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Importance of MRI in the diagnosis of vertebral involvement in generalized cystic lymphangiomatosis.
Skeletal Radiol. 2014 Nov; 43(11):1633-8.SR

Abstract

A 9-year-old boy presented with the sudden onset of pleuritic chest pain and on CT was found to have a large pleural effusion, mediastinal fluid, splenic lesions and multiple apparently sclerotic vertebral bodies. Subsequent MRI showed that those vertebral bodies that appeared sclerotic were in fact normal, and the vertebral bodies initially interpreted as normal had an abnormal T1 and T2 hyperintense signal on MRI and were relatively lucent on CT. MRI also demonstrated abnormal heterogeneous T2 hyperintense paraspinal tissue and several multicystic soft tissue masses. Biopsy of two adjacent vertebral bodies, one relatively sclerotic and one lucent, demonstrated findings of bony remodeling without a specific diagnosis. Biopsy of an infiltrative mediastinal mass confirmed the diagnosis of generalized cystic lymphangiomatosis. MRI should be included in the assessment of vertebral involvement in this condition because CT and biopsy findings may be nonspecific.

Authors+Show Affiliations

Department of Radiology, New York Presbyterian Hospital/Weill Cornell Medical Center, 525 East 68th Street, New York, NY, 10065, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24950879

Citation

Renjen, Pooja, et al. "Importance of MRI in the Diagnosis of Vertebral Involvement in Generalized Cystic Lymphangiomatosis." Skeletal Radiology, vol. 43, no. 11, 2014, pp. 1633-8.
Renjen P, Kovanlikaya A, Narula N, et al. Importance of MRI in the diagnosis of vertebral involvement in generalized cystic lymphangiomatosis. Skeletal Radiol. 2014;43(11):1633-8.
Renjen, P., Kovanlikaya, A., Narula, N., & Brill, P. W. (2014). Importance of MRI in the diagnosis of vertebral involvement in generalized cystic lymphangiomatosis. Skeletal Radiology, 43(11), 1633-8. https://doi.org/10.1007/s00256-014-1935-1
Renjen P, et al. Importance of MRI in the Diagnosis of Vertebral Involvement in Generalized Cystic Lymphangiomatosis. Skeletal Radiol. 2014;43(11):1633-8. PubMed PMID: 24950879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Importance of MRI in the diagnosis of vertebral involvement in generalized cystic lymphangiomatosis. AU - Renjen,Pooja, AU - Kovanlikaya,Arzu, AU - Narula,Navneet, AU - Brill,Paula W, Y1 - 2014/06/21/ PY - 2014/01/22/received PY - 2014/06/01/accepted PY - 2014/04/30/revised PY - 2014/6/22/entrez PY - 2014/6/22/pubmed PY - 2015/5/23/medline SP - 1633 EP - 8 JF - Skeletal radiology JO - Skeletal Radiol. VL - 43 IS - 11 N2 - A 9-year-old boy presented with the sudden onset of pleuritic chest pain and on CT was found to have a large pleural effusion, mediastinal fluid, splenic lesions and multiple apparently sclerotic vertebral bodies. Subsequent MRI showed that those vertebral bodies that appeared sclerotic were in fact normal, and the vertebral bodies initially interpreted as normal had an abnormal T1 and T2 hyperintense signal on MRI and were relatively lucent on CT. MRI also demonstrated abnormal heterogeneous T2 hyperintense paraspinal tissue and several multicystic soft tissue masses. Biopsy of two adjacent vertebral bodies, one relatively sclerotic and one lucent, demonstrated findings of bony remodeling without a specific diagnosis. Biopsy of an infiltrative mediastinal mass confirmed the diagnosis of generalized cystic lymphangiomatosis. MRI should be included in the assessment of vertebral involvement in this condition because CT and biopsy findings may be nonspecific. SN - 1432-2161 UR - https://www.unboundmedicine.com/medline/citation/24950879/Importance_of_MRI_in_the_diagnosis_of_vertebral_involvement_in_generalized_cystic_lymphangiomatosis_ L2 - https://dx.doi.org/10.1007/s00256-014-1935-1 DB - PRIME DP - Unbound Medicine ER -