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Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III.
Eur J Clin Nutr. 2014 Sep; 68(9):1001-7.EJ

Abstract

BACKGROUND

Sarcopenia is defined as the loss of skeletal muscle mass and quality, which accelerates with aging and is associated with functional decline. Rising obesity prevalence has led to a high-risk group with both disorders. We assessed mortality risk associated with sarcopenia and sarcopenic obesity in elders.

METHODS

A subsample of 4652 subjects ≥60 years of age was identified from the National Health and Nutrition Examination Survey III (1988-1994), a cross-sectional survey of non-institutionalized adults. National Death Index data were linked to this data set. Sarcopenia was defined using a bioelectrical impedance formula validated using magnetic resonance imaging-measured skeletal mass by Janssen et al. Cutoffs for total skeletal muscle mass adjusted for height(2) were sex-specific (men: ≤5.75 kg/m(2); females ≤10.75 kg/m(2)). Obesity was based on % body fat (males: ≥27%, females: ≥38%). Modeling assessed mortality adjusting for age, sex, ethnicity (model 1), comorbidities (hypertension, diabetes, congestive heart failure, osteoporosis, cancer, coronary artery disease and arthritis), smoking, physical activity, self-reported health (model 2) and mobility limitations (model 3).

RESULTS

Mean age was 70.6±0.2 years and 57.2% were female. Median follow-up was 14.3 years (interquartile range: 12.5-16.1). Overall prevalence of sarcopenia was 35.4% in women and 75.5% in men, which increased with age. Prevalence of obesity was 60.8% in women and 54.4% in men. Sarcopenic obesity prevalence was 18.1% in women and 42.9% in men. There were 2782 (61.7%) deaths, of which 39.0% were cardiovascular. Women with sarcopenia and sarcopenic obesity had a higher mortality risk than those without sarcopenia or obesity after adjustment (model 2, hazard ratio (HR): 1.35 (1.05-1.74) and 1.29 (1.03-1.60)). After adjusting for mobility limitations (model 3), sarcopenia alone (HR: 1.32 ((1.04-1.69) but not sarcopenia with obesity (HR: 1.25 (0.99-1.58)) was associated with mortality. For men, the risk of death with sarcopenia and sarcopenic obesity was nonsignificant in both model-2 (HR: 0.98 (0.77-1.25), and HR: 0.99 (0.79-1.23)) and model 3 (HR: 0.98 (0.77-1.24) and HR: 0.98 (0.79-1.22)).

CONCLUSIONS

Older women with sarcopenia have an increased all-cause mortality risk independent of obesity.

Authors+Show Affiliations

1] Section of General Internal Medicine, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA [2] Geisel School of Medicine at Dartmouth, Hanover, NH, USA [3] Centers for Aging and Aging Research, Dartmouth College, Hanover, NH, USA.Geisel School of Medicine at Dartmouth, Hanover, NH, USA.1] Geisel School of Medicine at Dartmouth, Hanover, NH, USA [2] Centers for Aging and Aging Research, Dartmouth College, Hanover, NH, USA.Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.1] Geisel School of Medicine at Dartmouth, Hanover, NH, USA [2] Centers for Aging and Aging Research, Dartmouth College, Hanover, NH, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24961545

Citation

Batsis, J A., et al. "Sarcopenia, Sarcopenic Obesity and Mortality in Older Adults: Results From the National Health and Nutrition Examination Survey III." European Journal of Clinical Nutrition, vol. 68, no. 9, 2014, pp. 1001-7.
Batsis JA, Mackenzie TA, Barre LK, et al. Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III. Eur J Clin Nutr. 2014;68(9):1001-7.
Batsis, J. A., Mackenzie, T. A., Barre, L. K., Lopez-Jimenez, F., & Bartels, S. J. (2014). Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III. European Journal of Clinical Nutrition, 68(9), 1001-7. https://doi.org/10.1038/ejcn.2014.117
Batsis JA, et al. Sarcopenia, Sarcopenic Obesity and Mortality in Older Adults: Results From the National Health and Nutrition Examination Survey III. Eur J Clin Nutr. 2014;68(9):1001-7. PubMed PMID: 24961545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III. AU - Batsis,J A, AU - Mackenzie,T A, AU - Barre,L K, AU - Lopez-Jimenez,F, AU - Bartels,S J, Y1 - 2014/06/25/ PY - 2013/09/28/received PY - 2014/04/28/revised PY - 2014/05/15/accepted PY - 2014/6/26/entrez PY - 2014/6/26/pubmed PY - 2015/5/12/medline SP - 1001 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 68 IS - 9 N2 - BACKGROUND: Sarcopenia is defined as the loss of skeletal muscle mass and quality, which accelerates with aging and is associated with functional decline. Rising obesity prevalence has led to a high-risk group with both disorders. We assessed mortality risk associated with sarcopenia and sarcopenic obesity in elders. METHODS: A subsample of 4652 subjects ≥60 years of age was identified from the National Health and Nutrition Examination Survey III (1988-1994), a cross-sectional survey of non-institutionalized adults. National Death Index data were linked to this data set. Sarcopenia was defined using a bioelectrical impedance formula validated using magnetic resonance imaging-measured skeletal mass by Janssen et al. Cutoffs for total skeletal muscle mass adjusted for height(2) were sex-specific (men: ≤5.75 kg/m(2); females ≤10.75 kg/m(2)). Obesity was based on % body fat (males: ≥27%, females: ≥38%). Modeling assessed mortality adjusting for age, sex, ethnicity (model 1), comorbidities (hypertension, diabetes, congestive heart failure, osteoporosis, cancer, coronary artery disease and arthritis), smoking, physical activity, self-reported health (model 2) and mobility limitations (model 3). RESULTS: Mean age was 70.6±0.2 years and 57.2% were female. Median follow-up was 14.3 years (interquartile range: 12.5-16.1). Overall prevalence of sarcopenia was 35.4% in women and 75.5% in men, which increased with age. Prevalence of obesity was 60.8% in women and 54.4% in men. Sarcopenic obesity prevalence was 18.1% in women and 42.9% in men. There were 2782 (61.7%) deaths, of which 39.0% were cardiovascular. Women with sarcopenia and sarcopenic obesity had a higher mortality risk than those without sarcopenia or obesity after adjustment (model 2, hazard ratio (HR): 1.35 (1.05-1.74) and 1.29 (1.03-1.60)). After adjusting for mobility limitations (model 3), sarcopenia alone (HR: 1.32 ((1.04-1.69) but not sarcopenia with obesity (HR: 1.25 (0.99-1.58)) was associated with mortality. For men, the risk of death with sarcopenia and sarcopenic obesity was nonsignificant in both model-2 (HR: 0.98 (0.77-1.25), and HR: 0.99 (0.79-1.23)) and model 3 (HR: 0.98 (0.77-1.24) and HR: 0.98 (0.79-1.22)). CONCLUSIONS: Older women with sarcopenia have an increased all-cause mortality risk independent of obesity. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/24961545/Sarcopenia_sarcopenic_obesity_and_mortality_in_older_adults:_results_from_the_National_Health_and_Nutrition_Examination_Survey_III_ L2 - http://dx.doi.org/10.1038/ejcn.2014.117 DB - PRIME DP - Unbound Medicine ER -