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Relation between macular retinal ganglion cell/inner plexiform layer thickness and multifocal electroretinogram measures in experimental glaucoma.
Invest Ophthalmol Vis Sci. 2014 Jun 26; 55(7):4512-24.IO

Abstract

PURPOSE

We investigated relations between macular retinal ganglion cell plus inner plexiform layer (RGC+IPL) thickness and macular retinal function revealed by multifocal electroretinonography (mfERG) in a nonhuman primate model of experimental glaucoma.

METHODS

Retinal ganglion cell (RGC) structure and function were followed with spectral-domain optical coherence tomography (SD-OCT) and ERGs in five macaques with unilateral experimental glaucoma. Linear regression was used to study correlations in control (Con) and experimental (Exp) eyes between peripapillary retinal nerve fiber layer (RNFL) thickness, macular RGC+IPL thickness, multifocal photopic negative response (mfPhNR) and high-frequency multifocal oscillatory potentials (mfOP) in slow-sequence mfERG, and low-frequency component (mfLFC) in global-flash mfERG. We used ANOVA and paired t-tests to compare glaucoma-related mfERG changes between superior and inferior hemifields, foveal hexagon, inner three rings, and four quadrants of macula.

RESULTS

Average macular RGC+IPL and temporal RNFL thickness were strongly correlated (r(2) = 0.90, P < 0.001). In hexagon-by-hexagon analysis, all three mfERG measures were correlated (P < 0.001) with RGC+IPL thickness for Con (r(2), 0.33-0.51) and Exp eyes (r(2), 0.17-0.35). The RGC structural and functional metrics decreased as eccentricity increased. The reduction in amplitude of mfERG measures in Exp eyes relative to Con eyes was proportionally greater, in general, than the relative thinning of RGC+IPL at the same location for eyes in which structural loss was not evident, or mild to moderate. Although not statistically significant, percent amplitude reduction of mfERG measures was greatest in the inferior temporal quadrant.

CONCLUSIONS

Macular RGC+IPL thickness and mfERG measures of RGC function can be complementary tools in assessing glaucomatous neuropathy.

Authors+Show Affiliations

University of Houston, College of Optometry, Houston, Texas, United States.University of Houston, College of Optometry, Houston, Texas, United States.University of Houston, College of Optometry, Houston, Texas, United States.University of Houston, College of Optometry, Houston, Texas, United States.University of Houston, College of Optometry, Houston, Texas, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24970256

Citation

Luo, Xunda, et al. "Relation Between Macular Retinal Ganglion Cell/inner Plexiform Layer Thickness and Multifocal Electroretinogram Measures in Experimental Glaucoma." Investigative Ophthalmology & Visual Science, vol. 55, no. 7, 2014, pp. 4512-24.
Luo X, Patel NB, Rajagopalan LP, et al. Relation between macular retinal ganglion cell/inner plexiform layer thickness and multifocal electroretinogram measures in experimental glaucoma. Invest Ophthalmol Vis Sci. 2014;55(7):4512-24.
Luo, X., Patel, N. B., Rajagopalan, L. P., Harwerth, R. S., & Frishman, L. J. (2014). Relation between macular retinal ganglion cell/inner plexiform layer thickness and multifocal electroretinogram measures in experimental glaucoma. Investigative Ophthalmology & Visual Science, 55(7), 4512-24. https://doi.org/10.1167/iovs.14-13937
Luo X, et al. Relation Between Macular Retinal Ganglion Cell/inner Plexiform Layer Thickness and Multifocal Electroretinogram Measures in Experimental Glaucoma. Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4512-24. PubMed PMID: 24970256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between macular retinal ganglion cell/inner plexiform layer thickness and multifocal electroretinogram measures in experimental glaucoma. AU - Luo,Xunda, AU - Patel,Nimesh B, AU - Rajagopalan,Lakshmi P, AU - Harwerth,Ronald S, AU - Frishman,Laura J, Y1 - 2014/06/26/ PY - 2014/6/28/entrez PY - 2014/6/28/pubmed PY - 2014/9/27/medline KW - experimental glaucoma KW - multifocal ERG KW - photopic negative response KW - retinal ganglion cell + inner plexiform layer complex SP - 4512 EP - 24 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 55 IS - 7 N2 - PURPOSE: We investigated relations between macular retinal ganglion cell plus inner plexiform layer (RGC+IPL) thickness and macular retinal function revealed by multifocal electroretinonography (mfERG) in a nonhuman primate model of experimental glaucoma. METHODS: Retinal ganglion cell (RGC) structure and function were followed with spectral-domain optical coherence tomography (SD-OCT) and ERGs in five macaques with unilateral experimental glaucoma. Linear regression was used to study correlations in control (Con) and experimental (Exp) eyes between peripapillary retinal nerve fiber layer (RNFL) thickness, macular RGC+IPL thickness, multifocal photopic negative response (mfPhNR) and high-frequency multifocal oscillatory potentials (mfOP) in slow-sequence mfERG, and low-frequency component (mfLFC) in global-flash mfERG. We used ANOVA and paired t-tests to compare glaucoma-related mfERG changes between superior and inferior hemifields, foveal hexagon, inner three rings, and four quadrants of macula. RESULTS: Average macular RGC+IPL and temporal RNFL thickness were strongly correlated (r(2) = 0.90, P < 0.001). In hexagon-by-hexagon analysis, all three mfERG measures were correlated (P < 0.001) with RGC+IPL thickness for Con (r(2), 0.33-0.51) and Exp eyes (r(2), 0.17-0.35). The RGC structural and functional metrics decreased as eccentricity increased. The reduction in amplitude of mfERG measures in Exp eyes relative to Con eyes was proportionally greater, in general, than the relative thinning of RGC+IPL at the same location for eyes in which structural loss was not evident, or mild to moderate. Although not statistically significant, percent amplitude reduction of mfERG measures was greatest in the inferior temporal quadrant. CONCLUSIONS: Macular RGC+IPL thickness and mfERG measures of RGC function can be complementary tools in assessing glaucomatous neuropathy. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/24970256/Relation_between_macular_retinal_ganglion_cell/inner_plexiform_layer_thickness_and_multifocal_electroretinogram_measures_in_experimental_glaucoma_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-13937 DB - PRIME DP - Unbound Medicine ER -