Tags

Type your tag names separated by a space and hit enter

Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease.
Biomed Environ Sci. 2014 Jun; 27(6):462-5.BE

Abstract

Parkinson's disease (PD) is a typical degenerative disease, which is characterized by the most obvious symptoms of movement dysfunction, including shaking, rigidity, slowness of movement and difficulty in walking and gait. This disease can not be clearly identified through laboratory tests at present, thus application of high-throughput technique in studying the expression profiles of PD helps to find the genetic markers for its early diagnosis. Studies on expression profiles of neurodegenerative diseases have revealed the novel genes and pathways involved in the progress of illness. In this study, the expression profiles of PD in blood were compared, showing that 181 differentially expressed genes (DEG) exhibit a similar expression trend both in patients and in normal controls. These genes are enriched significantly in some biological processes, including development, response to drugs, and DNA-dependent regulation of transcription, etc, highlighting that the genetic markers can be used in early diagnosis of PD.

Authors+Show Affiliations

Cell Engineering Research Center, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China.Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi, China.The School of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.Department of laboratory medicine, Beijing Jishuitan Hospital, Beijing 100035, China.State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Hangzhou, China, 310003), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.The School of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.Network Information Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24961856

Citation

Zhang, Yi, et al. "Bioinformatics Analysis Raises Candidate Genes in Blood for Early Screening of Parkinson's Disease." Biomedical and Environmental Sciences : BES, vol. 27, no. 6, 2014, pp. 462-5.
Zhang Y, Yao L, Liu W, et al. Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease. Biomed Environ Sci. 2014;27(6):462-5.
Zhang, Y., Yao, L., Liu, W., Li, W., Tian, C., Wang, Z. Y., & Liu, D. (2014). Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease. Biomedical and Environmental Sciences : BES, 27(6), 462-5. https://doi.org/10.3967/bes2014.074
Zhang Y, et al. Bioinformatics Analysis Raises Candidate Genes in Blood for Early Screening of Parkinson's Disease. Biomed Environ Sci. 2014;27(6):462-5. PubMed PMID: 24961856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease. AU - Zhang,Yi, AU - Yao,Li, AU - Liu,Wei, AU - Li,Wei, AU - Tian,Chan, AU - Wang,Zhao Yang, AU - Liu,Di, PY - 2014/05/04/received PY - 2014/05/29/accepted PY - 2014/6/26/entrez PY - 2014/6/26/pubmed PY - 2014/9/12/medline SP - 462 EP - 5 JF - Biomedical and environmental sciences : BES JO - Biomed Environ Sci VL - 27 IS - 6 N2 - Parkinson's disease (PD) is a typical degenerative disease, which is characterized by the most obvious symptoms of movement dysfunction, including shaking, rigidity, slowness of movement and difficulty in walking and gait. This disease can not be clearly identified through laboratory tests at present, thus application of high-throughput technique in studying the expression profiles of PD helps to find the genetic markers for its early diagnosis. Studies on expression profiles of neurodegenerative diseases have revealed the novel genes and pathways involved in the progress of illness. In this study, the expression profiles of PD in blood were compared, showing that 181 differentially expressed genes (DEG) exhibit a similar expression trend both in patients and in normal controls. These genes are enriched significantly in some biological processes, including development, response to drugs, and DNA-dependent regulation of transcription, etc, highlighting that the genetic markers can be used in early diagnosis of PD. SN - 0895-3988 UR - https://www.unboundmedicine.com/medline/citation/24961856/Bioinformatics_analysis_raises_candidate_genes_in_blood_for_early_screening_of_Parkinson's_disease_ L2 - https://doi.org/10.3967/bes2014.074 DB - PRIME DP - Unbound Medicine ER -