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Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries.
Parkinsonism Relat Disord. 2014 Sep; 20(9):969-74.PR

Abstract

BACKGROUND

Little is known about the relationship between specific subtypes of treatment-associated motor complications and different domains of health-related Quality of Life (QoL) in patients with Parkinson's disease (PD). Larger studies that investigate these aspects within a cross-cultural setting are scarce.

OBJECTIVE

To assess QoL and its association with on-off fluctuations, peak-dose dyskinesias, biphasic dyskinesias, and off-dystonias in PD patients from five European countries.

METHODS

Data from 817 PD patients were collected cross-sectionally in France, Germany, Italy, Spain, and the UK. QoL was measured with the generic EuroQoL 5-Dimension questionnaire (EQ-5D) and the disease-specific Parkinson's Disease Questionnaire-39 (PDQ-39). Multivariable linear regression analyses were performed to test the associations of motor complication subtypes with QoL.

RESULTS

Thirty-three percent of the patients (varying from 23% in Italy to 58% in France) suffered from motor complications, either a single subtype or a combination of different subtypes. On-off fluctuations were associated with a 7.1 percentage point decrease in the EQ-5D (p < 0.001) and a 3.6 percentage point deterioration in the PDQ-39 (p = 0.01). Dyskinesias were not seen to affect global QoL scores, but had detrimental effects on the PDQ-39 dimensions activities of daily living, cognitions, stigma, and bodily discomfort. Patients from Spain, Italy, and France had lower global QoL scores in the multivariable analyses than patients from Germany and the UK.

CONCLUSION

Motor complications, primarily on-off fluctuations, may impact QoL in PD patients. This substantiates the importance of clinical strategies targeting the prevention, delay of onset, and management of motor complications in PD patients.

Authors+Show Affiliations

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre, Johannes Gutenberg University Mainz, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: hechtner@uni-mainz.de.Department of Neurology, University Medical Centre, Johannes Gutenberg University Mainz, Germany.Department of Health Sciences, Faculty of Life Sciences, Hamburg University of Applied Sciences (HAW), Germany.Department of Neurology, Skåne University Hospital, Lund, Sweden.Department of Psychology, University of Georgia, Athens, GA, USA.Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre, Johannes Gutenberg University Mainz, Germany.Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre, Johannes Gutenberg University Mainz, Germany; Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Germany.Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Hannover Medical School, Hannover, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24953743

Citation

Hechtner, Marlene C., et al. "Quality of Life in Parkinson's Disease Patients With Motor Fluctuations and Dyskinesias in Five European Countries." Parkinsonism & Related Disorders, vol. 20, no. 9, 2014, pp. 969-74.
Hechtner MC, Vogt T, Zöllner Y, et al. Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries. Parkinsonism Relat Disord. 2014;20(9):969-74.
Hechtner, M. C., Vogt, T., Zöllner, Y., Schröder, S., Sauer, J. B., Binder, H., Singer, S., & Mikolajczyk, R. (2014). Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries. Parkinsonism & Related Disorders, 20(9), 969-74. https://doi.org/10.1016/j.parkreldis.2014.06.001
Hechtner MC, et al. Quality of Life in Parkinson's Disease Patients With Motor Fluctuations and Dyskinesias in Five European Countries. Parkinsonism Relat Disord. 2014;20(9):969-74. PubMed PMID: 24953743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries. AU - Hechtner,Marlene C, AU - Vogt,Thomas, AU - Zöllner,York, AU - Schröder,Sabrina, AU - Sauer,Julia B, AU - Binder,Harald, AU - Singer,Susanne, AU - Mikolajczyk,Rafael, Y1 - 2014/06/10/ PY - 2013/12/10/received PY - 2014/05/21/revised PY - 2014/06/01/accepted PY - 2014/6/24/entrez PY - 2014/6/24/pubmed PY - 2015/12/15/medline KW - Dyskinesia KW - Europe KW - Motor complications KW - Motor fluctuations KW - Parkinson's disease KW - Quality of life SP - 969 EP - 74 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 20 IS - 9 N2 - BACKGROUND: Little is known about the relationship between specific subtypes of treatment-associated motor complications and different domains of health-related Quality of Life (QoL) in patients with Parkinson's disease (PD). Larger studies that investigate these aspects within a cross-cultural setting are scarce. OBJECTIVE: To assess QoL and its association with on-off fluctuations, peak-dose dyskinesias, biphasic dyskinesias, and off-dystonias in PD patients from five European countries. METHODS: Data from 817 PD patients were collected cross-sectionally in France, Germany, Italy, Spain, and the UK. QoL was measured with the generic EuroQoL 5-Dimension questionnaire (EQ-5D) and the disease-specific Parkinson's Disease Questionnaire-39 (PDQ-39). Multivariable linear regression analyses were performed to test the associations of motor complication subtypes with QoL. RESULTS: Thirty-three percent of the patients (varying from 23% in Italy to 58% in France) suffered from motor complications, either a single subtype or a combination of different subtypes. On-off fluctuations were associated with a 7.1 percentage point decrease in the EQ-5D (p < 0.001) and a 3.6 percentage point deterioration in the PDQ-39 (p = 0.01). Dyskinesias were not seen to affect global QoL scores, but had detrimental effects on the PDQ-39 dimensions activities of daily living, cognitions, stigma, and bodily discomfort. Patients from Spain, Italy, and France had lower global QoL scores in the multivariable analyses than patients from Germany and the UK. CONCLUSION: Motor complications, primarily on-off fluctuations, may impact QoL in PD patients. This substantiates the importance of clinical strategies targeting the prevention, delay of onset, and management of motor complications in PD patients. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/24953743/Quality_of_life_in_Parkinson's_disease_patients_with_motor_fluctuations_and_dyskinesias_in_five_European_countries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(14)00219-3 DB - PRIME DP - Unbound Medicine ER -