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Two cases of primary cutaneous lymphoma with a γ/δ+ phenotype and an indolent course: further evidence of heterogeneity of cutaneous γ/δ+ T-cell lymphomas.
Am J Dermatopathol 2014; 36(7):570-7AJ

Abstract

Cutaneous γ/δ+ T-cell lymphoma (CGD-TCL) is a rare but aggressive lymphoma associated with a poor prognosis in most patients. The clinicopathological spectrum is variable including predominantly epidermotropic infiltrates manifesting with patches and plaques or tumors with dermal and/or subcutaneous infiltrates. The diagnosis of CGD-TCL requires the demonstration of a γ/δ+ phenotype by immunohistochemistry. We report 2 patients with epidermotropic cutaneous T-cell lymphomas displaying a γ/δ+ phenotype, but exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-to-medium-sized lymphocytes. These cases corroborate the view that expression of a γ/δ+ phenotype in cutaneous T-cell lymphomas per se does not portend a worse prognosis and that CGD-TCL may represent a clinically and prognostically heterogeneous group.

Authors+Show Affiliations

*Kempf Und Pfaltz Histologische Diagnostik, Zürich, Switzerland; †Department of Pathology, Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic; ‡Dermatology Practice, Brugg, Switzerland; and §Department of Dermatology, University of Cologne, Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24950419

Citation

Kempf, Werner, et al. "Two Cases of Primary Cutaneous Lymphoma With a Γ/δ+ Phenotype and an Indolent Course: Further Evidence of Heterogeneity of Cutaneous Γ/δ+ T-cell Lymphomas." The American Journal of Dermatopathology, vol. 36, no. 7, 2014, pp. 570-7.
Kempf W, Kazakov DV, Scheidegger PE, et al. Two cases of primary cutaneous lymphoma with a γ/δ+ phenotype and an indolent course: further evidence of heterogeneity of cutaneous γ/δ+ T-cell lymphomas. Am J Dermatopathol. 2014;36(7):570-7.
Kempf, W., Kazakov, D. V., Scheidegger, P. E., Schlaak, M., & Tantcheva-Poor, I. (2014). Two cases of primary cutaneous lymphoma with a γ/δ+ phenotype and an indolent course: further evidence of heterogeneity of cutaneous γ/δ+ T-cell lymphomas. The American Journal of Dermatopathology, 36(7), pp. 570-7. doi:10.1097/DAD.0000000000000029.
Kempf W, et al. Two Cases of Primary Cutaneous Lymphoma With a Γ/δ+ Phenotype and an Indolent Course: Further Evidence of Heterogeneity of Cutaneous Γ/δ+ T-cell Lymphomas. Am J Dermatopathol. 2014;36(7):570-7. PubMed PMID: 24950419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two cases of primary cutaneous lymphoma with a γ/δ+ phenotype and an indolent course: further evidence of heterogeneity of cutaneous γ/δ+ T-cell lymphomas. AU - Kempf,Werner, AU - Kazakov,Dmitry V, AU - Scheidegger,Paul E, AU - Schlaak,Max, AU - Tantcheva-Poor,Iliana, PY - 2014/6/21/entrez PY - 2014/6/21/pubmed PY - 2015/2/20/medline SP - 570 EP - 7 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 36 IS - 7 N2 - Cutaneous γ/δ+ T-cell lymphoma (CGD-TCL) is a rare but aggressive lymphoma associated with a poor prognosis in most patients. The clinicopathological spectrum is variable including predominantly epidermotropic infiltrates manifesting with patches and plaques or tumors with dermal and/or subcutaneous infiltrates. The diagnosis of CGD-TCL requires the demonstration of a γ/δ+ phenotype by immunohistochemistry. We report 2 patients with epidermotropic cutaneous T-cell lymphomas displaying a γ/δ+ phenotype, but exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-to-medium-sized lymphocytes. These cases corroborate the view that expression of a γ/δ+ phenotype in cutaneous T-cell lymphomas per se does not portend a worse prognosis and that CGD-TCL may represent a clinically and prognostically heterogeneous group. SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/24950419/Two_cases_of_primary_cutaneous_lymphoma_with_a_γ/δ+_phenotype_and_an_indolent_course:_further_evidence_of_heterogeneity_of_cutaneous_γ/δ+_T_cell_lymphomas_ L2 - http://dx.doi.org/10.1097/DAD.0000000000000029 DB - PRIME DP - Unbound Medicine ER -