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Effectiveness of (PhSe)2 in protect against the HgCl2 toxicity.
J Trace Elem Med Biol. 2015 Jan; 29:255-62.JT

Abstract

This work investigated the preventive effect of diphenyl diselenide [(PhSe)2] on renal and hepatic toxicity biomarkers and oxidative parameters in adult mice exposed to mercury chloride (HgCl2). Selenium (Se) and mercury (Hg) determination was also carried out. Mice received a daily oral dose of (PhSe)2 (5.0mg/kg/day) or canola oil for five consecutive days. During the following five days, the animals were treated with a daily subcutaneous dose of HgCl2 (5.0mg/kg/day) or saline (0.9%). Twenty-four hours after the last HgCl2 administration, the animals were sacrificed and biological material was obtained. Concerning toxicity biomarkers, Hg exposure inhibited blood δ-aminolevulinic acid dehydratase (δ-ALA-D), serum alanine aminotransferase (ALT) activity and also increased serum creatinine levels. (PhSe)2 partially prevented blood δ-ALA-D inhibition and totally prevented the serum creatinine increase. Regarding the oxidative parameters, Hg decreased kidney TBARS levels and increased kidney non-protein thiol levels, while (PhSe)2 pre-treatment partially protected the kidney thiol levels increase. Animals exposed to HgCl2 presented Hg content accumulation in blood, kidney and liver. The (PhSe)2 pre-treatment increased Hg accumulation in kidney and decreased in blood. These results show that (PhSe)2 can be efficient in protecting against these toxic effects presented by this Hg exposure model.

Authors+Show Affiliations

Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil; Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil; Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil. Electronic address: pereirame@yahoo.com.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24954677

Citation

Fiuza, Tiago da Luz, et al. "Effectiveness of (PhSe)2 in Protect Against the HgCl2 Toxicity." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 29, 2015, pp. 255-62.
Fiuza Tda L, Oliveira CS, da Costa M, et al. Effectiveness of (PhSe)2 in protect against the HgCl2 toxicity. J Trace Elem Med Biol. 2015;29:255-62.
Fiuza, T. d. a. . L., Oliveira, C. S., da Costa, M., Oliveira, V. A., Zeni, G., & Pereira, M. E. (2015). Effectiveness of (PhSe)2 in protect against the HgCl2 toxicity. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 29, 255-62. https://doi.org/10.1016/j.jtemb.2014.05.008
Fiuza Tda L, et al. Effectiveness of (PhSe)2 in Protect Against the HgCl2 Toxicity. J Trace Elem Med Biol. 2015;29:255-62. PubMed PMID: 24954677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of (PhSe)2 in protect against the HgCl2 toxicity. AU - Fiuza,Tiago da Luz, AU - Oliveira,Cláudia Sirlene, AU - da Costa,Michael, AU - Oliveira,Vitor Antunes, AU - Zeni,Gilson, AU - Pereira,Maria Ester, Y1 - 2014/06/04/ PY - 2014/04/04/received PY - 2014/05/19/revised PY - 2014/05/27/accepted PY - 2014/6/24/entrez PY - 2014/6/24/pubmed PY - 2015/8/6/medline KW - Diphenyl diselenide KW - Mercury KW - Se and Hg levels KW - Selenium KW - δ-Aminolevulinic acid dehydratase SP - 255 EP - 62 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 29 N2 - This work investigated the preventive effect of diphenyl diselenide [(PhSe)2] on renal and hepatic toxicity biomarkers and oxidative parameters in adult mice exposed to mercury chloride (HgCl2). Selenium (Se) and mercury (Hg) determination was also carried out. Mice received a daily oral dose of (PhSe)2 (5.0mg/kg/day) or canola oil for five consecutive days. During the following five days, the animals were treated with a daily subcutaneous dose of HgCl2 (5.0mg/kg/day) or saline (0.9%). Twenty-four hours after the last HgCl2 administration, the animals were sacrificed and biological material was obtained. Concerning toxicity biomarkers, Hg exposure inhibited blood δ-aminolevulinic acid dehydratase (δ-ALA-D), serum alanine aminotransferase (ALT) activity and also increased serum creatinine levels. (PhSe)2 partially prevented blood δ-ALA-D inhibition and totally prevented the serum creatinine increase. Regarding the oxidative parameters, Hg decreased kidney TBARS levels and increased kidney non-protein thiol levels, while (PhSe)2 pre-treatment partially protected the kidney thiol levels increase. Animals exposed to HgCl2 presented Hg content accumulation in blood, kidney and liver. The (PhSe)2 pre-treatment increased Hg accumulation in kidney and decreased in blood. These results show that (PhSe)2 can be efficient in protecting against these toxic effects presented by this Hg exposure model. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/24954677/Effectiveness_of__PhSe_2_in_protect_against_the_HgCl2_toxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(14)00074-1 DB - PRIME DP - Unbound Medicine ER -