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Effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD): a randomized placebo-controlled intervention trial.
Prostaglandins Leukot Essent Fatty Acids 2014 Jul-Aug; 91(1-2):49-60PL

Abstract

OBJECTIVE

To determine whether supplementation with the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) affects behavioral symptoms and cognitive impairments in children 6-12 years of age diagnosed with attention-deficit/hyperactivity disorder (ADHD).

STUDY DESIGN

The randomized, double-blind placebo-controlled 16 weeks trial was conducted with 95 children diagnosed with ADHD according to DSM-IV criteria. Behavior was assessed by parents, teachers and investigators using standardized rating scales and questionnaires. Further outcome variables were working memory, speed of information processing and various measures of attention. For a subgroup of 81 participants, erythrocyte membrane fatty acid composition was analyzed before and after the intervention.

RESULTS

Supplementation with the omega-3 fatty acid mix increased EPA and DHA concentrations in erythrocyte membranes and improved working memory function, but had no effect on other cognitive measures and parent- and teacher-rated behavior in the study population. Improved working memory correlated significantly with increased EPA, DHA and decreased AA (arachidonic acid).

Authors+Show Affiliations

Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany; Department of Psychiatry, University Hospital, Ulm, Germany. Electronic address: katharina.widenhorn-mueller@uni-ulm.de.SPZ, University Children׳s Hospital, Division of Social Pediatrics and Child Neurology, Ulm, Germany.Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany.Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany; Department of Psychiatry, University Hospital, Ulm, Germany.SPZ, University Children׳s Hospital, Division of Social Pediatrics and Child Neurology, Ulm, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24958525

Citation

Widenhorn-Müller, Katharina, et al. "Effect of Supplementation With Long-chain Ω-3 Polyunsaturated Fatty Acids On Behavior and Cognition in Children With Attention Deficit/hyperactivity Disorder (ADHD): a Randomized Placebo-controlled Intervention Trial." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 91, no. 1-2, 2014, pp. 49-60.
Widenhorn-Müller K, Schwanda S, Scholz E, et al. Effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD): a randomized placebo-controlled intervention trial. Prostaglandins Leukot Essent Fatty Acids. 2014;91(1-2):49-60.
Widenhorn-Müller, K., Schwanda, S., Scholz, E., Spitzer, M., & Bode, H. (2014). Effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD): a randomized placebo-controlled intervention trial. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 91(1-2), pp. 49-60. doi:10.1016/j.plefa.2014.04.004.
Widenhorn-Müller K, et al. Effect of Supplementation With Long-chain Ω-3 Polyunsaturated Fatty Acids On Behavior and Cognition in Children With Attention Deficit/hyperactivity Disorder (ADHD): a Randomized Placebo-controlled Intervention Trial. Prostaglandins Leukot Essent Fatty Acids. 2014;91(1-2):49-60. PubMed PMID: 24958525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD): a randomized placebo-controlled intervention trial. AU - Widenhorn-Müller,Katharina, AU - Schwanda,Simone, AU - Scholz,Elke, AU - Spitzer,Manfred, AU - Bode,Harald, Y1 - 2014/05/28/ PY - 2013/08/15/received PY - 2014/04/17/revised PY - 2014/04/26/accepted PY - 2014/6/25/entrez PY - 2014/6/25/pubmed PY - 2015/2/24/medline KW - Attention deficit/hyperactivity disorder (ADHD) KW - Behavior KW - Children KW - Intervention KW - Polyunsaturated fatty acids/erythrocyte membrane composition KW - Working memory SP - 49 EP - 60 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 91 IS - 1-2 N2 - OBJECTIVE: To determine whether supplementation with the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) affects behavioral symptoms and cognitive impairments in children 6-12 years of age diagnosed with attention-deficit/hyperactivity disorder (ADHD). STUDY DESIGN: The randomized, double-blind placebo-controlled 16 weeks trial was conducted with 95 children diagnosed with ADHD according to DSM-IV criteria. Behavior was assessed by parents, teachers and investigators using standardized rating scales and questionnaires. Further outcome variables were working memory, speed of information processing and various measures of attention. For a subgroup of 81 participants, erythrocyte membrane fatty acid composition was analyzed before and after the intervention. RESULTS: Supplementation with the omega-3 fatty acid mix increased EPA and DHA concentrations in erythrocyte membranes and improved working memory function, but had no effect on other cognitive measures and parent- and teacher-rated behavior in the study population. Improved working memory correlated significantly with increased EPA, DHA and decreased AA (arachidonic acid). SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/24958525/Effect_of_supplementation_with_long_chain_ω_3_polyunsaturated_fatty_acids_on_behavior_and_cognition_in_children_with_attention_deficit/hyperactivity_disorder__ADHD_:_a_randomized_placebo_controlled_intervention_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(14)00076-3 DB - PRIME DP - Unbound Medicine ER -