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Modulating the microbiota in inflammatory bowel diseases: prebiotics, probiotics or faecal transplantation?
Proc Nutr Soc 2014; 73(4):490-7PN

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are the two major phenotypes of inflammatory bowel diseases (IBD) which constitute a spectrum of chronic, debilitating diseases characterised by a relapsing inflammation of the intestinal mucosal lining. Evidence from a variety of disciplines implicates the intestinal microbiota in the pathogenesis of idiopathic IBD and their complications, including pouchitis. Many studies have reported a dysbiosis in IBD, characterised by a decrease in diversity, a decreased abundance of some dominant commensal members (such as Clostridium IV and XIVa) and an increase in detrimental bacteria (such as sulphate reducing bacteria and Escherichia coli). Therapies such as prebiotics and probiotics aim to selectively manipulate the intestinal microbiota and have been evaluated as an attractive therapeutic option with few side effects. The multispecies product VSL#3 was found effective in preventing and maintaining remission in pouchitis, whereas both VSL#3 and E. coli Nissle were effective in maintaining remission in UC. A more drastic approach to restore the composition of the microbiota and correct the underlying imbalance is a faecal microbiota transplantation (FMT). FMT has been successfully applied to treat patients with even recalcitrant Clostridium difficile infection. Particularly in UC, the majority of studies suggest that FMT may be an effective treatment option although the evidence is still limited. It is anticipated that our increasing knowledge on the composition and function of the intestinal microbiota components will allow in the future for a better selection of highly performing bacteria with specific functions required for specific benefits.

Authors+Show Affiliations

KU Leuven,Translational Research in Gastrointestinal Disorders,Herestraat 49, O&N1, box 701 B - 3000 Leuven,Belgium.KU Leuven,Translational Research in Gastrointestinal Disorders,Herestraat 49, O&N1, box 701 B - 3000 Leuven,Belgium.KU Leuven,Translational Research in Gastrointestinal Disorders,Herestraat 49, O&N1, box 701 B - 3000 Leuven,Belgium.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24969143

Citation

Verbeke, Kristin A., et al. "Modulating the Microbiota in Inflammatory Bowel Diseases: Prebiotics, Probiotics or Faecal Transplantation?" The Proceedings of the Nutrition Society, vol. 73, no. 4, 2014, pp. 490-7.
Verbeke KA, Boesmans L, Boets E. Modulating the microbiota in inflammatory bowel diseases: prebiotics, probiotics or faecal transplantation? Proc Nutr Soc. 2014;73(4):490-7.
Verbeke, K. A., Boesmans, L., & Boets, E. (2014). Modulating the microbiota in inflammatory bowel diseases: prebiotics, probiotics or faecal transplantation? The Proceedings of the Nutrition Society, 73(4), pp. 490-7. doi:10.1017/S0029665114000639.
Verbeke KA, Boesmans L, Boets E. Modulating the Microbiota in Inflammatory Bowel Diseases: Prebiotics, Probiotics or Faecal Transplantation. Proc Nutr Soc. 2014;73(4):490-7. PubMed PMID: 24969143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulating the microbiota in inflammatory bowel diseases: prebiotics, probiotics or faecal transplantation? AU - Verbeke,Kristin A, AU - Boesmans,Leen, AU - Boets,Eef, Y1 - 2014/06/27/ PY - 2014/6/28/entrez PY - 2014/6/28/pubmed PY - 2015/6/17/medline SP - 490 EP - 7 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 73 IS - 4 N2 - Crohn's disease (CD) and ulcerative colitis (UC) are the two major phenotypes of inflammatory bowel diseases (IBD) which constitute a spectrum of chronic, debilitating diseases characterised by a relapsing inflammation of the intestinal mucosal lining. Evidence from a variety of disciplines implicates the intestinal microbiota in the pathogenesis of idiopathic IBD and their complications, including pouchitis. Many studies have reported a dysbiosis in IBD, characterised by a decrease in diversity, a decreased abundance of some dominant commensal members (such as Clostridium IV and XIVa) and an increase in detrimental bacteria (such as sulphate reducing bacteria and Escherichia coli). Therapies such as prebiotics and probiotics aim to selectively manipulate the intestinal microbiota and have been evaluated as an attractive therapeutic option with few side effects. The multispecies product VSL#3 was found effective in preventing and maintaining remission in pouchitis, whereas both VSL#3 and E. coli Nissle were effective in maintaining remission in UC. A more drastic approach to restore the composition of the microbiota and correct the underlying imbalance is a faecal microbiota transplantation (FMT). FMT has been successfully applied to treat patients with even recalcitrant Clostridium difficile infection. Particularly in UC, the majority of studies suggest that FMT may be an effective treatment option although the evidence is still limited. It is anticipated that our increasing knowledge on the composition and function of the intestinal microbiota components will allow in the future for a better selection of highly performing bacteria with specific functions required for specific benefits. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/24969143/Modulating_the_microbiota_in_inflammatory_bowel_diseases:_prebiotics_probiotics_or_faecal_transplantation L2 - https://www.cambridge.org/core/product/identifier/S0029665114000639/type/journal_article DB - PRIME DP - Unbound Medicine ER -