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Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome.
BMC Infect Dis 2014; 14:347BI

Abstract

BACKGROUND

Lipodystrophies are characterized by adipose tissue redistribution, insulin resistance (IR) and metabolic complications. Adipokines and hormones related to body composition may play an important role linking these alterations. Our aim was to evaluate adipocyte-derived hormones (adiponectin, leptin, resistin, TNF-α, PAI-1) and ghrelin plasma levels and their relationship with IR in HIV-infected patients according to the presence of lipodystrophy and fat redistribution.

METHODS

Anthropometric and metabolic parameters, HOMA-IR, body composition by DXA and CT, and adipokines were evaluated in 217 HIV-infected patients on cART and 74 controls. Fat mass ratio defined lipodystrophy (L-FMR) was defined as the ratio of the percentage of the trunk fat mass to the percentage of the lower limb fat mass by DXA. Patient's fat redistribution was classified into 4 different groups according the presence or absence of either clinical lipoatrophy or abdominal prominence: no lipodystrophy, isolated central fat accumulation (ICFA), isolated lipoatrophy and mixed forms (MXF). The associations between adipokines levels and anthropometric, metabolic and body composition were estimated by Spearman correlation.

RESULTS

Leptin levels were lower in patients with FMR-L and isolated lipoatrophy, and higher in those with ICFA and MXF. Positive correlations were found between leptin and body fat (total, trunk, leg, arm fat evaluated by DXA, and total, visceral (VAT), subcutaneous adipose tissue (SAT), and VAT/SAT ratio evaluated by CT) regardless of FMR-L, and with HOMA-IR only in patients with FMR-L. Adiponectin correlated negatively with VAT, and its mean levels were lower in patients with ICFA and higher in those with no lipodystrophy. Resistin was not correlated with adipose tissue but positively correlated with HOMA-IR in FMR-L patients. PAI-1 levels were higher in MXF-patients and their levels were positively correlated with VAT in those with FMR-L. Ghrelin was higher in HIV-infected patients than controls despite BMI-matching.

CONCLUSION

The overall body fat reduction in HIV lipoatrophy was associated with low leptin plasma levels, and visceral fat accumulation was mainly associated with decreased plasma levels of adiponectin.

Authors+Show Affiliations

Endocrinology Department, Hospital de São João and University of Porto Medical School, Alameda Hernâni Monteiro, 4200 Porto, Portugal. paula_freitas@sapo.pt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24958357

Citation

Freitas, Paula, et al. "Adipokines, Hormones Related to Body Composition, and Insulin Resistance in HIV Fat Redistribution Syndrome." BMC Infectious Diseases, vol. 14, 2014, p. 347.
Freitas P, Carvalho D, Santos AC, et al. Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome. BMC Infect Dis. 2014;14:347.
Freitas, P., Carvalho, D., Santos, A. C., Madureira, A. J., Martinez, E., Pereira, J., ... Medina, J. L. (2014). Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome. BMC Infectious Diseases, 14, p. 347. doi:10.1186/1471-2334-14-347.
Freitas P, et al. Adipokines, Hormones Related to Body Composition, and Insulin Resistance in HIV Fat Redistribution Syndrome. BMC Infect Dis. 2014 Jun 23;14:347. PubMed PMID: 24958357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome. AU - Freitas,Paula, AU - Carvalho,Davide, AU - Santos,Ana Cristina, AU - Madureira,António José, AU - Martinez,Esteban, AU - Pereira,Jorge, AU - Sarmento,António, AU - Medina,José Luís, Y1 - 2014/06/23/ PY - 2013/09/12/received PY - 2014/06/13/accepted PY - 2014/6/25/entrez PY - 2014/6/25/pubmed PY - 2014/11/13/medline SP - 347 EP - 347 JF - BMC infectious diseases JO - BMC Infect. Dis. VL - 14 N2 - BACKGROUND: Lipodystrophies are characterized by adipose tissue redistribution, insulin resistance (IR) and metabolic complications. Adipokines and hormones related to body composition may play an important role linking these alterations. Our aim was to evaluate adipocyte-derived hormones (adiponectin, leptin, resistin, TNF-α, PAI-1) and ghrelin plasma levels and their relationship with IR in HIV-infected patients according to the presence of lipodystrophy and fat redistribution. METHODS: Anthropometric and metabolic parameters, HOMA-IR, body composition by DXA and CT, and adipokines were evaluated in 217 HIV-infected patients on cART and 74 controls. Fat mass ratio defined lipodystrophy (L-FMR) was defined as the ratio of the percentage of the trunk fat mass to the percentage of the lower limb fat mass by DXA. Patient's fat redistribution was classified into 4 different groups according the presence or absence of either clinical lipoatrophy or abdominal prominence: no lipodystrophy, isolated central fat accumulation (ICFA), isolated lipoatrophy and mixed forms (MXF). The associations between adipokines levels and anthropometric, metabolic and body composition were estimated by Spearman correlation. RESULTS: Leptin levels were lower in patients with FMR-L and isolated lipoatrophy, and higher in those with ICFA and MXF. Positive correlations were found between leptin and body fat (total, trunk, leg, arm fat evaluated by DXA, and total, visceral (VAT), subcutaneous adipose tissue (SAT), and VAT/SAT ratio evaluated by CT) regardless of FMR-L, and with HOMA-IR only in patients with FMR-L. Adiponectin correlated negatively with VAT, and its mean levels were lower in patients with ICFA and higher in those with no lipodystrophy. Resistin was not correlated with adipose tissue but positively correlated with HOMA-IR in FMR-L patients. PAI-1 levels were higher in MXF-patients and their levels were positively correlated with VAT in those with FMR-L. Ghrelin was higher in HIV-infected patients than controls despite BMI-matching. CONCLUSION: The overall body fat reduction in HIV lipoatrophy was associated with low leptin plasma levels, and visceral fat accumulation was mainly associated with decreased plasma levels of adiponectin. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/24958357/Adipokines_hormones_related_to_body_composition_and_insulin_resistance_in_HIV_fat_redistribution_syndrome_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-14-347 DB - PRIME DP - Unbound Medicine ER -