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Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials.
Ann Allergy Asthma Immunol. 2014 Aug; 113(2):217-26.AA

Abstract

BACKGROUND

The effects of probiotics on the treatment of atopic dermatitis (AD) are inconclusive.

OBJECTIVE

To determine the clinical effect of probiotics in the management of AD overall and in different age groups.

METHODS

A comprehensive search of databases through December 2013 was performed. For this meta-analysis, randomized controlled trials measuring the treatment effects of probiotics or synbiotics in patients diagnosed with AD were included. The primary outcome was a difference in Scoring of Atopic Dermatitis (SCORAD) values between the treatment and placebo groups overall and in different age populations.

RESULTS

Twenty-five randomized controlled trials (n = 1,599) were available for this meta-analysis. Significant differences in SCORAD values favoring probiotics over the control were observed overall (mean -4.51, 95% confidence interval -6.78 to -2.24), in children 1 to 18 years old (-5.74, 95% confidence interval -7.27 to -4.20), and in adults (-8.26, 95% confidence interval -13.28 to -3.25). However, the effectiveness of probiotics in infants (<1 year old) with AD was not proved. The effect of synbiotic use was not significantly different from that of probiotic use. Treatment with a mixture of different bacterial species or of Lactobacillus species showed greater benefit than did treatment with Bifidobacterium species alone.

CONCLUSION

The overall result of this meta-analysis suggests that probiotics could be an option for the treatment of AD, especially for moderate to severe AD in children and adults. However, no evidence was found supporting the beneficial role of probiotics in infants.

Authors+Show Affiliations

College of Pharmacy, Seoul National University, Seoul, South Korea.College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, South Korea.College of Pharmacy, Seoul National University, Seoul, South Korea.College of Pharmacy, Suncheon University, Suncheon, Joellanam-do, South Korea.College of Pharmacy, Seoul National University, Seoul, South Korea.College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, South Korea. Electronic address: jypharm@hanyang.ac.kr.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24954372

Citation

Kim, Soo-Ok, et al. "Effects of Probiotics for the Treatment of Atopic Dermatitis: a Meta-analysis of Randomized Controlled Trials." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 113, no. 2, 2014, pp. 217-26.
Kim SO, Ah YM, Yu YM, et al. Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. Ann Allergy Asthma Immunol. 2014;113(2):217-26.
Kim, S. O., Ah, Y. M., Yu, Y. M., Choi, K. H., Shin, W. G., & Lee, J. Y. (2014). Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 113(2), 217-26. https://doi.org/10.1016/j.anai.2014.05.021
Kim SO, et al. Effects of Probiotics for the Treatment of Atopic Dermatitis: a Meta-analysis of Randomized Controlled Trials. Ann Allergy Asthma Immunol. 2014;113(2):217-26. PubMed PMID: 24954372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. AU - Kim,Soo-Ok, AU - Ah,Young-Mi, AU - Yu,Yun Mi, AU - Choi,Kyung Hee, AU - Shin,Wan-Gyoon, AU - Lee,Ju-Yeun, Y1 - 2014/06/20/ PY - 2014/03/19/received PY - 2014/05/22/revised PY - 2014/05/27/accepted PY - 2014/6/24/entrez PY - 2014/6/24/pubmed PY - 2014/10/8/medline SP - 217 EP - 26 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 113 IS - 2 N2 - BACKGROUND: The effects of probiotics on the treatment of atopic dermatitis (AD) are inconclusive. OBJECTIVE: To determine the clinical effect of probiotics in the management of AD overall and in different age groups. METHODS: A comprehensive search of databases through December 2013 was performed. For this meta-analysis, randomized controlled trials measuring the treatment effects of probiotics or synbiotics in patients diagnosed with AD were included. The primary outcome was a difference in Scoring of Atopic Dermatitis (SCORAD) values between the treatment and placebo groups overall and in different age populations. RESULTS: Twenty-five randomized controlled trials (n = 1,599) were available for this meta-analysis. Significant differences in SCORAD values favoring probiotics over the control were observed overall (mean -4.51, 95% confidence interval -6.78 to -2.24), in children 1 to 18 years old (-5.74, 95% confidence interval -7.27 to -4.20), and in adults (-8.26, 95% confidence interval -13.28 to -3.25). However, the effectiveness of probiotics in infants (<1 year old) with AD was not proved. The effect of synbiotic use was not significantly different from that of probiotic use. Treatment with a mixture of different bacterial species or of Lactobacillus species showed greater benefit than did treatment with Bifidobacterium species alone. CONCLUSION: The overall result of this meta-analysis suggests that probiotics could be an option for the treatment of AD, especially for moderate to severe AD in children and adults. However, no evidence was found supporting the beneficial role of probiotics in infants. SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/24954372/Effects_of_probiotics_for_the_treatment_of_atopic_dermatitis:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(14)00370-6 DB - PRIME DP - Unbound Medicine ER -