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Cronkhite-Canada syndrome: report of six cases and review of literature.
World J Gastroenterol. 2014 Jun 21; 20(23):7518-22.WJ

Abstract

Cronkhite-Canada syndrome (CCS) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances in the gastrointestinal tract and skin. The aim of this study was to investigate the clinical features and potential therapies for CCS. Six patients with CCS admitted from December 1992 to July 2008 to Peking Union Medical College Hospital were evaluated. All patients had clinical manifestation of nonhereditary gastrointestinal polyposis with diarrhea, skin hyperpigmentation, alopecia, and nail dystrophy. Fecal occult blood was positive in all six cases. Serum hemoglobin, potassium, calcium and protein were below the normal range in two cases. Anti-Saccharomyces cerevisiae and antinuclear antibodies were present in three cases. Multiple polyps were found in all patients by gastroscopy and colonoscopy, with only one in the esophagus. Histologically, there were hyperplastic polyps in five cases, tubular adenoma in three, and juvenile polyp in one with chronic inflammation and mucosal edema. Comprehensive treatment led by corticosteroids can result in partial remission of clinical symptoms, and long-term follow-up is necessary.

Authors+Show Affiliations

Xiao-Heng Wen, Lan Wang, Jia-Ming Qian, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.Xiao-Heng Wen, Lan Wang, Jia-Ming Qian, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.Xiao-Heng Wen, Lan Wang, Jia-Ming Qian, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.Xiao-Heng Wen, Lan Wang, Jia-Ming Qian, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

24966624

Citation

Wen, Xiao-Heng, et al. "Cronkhite-Canada Syndrome: Report of Six Cases and Review of Literature." World Journal of Gastroenterology, vol. 20, no. 23, 2014, pp. 7518-22.
Wen XH, Wang L, Wang YX, et al. Cronkhite-Canada syndrome: report of six cases and review of literature. World J Gastroenterol. 2014;20(23):7518-22.
Wen, X. H., Wang, L., Wang, Y. X., & Qian, J. M. (2014). Cronkhite-Canada syndrome: report of six cases and review of literature. World Journal of Gastroenterology, 20(23), 7518-22. https://doi.org/10.3748/wjg.v20.i23.7518
Wen XH, et al. Cronkhite-Canada Syndrome: Report of Six Cases and Review of Literature. World J Gastroenterol. 2014 Jun 21;20(23):7518-22. PubMed PMID: 24966624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cronkhite-Canada syndrome: report of six cases and review of literature. AU - Wen,Xiao-Heng, AU - Wang,Lan, AU - Wang,Yu-Xuan, AU - Qian,Jia-Ming, PY - 2014/01/14/received PY - 2014/02/22/revised PY - 2014/04/08/accepted PY - 2014/6/27/entrez PY - 2014/6/27/pubmed PY - 2015/4/14/medline KW - Clinical feature KW - Cronkhite-Canada syndrome KW - Etiology KW - Therapeutics SP - 7518 EP - 22 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 23 N2 - Cronkhite-Canada syndrome (CCS) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances in the gastrointestinal tract and skin. The aim of this study was to investigate the clinical features and potential therapies for CCS. Six patients with CCS admitted from December 1992 to July 2008 to Peking Union Medical College Hospital were evaluated. All patients had clinical manifestation of nonhereditary gastrointestinal polyposis with diarrhea, skin hyperpigmentation, alopecia, and nail dystrophy. Fecal occult blood was positive in all six cases. Serum hemoglobin, potassium, calcium and protein were below the normal range in two cases. Anti-Saccharomyces cerevisiae and antinuclear antibodies were present in three cases. Multiple polyps were found in all patients by gastroscopy and colonoscopy, with only one in the esophagus. Histologically, there were hyperplastic polyps in five cases, tubular adenoma in three, and juvenile polyp in one with chronic inflammation and mucosal edema. Comprehensive treatment led by corticosteroids can result in partial remission of clinical symptoms, and long-term follow-up is necessary. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24966624/Cronkhite_Canada_syndrome:_report_of_six_cases_and_review_of_literature_ L2 - http://www.wjgnet.com/1007-9327/full/v20/i23/7518.htm DB - PRIME DP - Unbound Medicine ER -