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[Ovarian teratoma associated with anti-N-methyl-D-aspartate receptor encephalitis: a report of 5 cases and review of the literature].
Zhonghua Fu Chan Ke Za Zhi. 2014 Apr; 49(4):281-6.ZF

Abstract

OBJECTIVE

To report the clinical features of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

METHODS

The clinical information of five female patients with ovarian teratoma and anti-NMDAR encephalitis in Peking Union Medical College Hospital and Beijing Tiantan Hospital affiliated to Capital Medical University from June 2011 to May 2013 were obtained. Relevant literatures were reviewed.

RESULTS

The initial symptoms varied from respiratory prodromes or emotional incentives before the onset of psychiatric symptoms. Patients always presented with psychosis, bizarre dyskinesia and seizures. Antibodies to NMDAR in serum and cerebrospinal fluid (CSF) were positive; The psychiatric symptoms were dramatically relieved by tumor reception and immunotherapy which occurred in inverse order of symptom development. No evidence of tumor recurrence was observed during a short-time follow-up after the surgery.

CONCLUSIONS

Ovarian teratoma with anti-NMDAR encephalitis always presents with psychiatric symptoms which could be misdiagnosed as psychiatric diseases. Patients respond to tumor resection and immunotherapy.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital,Beijing 100730, China.Email: sundw1118@aliyun.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Review

Language

chi

PubMed ID

24969336

Citation

Zhou, Xingnan, et al. "[Ovarian Teratoma Associated With anti-N-methyl-D-aspartate Receptor Encephalitis: a Report of 5 Cases and Review of the Literature]." Zhonghua Fu Chan Ke Za Zhi, vol. 49, no. 4, 2014, pp. 281-6.
Zhou X, Sun D, Feng L, et al. [Ovarian teratoma associated with anti-N-methyl-D-aspartate receptor encephalitis: a report of 5 cases and review of the literature]. Zhonghua Fu Chan Ke Za Zhi. 2014;49(4):281-6.
Zhou, X., Sun, D., Feng, L., Guo, L., Ren, H., Xue, X., Liu, Z., Leng, J., Zhu, L., & Lang, J. (2014). [Ovarian teratoma associated with anti-N-methyl-D-aspartate receptor encephalitis: a report of 5 cases and review of the literature]. Zhonghua Fu Chan Ke Za Zhi, 49(4), 281-6.
Zhou X, et al. [Ovarian Teratoma Associated With anti-N-methyl-D-aspartate Receptor Encephalitis: a Report of 5 Cases and Review of the Literature]. Zhonghua Fu Chan Ke Za Zhi. 2014;49(4):281-6. PubMed PMID: 24969336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Ovarian teratoma associated with anti-N-methyl-D-aspartate receptor encephalitis: a report of 5 cases and review of the literature]. AU - Zhou,Xingnan, AU - Sun,Dawei, AU - Feng,Limin, AU - Guo,Lei, AU - Ren,Haitao, AU - Xue,Xiaowei, AU - Liu,Zhufeng, AU - Leng,Jinhua, AU - Zhu,Lan, AU - Lang,Jinghe, PY - 2014/6/28/entrez PY - 2014/6/28/pubmed PY - 2014/12/15/medline SP - 281 EP - 6 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 49 IS - 4 N2 - OBJECTIVE: To report the clinical features of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. METHODS: The clinical information of five female patients with ovarian teratoma and anti-NMDAR encephalitis in Peking Union Medical College Hospital and Beijing Tiantan Hospital affiliated to Capital Medical University from June 2011 to May 2013 were obtained. Relevant literatures were reviewed. RESULTS: The initial symptoms varied from respiratory prodromes or emotional incentives before the onset of psychiatric symptoms. Patients always presented with psychosis, bizarre dyskinesia and seizures. Antibodies to NMDAR in serum and cerebrospinal fluid (CSF) were positive; The psychiatric symptoms were dramatically relieved by tumor reception and immunotherapy which occurred in inverse order of symptom development. No evidence of tumor recurrence was observed during a short-time follow-up after the surgery. CONCLUSIONS: Ovarian teratoma with anti-NMDAR encephalitis always presents with psychiatric symptoms which could be misdiagnosed as psychiatric diseases. Patients respond to tumor resection and immunotherapy. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/24969336/[Ovarian_teratoma_associated_with_anti_N_methyl_D_aspartate_receptor_encephalitis:_a_report_of_5_cases_and_review_of_the_literature]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-567X&year=2014&vol=49&issue=4&fpage=281 DB - PRIME DP - Unbound Medicine ER -