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Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review.
Maturitas. 2014 Aug; 78(4):263-76.M

Abstract

AIMS

Review controlled clinical trials of isoflavones and amino acid preparation effects on hot flashes and at least one other symptom including mood, sleep, pain, and cognitive function that women report during the menopausal transition and early postmenopause.

METHODS

An experienced reference librarian searched PubMed/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for English-language randomized controlled trials between 2004 and July 2011. Seventeen trials of isoflavones and amino acid effects on hot flashes and one additional symptom were identified.

RESULTS

In five trials of soy isoflavone preparations, two (6g soy germ extract and 25 g soy protein in soy nuts) significantly decreased hot flashes, but no other symptoms. In the seven trials of other isoflavones, six significantly reduced hot flashes; in addition, red clover (80 mg) significantly reduced mood symptoms; Rexflavone (350 mg) for women with Kupperman Index>20 significantly reduced sleep symptoms; two trials had significant reductions for pain: isoflavone powder (90 mg) and red clover (80 mg). The only trial in this systematic review that significantly reduced cognitive symptoms was red clover (80 mg). In one trial, red clover isoflavone (80 mg/day) significantly relieved hot flashes, mood, pain, and cognitive symptoms. Amino acids yielded no significant results. Equol supplements of 30 mg/day for non-Equol producing women significantly reduced mood symptoms in one trial. The magnolia bark extract combination significantly reduced hot flashes, mood, and sleep symptoms.

CONCLUSIONS

Isoflavone trials yielded significant reductions on hot flashes and co-occurring symptoms during the menopausal transition and postmenopause, but studies require replication with larger sample sizes and attention to measurement of outcomes.

Links

PMC Free PDF

Authors+Show Affiliations

Thomas AJ
University of Washington School of Nursing, United States. Electronic address: ajthomas@uw.edu.
Ismail R
University of Washington School of Nursing, United States and Ministry of Health, Republic of Indonesia, United States.
Taylor-Swanson L
University of Washington School of Nursing, United States.
Cray L
College of Nursing, Seattle University, United States.
Schnall JG
Health Sciences Library, University of Washington, United States.
Mitchell ES
Family and Child Nursing, University of Washington, United States.
Woods NF
Biobehavioral Nursing and Health Systems, University of Washington, United States.

MeSH

AffectAmino AcidsCognition DisordersFemaleHot FlashesHumansIsoflavonesMenopausePainPhytoestrogensPostmenopauseSleep Wake Disorders

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review
Systematic Review

Language

eng

PubMed ID

24951101

Citation

Thomas, Annette J., et al. "Effects of Isoflavones and Amino Acid Therapies for Hot Flashes and Co-occurring Symptoms During the Menopausal Transition and Early Postmenopause: a Systematic Review." Maturitas, vol. 78, no. 4, 2014, pp. 263-76.
Thomas AJ, Ismail R, Taylor-Swanson L, et al. Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review. Maturitas. 2014;78(4):263-76.
Thomas, A. J., Ismail, R., Taylor-Swanson, L., Cray, L., Schnall, J. G., Mitchell, E. S., & Woods, N. F. (2014). Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review. Maturitas, 78(4), 263-76. https://doi.org/10.1016/j.maturitas.2014.05.007
Thomas AJ, et al. Effects of Isoflavones and Amino Acid Therapies for Hot Flashes and Co-occurring Symptoms During the Menopausal Transition and Early Postmenopause: a Systematic Review. Maturitas. 2014;78(4):263-76. PubMed PMID: 24951101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review. AU - Thomas,Annette J, AU - Ismail,Rita, AU - Taylor-Swanson,Lisa, AU - Cray,Lori, AU - Schnall,Janet G, AU - Mitchell,Ellen Sullivan, AU - Woods,Nancy Fugate, Y1 - 2014/05/28/ PY - 2014/05/14/received PY - 2014/05/15/accepted PY - 2014/6/22/entrez PY - 2014/6/22/pubmed PY - 2015/3/31/medline KW - Amino acids KW - Hot flashes KW - Isoflavones KW - Menopausal transition KW - Soy KW - Symptom clusters SP - 263 EP - 76 JF - Maturitas JO - Maturitas VL - 78 IS - 4 N2 - AIMS: Review controlled clinical trials of isoflavones and amino acid preparation effects on hot flashes and at least one other symptom including mood, sleep, pain, and cognitive function that women report during the menopausal transition and early postmenopause. METHODS: An experienced reference librarian searched PubMed/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for English-language randomized controlled trials between 2004 and July 2011. Seventeen trials of isoflavones and amino acid effects on hot flashes and one additional symptom were identified. RESULTS: In five trials of soy isoflavone preparations, two (6g soy germ extract and 25 g soy protein in soy nuts) significantly decreased hot flashes, but no other symptoms. In the seven trials of other isoflavones, six significantly reduced hot flashes; in addition, red clover (80 mg) significantly reduced mood symptoms; Rexflavone (350 mg) for women with Kupperman Index>20 significantly reduced sleep symptoms; two trials had significant reductions for pain: isoflavone powder (90 mg) and red clover (80 mg). The only trial in this systematic review that significantly reduced cognitive symptoms was red clover (80 mg). In one trial, red clover isoflavone (80 mg/day) significantly relieved hot flashes, mood, pain, and cognitive symptoms. Amino acids yielded no significant results. Equol supplements of 30 mg/day for non-Equol producing women significantly reduced mood symptoms in one trial. The magnolia bark extract combination significantly reduced hot flashes, mood, and sleep symptoms. CONCLUSIONS: Isoflavone trials yielded significant reductions on hot flashes and co-occurring symptoms during the menopausal transition and postmenopause, but studies require replication with larger sample sizes and attention to measurement of outcomes. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/24951101/full_citation DB - PRIME DP - Unbound Medicine ER -