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Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography.
BMC Neurol. 2014 Jun 20; 14:136.BN

Abstract

BACKGROUND

Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in 18F-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis.

METHODS

The brain 18F-fluoro-2-deoxy-d-glucose uptake from whole-body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and four patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls.

RESULTS

Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti-leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism.

CONCLUSIONS

This retrospective 18F-fluoro-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis.

Authors+Show Affiliations

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str, 1, 30625 Hannover, Germany. wegner.florian@mh-hannover.de.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24950993

Citation

Wegner, Florian, et al. "Anti-leucine Rich Glioma Inactivated 1 Protein and anti-N-methyl-D-aspartate Receptor Encephalitis Show Distinct Patterns of Brain Glucose Metabolism in 18F-fluoro-2-deoxy-d-glucose Positron Emission Tomography." BMC Neurology, vol. 14, 2014, p. 136.
Wegner F, Wilke F, Raab P, et al. Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography. BMC Neurol. 2014;14:136.
Wegner, F., Wilke, F., Raab, P., Tayeb, S. B., Boeck, A. L., Haense, C., Trebst, C., Voss, E., Schrader, C., Logemann, F., Ahrens, J., Leffler, A., Rodriguez-Raecke, R., Dengler, R., Geworski, L., Bengel, F. M., Berding, G., Stangel, M., & Nabavi, E. (2014). Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography. BMC Neurology, 14, 136. https://doi.org/10.1186/1471-2377-14-136
Wegner F, et al. Anti-leucine Rich Glioma Inactivated 1 Protein and anti-N-methyl-D-aspartate Receptor Encephalitis Show Distinct Patterns of Brain Glucose Metabolism in 18F-fluoro-2-deoxy-d-glucose Positron Emission Tomography. BMC Neurol. 2014 Jun 20;14:136. PubMed PMID: 24950993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography. AU - Wegner,Florian, AU - Wilke,Florian, AU - Raab,Peter, AU - Tayeb,Said Ben, AU - Boeck,Anna-Lena, AU - Haense,Cathleen, AU - Trebst,Corinna, AU - Voss,Elke, AU - Schrader,Christoph, AU - Logemann,Frank, AU - Ahrens,Jörg, AU - Leffler,Andreas, AU - Rodriguez-Raecke,Rea, AU - Dengler,Reinhard, AU - Geworski,Lilli, AU - Bengel,Frank M, AU - Berding,Georg, AU - Stangel,Martin, AU - Nabavi,Elham, Y1 - 2014/06/20/ PY - 2014/01/15/received PY - 2014/06/17/accepted PY - 2014/6/22/entrez PY - 2014/6/22/pubmed PY - 2015/1/17/medline SP - 136 EP - 136 JF - BMC neurology JO - BMC Neurol VL - 14 N2 - BACKGROUND: Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in 18F-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis. METHODS: The brain 18F-fluoro-2-deoxy-d-glucose uptake from whole-body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and four patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls. RESULTS: Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti-leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism. CONCLUSIONS: This retrospective 18F-fluoro-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/24950993/Anti_leucine_rich_glioma_inactivated_1_protein_and_anti_N_methyl_D_aspartate_receptor_encephalitis_show_distinct_patterns_of_brain_glucose_metabolism_in_18F_fluoro_2_deoxy_d_glucose_positron_emission_tomography_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-14-136 DB - PRIME DP - Unbound Medicine ER -