβ) leads to senile plaques, which, together with hyperphosphorylated tau-based neurofibrillary tangles and synapse loss, are the principal pathological hallmarks of AD. Aβ is associated with the formation of reactive oxygen (ROS) and nitrogen (RNS) species, and induces calcium-dependent excitotoxicity, impairment of cellular respiration, and alteration of synaptic functions associated with learning and memory. Oxidative stress was found to be associated with type 2 diabetes mellitus (T2DM), which (i) represents another prevalent disease associated with obesity and often aging, and (ii) is considered to be a risk factor for AD development. T2DM is characterized by high blood glucose levels resulting from increased hepatic glucose production, impaired insulin production and peripheral insulin resistance, which close resemble to the brain insulin resistance observed in AD patients. Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of insulin resistance and vice versa. This review article provides molecular aspects and the pharmacological approaches from both preclinical and clinical data interpreted from the point of view of oxidative stress with the aim of highlighting progresses in this field. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/24949886/Elevated_risk_of_type_2_diabetes_for_development_of_Alzheimer_disease:_a_key_role_for_oxidative_stress_in_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(14)00175-6 DB - PRIME DP - Unbound Medicine ER -