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[Preparation and characterization of genipin-crosslinked silk fibroin/chitosan controlled-release microspheres].
Nan Fang Yi Ke Da Xue Xue Bao 2014; 34(6):875-9NF

Abstract

OBJECTIVE

To investigate the property of genipin-crosslinked silk fibroin(SF)/chitosan(CS) microspheres for slow releasing of bovine serum albumin (BSA).

METHODS

BSA-loaded genipin-crosslinked SF/CS microspheres were prepared by emulsion cross-linking technique. The micropheres were observed for surface morphology and size distribution under scanning electron microscope (SEM), and X-ray diffractometry (XRD) and fourier transform infrared spectroscopy (FTIR) were used to analyze their structural characteristics. BCA method was used for determining the drug entrapment, loading rate and cumulative drug release in 21 days.

RESULT

The microspheres were spherical and showed a smooth surface with an average diameter of 7.84∓0.97 µm. The drug entrapment efficiency of the microspheres was (50.16∓4.32)% with a drug loading ratio of (1.25∓0.11)% and a cumulative release of the total drug of (75.2∓2.53)% in 21 days.

CONCLUSION

Genipin-crosslinked SF/CS microspheres have a high drug entrapment efficiency and possess good capacity of sustained drug release.

Authors+Show Affiliations

Ye M
Guangdong Provincial Stomatological Hospital Affiliated to Southern Medical University, Guangzhou 510220, China.E-mail: spiritsealove@126.com.
Zeng S
No affiliation info available
Gao W
No affiliation info available
Rong M
No affiliation info available
Guo Z
No affiliation info available
Shi Y
No affiliation info available
Gan H
No affiliation info available

MeSH

ChitosanDelayed-Action PreparationsEmulsionsFibroinsIridoidsMicroscopy, Electron, ScanningMicrospheresParticle SizeSpectroscopy, Fourier Transform InfraredX-Ray DiffractionX-Rays

Pub Type(s)

Journal Article

Language

chi

PubMed ID

24968848

Citation

Ye, Manwen, et al. "[Preparation and Characterization of Genipin-crosslinked Silk Fibroin/chitosan Controlled-release Microspheres]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 34, no. 6, 2014, pp. 875-9.
Ye M, Zeng S, Gao W, et al. [Preparation and characterization of genipin-crosslinked silk fibroin/chitosan controlled-release microspheres]. Nan Fang Yi Ke Da Xue Xue Bao. 2014;34(6):875-9.
Ye, M., Zeng, S., Gao, W., Rong, M., Guo, Z., Shi, Y., & Gan, H. (2014). [Preparation and characterization of genipin-crosslinked silk fibroin/chitosan controlled-release microspheres]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 34(6), pp. 875-9.
Ye M, et al. [Preparation and Characterization of Genipin-crosslinked Silk Fibroin/chitosan Controlled-release Microspheres]. Nan Fang Yi Ke Da Xue Xue Bao. 2014;34(6):875-9. PubMed PMID: 24968848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Preparation and characterization of genipin-crosslinked silk fibroin/chitosan controlled-release microspheres]. AU - Ye,Manwen, AU - Zeng,Shuguang, AU - Gao,Wenfeng, AU - Rong,Mingdeng, AU - Guo,Zehong, AU - Shi,Yong, AU - Gan,Huiyong, PY - 2014/6/28/entrez PY - 2014/6/28/pubmed PY - 2015/9/12/medline SP - 875 EP - 9 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 34 IS - 6 N2 - OBJECTIVE: To investigate the property of genipin-crosslinked silk fibroin(SF)/chitosan(CS) microspheres for slow releasing of bovine serum albumin (BSA). METHODS: BSA-loaded genipin-crosslinked SF/CS microspheres were prepared by emulsion cross-linking technique. The micropheres were observed for surface morphology and size distribution under scanning electron microscope (SEM), and X-ray diffractometry (XRD) and fourier transform infrared spectroscopy (FTIR) were used to analyze their structural characteristics. BCA method was used for determining the drug entrapment, loading rate and cumulative drug release in 21 days. RESULT: The microspheres were spherical and showed a smooth surface with an average diameter of 7.84∓0.97 µm. The drug entrapment efficiency of the microspheres was (50.16∓4.32)% with a drug loading ratio of (1.25∓0.11)% and a cumulative release of the total drug of (75.2∓2.53)% in 21 days. CONCLUSION: Genipin-crosslinked SF/CS microspheres have a high drug entrapment efficiency and possess good capacity of sustained drug release. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/24968848/[Preparation_and_characterization_of_genipin_crosslinked_silk_fibroin/chitosan_controlled_release_microspheres]_ DB - PRIME DP - Unbound Medicine ER -