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Influence of phytase, EDTA, and polyphenols on zinc absorption in adults from porridges fortified with zinc sulfate or zinc oxide.
J Nutr. 2014 Sep; 144(9):1467-73.JN

Abstract

Fortification of cereal staples with zinc is recommended to combat zinc deficiency. To optimize zinc absorption, strategies are needed to overcome the inhibitory effect of phytic acid (PA) and perhaps polyphenols. Five zinc absorption studies were conducted in young adults consuming maize or sorghum porridges fortified with 2 mg zinc as zinc sulfate (ZnSO4) or zinc oxide (ZnO) and containing combinations of PA or polyphenols as potential inhibitors and EDTA and phytase as potential enhancers. Fractional absorption of zinc (FAZ) was measured by using the double isotopic tracer ratio method. Adding phytase to the maize porridge immediately before consumption or using phytase for dephytinization during meal preparation both increased FAZ by >80% (both P < 0.001). Adding Na2EDTA at an EDTA:zinc molar ratio of 1:1 increased FAZ from maize porridge fortified with ZnSO4 by 30% (P = 0.01) but had no influence at higher EDTA ratios or on absorption from ZnO. FAZ was slightly higher from ZnSO4 than from ZnO (P = 0.02). Sorghum polyphenols had no effect on FAZ from dephytinized sorghum porridges but decreased FAZ by 20% from PA-rich sorghum porridges (P < 0.02). The combined inhibitory effect of polyphenols and PA was overcome by EDTA. In conclusion, ZnSO4 was better absorbed than ZnO, phytase used to degrade PA during digestion or during food preparation substantially increased zinc absorption from zinc-fortified cereals, EDTA at a 1:1 molar ratio modestly enhanced zinc absorption from ZnSO4-fortified cereals but not ZnO-fortified cereals, and sorghum polyphenols inhibited zinc absorption in the presence, but not absence, of PA. This trial was registered at clinicaltrials.gov as NCT01210794.

Authors+Show Affiliations

Laboratory of Human Nutrition, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland; and marica@sunrise.ch.Laboratory of Human Nutrition, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland; and.Laboratory of Human Nutrition, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland; and.Clinical Trials Center, University and University Hospital Zurich, Zurich, Switzerland.Laboratory of Human Nutrition, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland; and.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24966411

Citation

Brnić, Marica, et al. "Influence of Phytase, EDTA, and Polyphenols On Zinc Absorption in Adults From Porridges Fortified With Zinc Sulfate or Zinc Oxide." The Journal of Nutrition, vol. 144, no. 9, 2014, pp. 1467-73.
Brnić M, Wegmüller R, Zeder C, et al. Influence of phytase, EDTA, and polyphenols on zinc absorption in adults from porridges fortified with zinc sulfate or zinc oxide. J Nutr. 2014;144(9):1467-73.
Brnić, M., Wegmüller, R., Zeder, C., Senti, G., & Hurrell, R. F. (2014). Influence of phytase, EDTA, and polyphenols on zinc absorption in adults from porridges fortified with zinc sulfate or zinc oxide. The Journal of Nutrition, 144(9), 1467-73. https://doi.org/10.3945/jn.113.185322
Brnić M, et al. Influence of Phytase, EDTA, and Polyphenols On Zinc Absorption in Adults From Porridges Fortified With Zinc Sulfate or Zinc Oxide. J Nutr. 2014;144(9):1467-73. PubMed PMID: 24966411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of phytase, EDTA, and polyphenols on zinc absorption in adults from porridges fortified with zinc sulfate or zinc oxide. AU - Brnić,Marica, AU - Wegmüller,Rita, AU - Zeder,Christophe, AU - Senti,Gabriela, AU - Hurrell,Richard F, Y1 - 2014/06/25/ PY - 2014/6/27/entrez PY - 2014/6/27/pubmed PY - 2014/12/17/medline SP - 1467 EP - 73 JF - The Journal of nutrition JO - J Nutr VL - 144 IS - 9 N2 - Fortification of cereal staples with zinc is recommended to combat zinc deficiency. To optimize zinc absorption, strategies are needed to overcome the inhibitory effect of phytic acid (PA) and perhaps polyphenols. Five zinc absorption studies were conducted in young adults consuming maize or sorghum porridges fortified with 2 mg zinc as zinc sulfate (ZnSO4) or zinc oxide (ZnO) and containing combinations of PA or polyphenols as potential inhibitors and EDTA and phytase as potential enhancers. Fractional absorption of zinc (FAZ) was measured by using the double isotopic tracer ratio method. Adding phytase to the maize porridge immediately before consumption or using phytase for dephytinization during meal preparation both increased FAZ by >80% (both P < 0.001). Adding Na2EDTA at an EDTA:zinc molar ratio of 1:1 increased FAZ from maize porridge fortified with ZnSO4 by 30% (P = 0.01) but had no influence at higher EDTA ratios or on absorption from ZnO. FAZ was slightly higher from ZnSO4 than from ZnO (P = 0.02). Sorghum polyphenols had no effect on FAZ from dephytinized sorghum porridges but decreased FAZ by 20% from PA-rich sorghum porridges (P < 0.02). The combined inhibitory effect of polyphenols and PA was overcome by EDTA. In conclusion, ZnSO4 was better absorbed than ZnO, phytase used to degrade PA during digestion or during food preparation substantially increased zinc absorption from zinc-fortified cereals, EDTA at a 1:1 molar ratio modestly enhanced zinc absorption from ZnSO4-fortified cereals but not ZnO-fortified cereals, and sorghum polyphenols inhibited zinc absorption in the presence, but not absence, of PA. This trial was registered at clinicaltrials.gov as NCT01210794. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/24966411/Influence_of_phytase_EDTA_and_polyphenols_on_zinc_absorption_in_adults_from_porridges_fortified_with_zinc_sulfate_or_zinc_oxide_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.113.185322 DB - PRIME DP - Unbound Medicine ER -