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Paper spray and extraction spray mass spectrometry for the direct and simultaneous quantification of eight drugs of abuse in whole blood.
Anal Chem. 2014 Aug 05; 86(15):7712-8.AC

Abstract

Determination of eight drugs of abuse in blood has been performed using paper spray or extraction spray mass spectrometry in under 2 min with minimal sample preparation. A method has been optimized for quantification of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), morphine, cocaine, and Δ9-tetrahydrocannabinol (THC) from a single blood spot. Sample to sample variations of 1-5% relative standard deviation were achieved using stable isotope-labeled internal standards and tandem mass spectrometry. Limits of detection for all drugs were below typical physiological and toxicological levels. Paper spray and extraction spray each used less than 10 μL of whole blood. These methods exhibit the potential for performing rapid and high-throughput assays for selective on-site multicompound quantitative screening of illicit drugs.

Authors+Show Affiliations

Department of Chemistry and Center for Analytical Instrumentation, Purdue University , West Lafayette, Indiana 47907, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24970379

Citation

Espy, Ryan D., et al. "Paper Spray and Extraction Spray Mass Spectrometry for the Direct and Simultaneous Quantification of Eight Drugs of Abuse in Whole Blood." Analytical Chemistry, vol. 86, no. 15, 2014, pp. 7712-8.
Espy RD, Teunissen SF, Manicke NE, et al. Paper spray and extraction spray mass spectrometry for the direct and simultaneous quantification of eight drugs of abuse in whole blood. Anal Chem. 2014;86(15):7712-8.
Espy, R. D., Teunissen, S. F., Manicke, N. E., Ren, Y., Ouyang, Z., van Asten, A., & Cooks, R. G. (2014). Paper spray and extraction spray mass spectrometry for the direct and simultaneous quantification of eight drugs of abuse in whole blood. Analytical Chemistry, 86(15), 7712-8. https://doi.org/10.1021/ac5016408
Espy RD, et al. Paper Spray and Extraction Spray Mass Spectrometry for the Direct and Simultaneous Quantification of Eight Drugs of Abuse in Whole Blood. Anal Chem. 2014 Aug 5;86(15):7712-8. PubMed PMID: 24970379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paper spray and extraction spray mass spectrometry for the direct and simultaneous quantification of eight drugs of abuse in whole blood. AU - Espy,Ryan D, AU - Teunissen,Sebastiaan Frans, AU - Manicke,Nicholas E, AU - Ren,Yue, AU - Ouyang,Zheng, AU - van Asten,Arian, AU - Cooks,R Graham, Y1 - 2014/07/09/ PY - 2014/6/28/entrez PY - 2014/6/28/pubmed PY - 2015/8/20/medline SP - 7712 EP - 8 JF - Analytical chemistry JO - Anal Chem VL - 86 IS - 15 N2 - Determination of eight drugs of abuse in blood has been performed using paper spray or extraction spray mass spectrometry in under 2 min with minimal sample preparation. A method has been optimized for quantification of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), morphine, cocaine, and Δ9-tetrahydrocannabinol (THC) from a single blood spot. Sample to sample variations of 1-5% relative standard deviation were achieved using stable isotope-labeled internal standards and tandem mass spectrometry. Limits of detection for all drugs were below typical physiological and toxicological levels. Paper spray and extraction spray each used less than 10 μL of whole blood. These methods exhibit the potential for performing rapid and high-throughput assays for selective on-site multicompound quantitative screening of illicit drugs. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/24970379/Paper_spray_and_extraction_spray_mass_spectrometry_for_the_direct_and_simultaneous_quantification_of_eight_drugs_of_abuse_in_whole_blood_ L2 - https://doi.org/10.1021/ac5016408 DB - PRIME DP - Unbound Medicine ER -