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Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies.

Abstract

BACKGROUND

There is conflicting evidence about the association between low vitamin D levels in children and development of asthma in later life. The objective of this study was to systematically review the evidence for an epidemiological association between low serum levels of vitamin D and the diagnosis of asthma in children.

METHODS

We used the Cochrane methodology for conducting systematic reviews. The search strategy included an electronic search of MEDLINE and EMBASE in February 2013. Two reviewers completed, in duplicate and independently, study selection, data abstraction, and assessment of risk of bias.

RESULTS

Of 1081 identified citations, three cohort studies met eligibility criteria. Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels. All three studies suffer from major methodological shortcomings that limit our confidence in their results.

CONCLUSIONS

Available epidemiological evidence suggests a potential association between low serum levels of vitamin D and the diagnosis of asthma in children. High quality studies are needed to reliably answer the question of interest.

Authors+Show Affiliations

Clinical Research Institute, American University of Beirut, Beirut, Lebanon.Clinical Research Institute, American University of Beirut, Beirut, Lebanon.Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.Department of Internal Medicine, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut, Beirut, Lebanon.Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.Clinical Research Institute, American University of Beirut, Beirut, Lebanon ; Department of Internal Medicine, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut, Beirut, Lebanon ; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada ; Department of Medicine, State University of New York at Buffalo, Buffalo, New York, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24955097

Citation

Rajabbik, Mhd Hashem, et al. "Association Between Low Vitamin D Levels and the Diagnosis of Asthma in Children: a Systematic Review of Cohort Studies." Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, vol. 10, no. 1, 2014, p. 31.
Rajabbik MH, Lotfi T, Alkhaled L, et al. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy Asthma Clin Immunol. 2014;10(1):31.
Rajabbik, M. H., Lotfi, T., Alkhaled, L., Fares, M., El-Hajj Fuleihan, G., Mroueh, S., & Akl, E. A. (2014). Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 10(1), p. 31. doi:10.1186/1710-1492-10-31.
Rajabbik MH, et al. Association Between Low Vitamin D Levels and the Diagnosis of Asthma in Children: a Systematic Review of Cohort Studies. Allergy Asthma Clin Immunol. 2014;10(1):31. PubMed PMID: 24955097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. AU - Rajabbik,Mhd Hashem, AU - Lotfi,Tamara, AU - Alkhaled,Lina, AU - Fares,Munes, AU - El-Hajj Fuleihan,Ghada, AU - Mroueh,Salman, AU - Akl,Elie A, Y1 - 2014/06/11/ PY - 2013/12/18/received PY - 2014/05/27/accepted PY - 2014/6/24/entrez PY - 2014/6/24/pubmed PY - 2014/6/24/medline KW - Asthma KW - Bronchial hyper responsiveness KW - Childhood KW - Cohort KW - Lung function tests KW - Pediatric KW - Systematic review KW - Vitamin D KW - Wheezing SP - 31 EP - 31 JF - Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology JO - Allergy Asthma Clin Immunol VL - 10 IS - 1 N2 - BACKGROUND: There is conflicting evidence about the association between low vitamin D levels in children and development of asthma in later life. The objective of this study was to systematically review the evidence for an epidemiological association between low serum levels of vitamin D and the diagnosis of asthma in children. METHODS: We used the Cochrane methodology for conducting systematic reviews. The search strategy included an electronic search of MEDLINE and EMBASE in February 2013. Two reviewers completed, in duplicate and independently, study selection, data abstraction, and assessment of risk of bias. RESULTS: Of 1081 identified citations, three cohort studies met eligibility criteria. Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels. All three studies suffer from major methodological shortcomings that limit our confidence in their results. CONCLUSIONS: Available epidemiological evidence suggests a potential association between low serum levels of vitamin D and the diagnosis of asthma in children. High quality studies are needed to reliably answer the question of interest. SN - 1710-1484 UR - https://www.unboundmedicine.com/medline/citation/24955097/Association_between_low_vitamin_D_levels_and_the_diagnosis_of_asthma_in_children:_a_systematic_review_of_cohort_studies_ L2 - https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-10-31 DB - PRIME DP - Unbound Medicine ER -