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Effects of Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis extracts on in vitro α-glucosidase activity and glucose diffusion.
Nutr Hosp. 2014 Jun 01; 29(6):1434-46.NH

Abstract

BACKGROUND

Seaweeds are good sources of dietary fibre, which can influence glucose uptake and glycemic control.

OBJECTIVE

To investigate and compare the in vitro inhibitory activity of different extracts from Undaria pinnatifida (Wakame), Himanthalia elongata (Sea spaghetti) and Porphyra umbilicalis (Nori) on α-glucosidase activity and glucose diffusion.

METHODS

The in vitro effects Chloroform-, ethanol- and water-soluble extracts of the three algae were assayed on α- glucosidase activity and glucose diffusion through membrane. Principal Components Analysis (PCA) was applied to identify patterns in the data and to discriminate which extract will show the most proper effect.

RESULTS

Only water extracts of Sea spaghetti possessed significant in vitro inhibitory effects on α-glucosidase activity (26.2% less mmol/L glucose production than control, p < 0.05) at 75 min. PCA distinguished Sea spaghetti effects, supporting that soluble fibre and polyphenols were involved. After 6 h, Ethanol-Sea spaghetti and water-Wakame extracts exerted the highest inhibitory effects on glucose diffusion (65.0% and 60.2% vs control, respectively). This extracts displayed the lowest slopes for glucose diffusion-time lineal adjustments (68.2% and 62.8% vs control, respectively).

CONCLUSIONS

The seaweed hypoglycemic effects appear multi-faceted and not necessarily concatenated. According to present results, ethanol and water extracts of Sea spaghetti, and water extracts of Wakame could be useful for the development of functional foods with specific hypoglycemic properties.

Authors+Show Affiliations

Departamento de Nutrición y Bromatología I (Nutrición); Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n. 28040-Madrid. Spain;.Departamento de Nutrición y Bromatología I (Nutrición); Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n. 28040-Madrid. Spain; Departamento de Farmacología; Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n. 28040-Madrid. Spain.Departamento de Nutrición y Bromatología I (Nutrición); Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n. 28040-Madrid. Spain;.Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN, CSIC). José Antonio Novais 10, Ciudad Universitaria, 28040-Madrid, Spain..Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN, CSIC). José Antonio Novais 10, Ciudad Universitaria, 28040-Madrid, Spain..Institute for Global Food Security; Biological Sciences, Queen's University, Belfast BT9 5AG, Northern Ireland, UK..Institute for Global Food Security; Biological Sciences, Queen's University, Belfast BT9 5AG, Northern Ireland, UK..Departamento de Nutrición y Bromatología I (Nutrición); Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n. 28040-Madrid. Spain;. frasan@ucm.es.Departamento de Farmacología; Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n. 28040-Madrid. Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24972485

Citation

Schultz Moreira, Adriana R., et al. "Effects of Undaria Pinnatifida, Himanthalia Elongata and Porphyra Umbilicalis Extracts On in Vitro Α-glucosidase Activity and Glucose Diffusion." Nutricion Hospitalaria, vol. 29, no. 6, 2014, pp. 1434-46.
Schultz Moreira AR, Garcimartín A, Bastida S, et al. Effects of Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis extracts on in vitro α-glucosidase activity and glucose diffusion. Nutr Hosp. 2014;29(6):1434-46.
Schultz Moreira, A. R., Garcimartín, A., Bastida, S., Jiménez-Escrig, A., Rupérez, P., Green, B. D., Rafferty, E., Sánchez-Muniz, F. J., & Benedí, J. (2014). Effects of Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis extracts on in vitro α-glucosidase activity and glucose diffusion. Nutricion Hospitalaria, 29(6), 1434-46. https://doi.org/10.3305/nh.2014.29.6.7381
Schultz Moreira AR, et al. Effects of Undaria Pinnatifida, Himanthalia Elongata and Porphyra Umbilicalis Extracts On in Vitro Α-glucosidase Activity and Glucose Diffusion. Nutr Hosp. 2014 Jun 1;29(6):1434-46. PubMed PMID: 24972485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis extracts on in vitro α-glucosidase activity and glucose diffusion. AU - Schultz Moreira,Adriana R, AU - Garcimartín,Alba, AU - Bastida,Sara, AU - Jiménez-Escrig,Antonio, AU - Rupérez,Pilar, AU - Green,Brian D, AU - Rafferty,Eamon, AU - Sánchez-Muniz,Francisco J, AU - Benedí,Juana, Y1 - 2014/06/01/ PY - 2014/6/29/entrez PY - 2014/6/29/pubmed PY - 2015/10/23/medline SP - 1434 EP - 46 JF - Nutricion hospitalaria JO - Nutr Hosp VL - 29 IS - 6 N2 - BACKGROUND: Seaweeds are good sources of dietary fibre, which can influence glucose uptake and glycemic control. OBJECTIVE: To investigate and compare the in vitro inhibitory activity of different extracts from Undaria pinnatifida (Wakame), Himanthalia elongata (Sea spaghetti) and Porphyra umbilicalis (Nori) on α-glucosidase activity and glucose diffusion. METHODS: The in vitro effects Chloroform-, ethanol- and water-soluble extracts of the three algae were assayed on α- glucosidase activity and glucose diffusion through membrane. Principal Components Analysis (PCA) was applied to identify patterns in the data and to discriminate which extract will show the most proper effect. RESULTS: Only water extracts of Sea spaghetti possessed significant in vitro inhibitory effects on α-glucosidase activity (26.2% less mmol/L glucose production than control, p < 0.05) at 75 min. PCA distinguished Sea spaghetti effects, supporting that soluble fibre and polyphenols were involved. After 6 h, Ethanol-Sea spaghetti and water-Wakame extracts exerted the highest inhibitory effects on glucose diffusion (65.0% and 60.2% vs control, respectively). This extracts displayed the lowest slopes for glucose diffusion-time lineal adjustments (68.2% and 62.8% vs control, respectively). CONCLUSIONS: The seaweed hypoglycemic effects appear multi-faceted and not necessarily concatenated. According to present results, ethanol and water extracts of Sea spaghetti, and water extracts of Wakame could be useful for the development of functional foods with specific hypoglycemic properties. SN - 1699-5198 UR - https://www.unboundmedicine.com/medline/citation/24972485/Effects_of_Undaria_pinnatifida_Himanthalia_elongata_and_Porphyra_umbilicalis_extracts_on_in_vitro_α_glucosidase_activity_and_glucose_diffusion_ L2 - http://www.aulamedica.es/nh/pdf/7381.pdf DB - PRIME DP - Unbound Medicine ER -