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Synthetic cathinones: "a khat and mouse game".
Toxicol Lett. 2014 Sep 02; 229(2):349-56.TL

Abstract

The birth of the twenty first century has provoked a substantial rise in the use of designer drugs, such as synthetic cathinones, because of a decrease in the availability and purity of other drugs of abuse. The khat plant or Catha edulis, contains cathinone, the parent compound. Synthetic cathinones are sold under the name "bath salts" as a ploy to circumvent legislation from banning their use. Constant modification of the chemical structure by covert laboratories allows manufacturers to stay one step ahead of the legal process. Currently, the widespread distribution of "bath salts" has negative consequences for law enforcement officials and public health resources. Comparable mechanisms of action, between the synthetic cathinones and amphetamine, cocaine, and MDMA are attributed to the similarities in their chemical structures. Synthetic cathinone's potent stimulatory effects, coupled with their high abuse potential, and propensity for addiction demands additional pharmacological and toxicological evaluations for these existing and new designer drugs of abuse. If these drugs are designed carefully, they might also have a significant therapeutic value.

Authors+Show Affiliations

Department of Drug Discovery and Development, Auburn University, Auburn, AL 36830, USA.Department of Drug Discovery and Development, Auburn University, Auburn, AL 36830, USA.Department of Drug Discovery and Development, Auburn University, Auburn, AL 36830, USA.Department of Drug Discovery and Development, Auburn University, Auburn, AL 36830, USA.Department of Drug Discovery and Development, Auburn University, Auburn, AL 36830, USA.Department of Drug Discovery and Development, Auburn University, Auburn, AL 36830, USA.Department of Drug Discovery and Development, Auburn University, Auburn, AL 36830, USA. Electronic address: dhanamu@auburn.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24973490

Citation

Katz, Daniel P., et al. "Synthetic Cathinones: "a Khat and Mouse Game"." Toxicology Letters, vol. 229, no. 2, 2014, pp. 349-56.
Katz DP, Bhattacharya D, Bhattacharya S, et al. Synthetic cathinones: "a khat and mouse game". Toxicol Lett. 2014;229(2):349-56.
Katz, D. P., Bhattacharya, D., Bhattacharya, S., Deruiter, J., Clark, C. R., Suppiramaniam, V., & Dhanasekaran, M. (2014). Synthetic cathinones: "a khat and mouse game". Toxicology Letters, 229(2), 349-56. https://doi.org/10.1016/j.toxlet.2014.06.020
Katz DP, et al. Synthetic Cathinones: "a Khat and Mouse Game". Toxicol Lett. 2014 Sep 2;229(2):349-56. PubMed PMID: 24973490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthetic cathinones: "a khat and mouse game". AU - Katz,Daniel P, AU - Bhattacharya,Dwipayan, AU - Bhattacharya,Subhrajit, AU - Deruiter,Jack, AU - Clark,C Randall, AU - Suppiramaniam,Vishnu, AU - Dhanasekaran,Muralikrishnan, Y1 - 2014/06/25/ PY - 2014/05/02/received PY - 2014/06/09/revised PY - 2014/06/10/accepted PY - 2014/6/29/entrez PY - 2014/6/29/pubmed PY - 2014/10/2/medline KW - Addiction KW - Bath salts KW - Designer drug KW - MDPV KW - Stimulant KW - Synthetic cathinone SP - 349 EP - 56 JF - Toxicology letters JO - Toxicol Lett VL - 229 IS - 2 N2 - The birth of the twenty first century has provoked a substantial rise in the use of designer drugs, such as synthetic cathinones, because of a decrease in the availability and purity of other drugs of abuse. The khat plant or Catha edulis, contains cathinone, the parent compound. Synthetic cathinones are sold under the name "bath salts" as a ploy to circumvent legislation from banning their use. Constant modification of the chemical structure by covert laboratories allows manufacturers to stay one step ahead of the legal process. Currently, the widespread distribution of "bath salts" has negative consequences for law enforcement officials and public health resources. Comparable mechanisms of action, between the synthetic cathinones and amphetamine, cocaine, and MDMA are attributed to the similarities in their chemical structures. Synthetic cathinone's potent stimulatory effects, coupled with their high abuse potential, and propensity for addiction demands additional pharmacological and toxicological evaluations for these existing and new designer drugs of abuse. If these drugs are designed carefully, they might also have a significant therapeutic value. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/24973490/Synthetic_cathinones:_"a_khat_and_mouse_game"_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(14)00265-3 DB - PRIME DP - Unbound Medicine ER -