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The median effective dose of dexmedetomidine for laryngeal mask airway insertion with propofol 2.0 mg/kg.
Acta Anaesthesiol Scand. 2014 Aug; 58(7):815-9.AA

Abstract

BACKGROUND

Dexmedetomidine can be used as a co-induction agent to facilitate laryngeal mask airway (LMA) insertion with minimal effect on respiratory function. The purpose of the study was to determine the median effective dose (ED50) of dexmedetomidine to facilitate LMA insertion during anaesthesia induction with propofol 2.0 mg/kg without neuromuscular blockade.

METHODS

Twenty-two patients, whose American Society of Anesthesiologists physical status was I or II with ages between 18 and 60 years undergoing minor orthopaedic or gynaecological surgery, were enrolled. After an injection of pre-determined bolus dose of dexmedetomidine over 2 min, anaesthesia was induced with propofol 2.0 mg/kg. The modified Dixon's up-and-down method was used to determine the bolus dose of dexmedetomidine, starting from 0.5 μg/kg (step size; 0.1 μg/kg). LMA insertion was conducted 90 s after the propofol injection, and the response of patients was categorized as either 'success' or 'failure.'

RESULTS

Insertion of the LMA was unsuccessful in 12 of 22 patients. The ED50 (95% confidence interval) of dexmedetomidine for successful LMA insertion with propofol 2.0 mg/kg was 0.55 (0.44-0.66) μg/kg. Bradycardia occurred in four patients, and seven patients had an apneic episode.

CONCLUSION

The single dose of dexmedetomidine for successful LMA insertion to be feasible in 50% of patients was 0.55 μg/kg during anaesthesia induction with propofol 2 mg/kg.

Authors+Show Affiliations

Department of Anaesthesiology and Pain Medicine, Gil Medical Center, Gachon University, Incheon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

24961283

Citation

Kwak, H J., et al. "The Median Effective Dose of Dexmedetomidine for Laryngeal Mask Airway Insertion With Propofol 2.0 Mg/kg." Acta Anaesthesiologica Scandinavica, vol. 58, no. 7, 2014, pp. 815-9.
Kwak HJ, Min SK, Yoo JY, et al. The median effective dose of dexmedetomidine for laryngeal mask airway insertion with propofol 2.0 mg/kg. Acta Anaesthesiol Scand. 2014;58(7):815-9.
Kwak, H. J., Min, S. K., Yoo, J. Y., Park, K. H., & Kim, J. Y. (2014). The median effective dose of dexmedetomidine for laryngeal mask airway insertion with propofol 2.0 mg/kg. Acta Anaesthesiologica Scandinavica, 58(7), 815-9. https://doi.org/10.1111/aas.12338
Kwak HJ, et al. The Median Effective Dose of Dexmedetomidine for Laryngeal Mask Airway Insertion With Propofol 2.0 Mg/kg. Acta Anaesthesiol Scand. 2014;58(7):815-9. PubMed PMID: 24961283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The median effective dose of dexmedetomidine for laryngeal mask airway insertion with propofol 2.0 mg/kg. AU - Kwak,H J, AU - Min,S K, AU - Yoo,J Y, AU - Park,K H, AU - Kim,J Y, Y1 - 2014/06/24/ PY - 2014/04/11/accepted PY - 2014/6/26/entrez PY - 2014/6/26/pubmed PY - 2015/3/31/medline SP - 815 EP - 9 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 58 IS - 7 N2 - BACKGROUND: Dexmedetomidine can be used as a co-induction agent to facilitate laryngeal mask airway (LMA) insertion with minimal effect on respiratory function. The purpose of the study was to determine the median effective dose (ED50) of dexmedetomidine to facilitate LMA insertion during anaesthesia induction with propofol 2.0 mg/kg without neuromuscular blockade. METHODS: Twenty-two patients, whose American Society of Anesthesiologists physical status was I or II with ages between 18 and 60 years undergoing minor orthopaedic or gynaecological surgery, were enrolled. After an injection of pre-determined bolus dose of dexmedetomidine over 2 min, anaesthesia was induced with propofol 2.0 mg/kg. The modified Dixon's up-and-down method was used to determine the bolus dose of dexmedetomidine, starting from 0.5 μg/kg (step size; 0.1 μg/kg). LMA insertion was conducted 90 s after the propofol injection, and the response of patients was categorized as either 'success' or 'failure.' RESULTS: Insertion of the LMA was unsuccessful in 12 of 22 patients. The ED50 (95% confidence interval) of dexmedetomidine for successful LMA insertion with propofol 2.0 mg/kg was 0.55 (0.44-0.66) μg/kg. Bradycardia occurred in four patients, and seven patients had an apneic episode. CONCLUSION: The single dose of dexmedetomidine for successful LMA insertion to be feasible in 50% of patients was 0.55 μg/kg during anaesthesia induction with propofol 2 mg/kg. SN - 1399-6576 UR - https://www.unboundmedicine.com/medline/citation/24961283/The_median_effective_dose_of_dexmedetomidine_for_laryngeal_mask_airway_insertion_with_propofol_2_0_mg/kg_ L2 - https://doi.org/10.1111/aas.12338 DB - PRIME DP - Unbound Medicine ER -