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Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial.

Abstract

BACKGROUND & AIMS

We are aware of no study that examined the effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes (GDM). This study was designed to assess the effects of omega-3 fatty acid supplementation on insulin concentrations and lipid profiles among pregnant women with GDM.

METHODS

This randomized, double-blind, placebo-controlled clinical trial was performed among 56 women with GDM. Subjects were randomly assigned to receive either 1000 mg omega-3 fatty acid supplements containing 180 mg eicosapentaenoic acid and 120 mg docosahexanoic acid (n = 28) or placebo (n = 28) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables.

RESULTS

Although omega-3 fatty acid supplementation did not led to a significant change in serum insulin levels and HOMA-IR in omega-3 fatty acid group, we found a significant difference in changes in serum insulin levels (change from baseline: -1.5 ± 7.5 vs. +3.5 ± 8.5 μIU/mL, P = 0.02) and HOMA-IR (-0.4 ± 2.1 vs. +1.1 ± 2.4, P = 0.02) comparing the two groups. Furthermore, a significant reduction in serum high sensitivity C-reactive protein (hs-CRP) levels was seen after omega-3 fatty acid supplementation compared with placebo (-236.3 ± 1541.9 vs. 898.6 ± 2292.7 ng/mL, P = 0.03). Omega-3 fatty acid supplementation did not influence fasting plasma glucose, homeostatic model assessment-Beta cell function (HOMA-B), quantitative insulin sensitivity check index (QUICKI) and lipid profiles.

CONCLUSIONS

Omega-3 fatty acid supplementation in GDM women had beneficial effects on insulin resistance, however, it did not affect plasma glucose, HOMA-B, QUICKI and lipid profiles. Clinical registration number: www.irct.ir as IRCT201312265623N16.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

    ,

    Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

    ,

    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: asemi_r@yahoo.com.

    Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

    Source

    MeSH

    Adolescent
    Adult
    Antioxidants
    Blood Glucose
    Body Mass Index
    Body Weight
    C-Reactive Protein
    Cholesterol, HDL
    Cholesterol, LDL
    Diabetes, Gestational
    Dietary Supplements
    Double-Blind Method
    Fasting
    Fatty Acids, Omega-3
    Female
    Humans
    Insulin
    Insulin Resistance
    Iran
    Pregnancy
    Triglycerides
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    24973862

    Citation

    Samimi, Mansooreh, et al. "Effects of Omega-3 Fatty Acid Supplementation On Insulin Metabolism and Lipid Profiles in Gestational Diabetes: Randomized, Double-blind, Placebo-controlled Trial." Clinical Nutrition (Edinburgh, Scotland), vol. 34, no. 3, 2015, pp. 388-93.
    Samimi M, Jamilian M, Asemi Z, et al. Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Clin Nutr. 2015;34(3):388-93.
    Samimi, M., Jamilian, M., Asemi, Z., & Esmaillzadeh, A. (2015). Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Clinical Nutrition (Edinburgh, Scotland), 34(3), pp. 388-93. doi:10.1016/j.clnu.2014.06.005.
    Samimi M, et al. Effects of Omega-3 Fatty Acid Supplementation On Insulin Metabolism and Lipid Profiles in Gestational Diabetes: Randomized, Double-blind, Placebo-controlled Trial. Clin Nutr. 2015;34(3):388-93. PubMed PMID: 24973862.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial. AU - Samimi,Mansooreh, AU - Jamilian,Mehri, AU - Asemi,Zatollah, AU - Esmaillzadeh,Ahmad, Y1 - 2014/06/17/ PY - 2014/05/02/received PY - 2014/06/08/revised PY - 2014/06/11/accepted PY - 2014/6/30/entrez PY - 2014/6/30/pubmed PY - 2016/2/24/medline KW - Gestational diabetes KW - Omega-3 fatty acid KW - Pregnant women KW - Supplementation SP - 388 EP - 93 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 34 IS - 3 N2 - BACKGROUND & AIMS: We are aware of no study that examined the effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes (GDM). This study was designed to assess the effects of omega-3 fatty acid supplementation on insulin concentrations and lipid profiles among pregnant women with GDM. METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed among 56 women with GDM. Subjects were randomly assigned to receive either 1000 mg omega-3 fatty acid supplements containing 180 mg eicosapentaenoic acid and 120 mg docosahexanoic acid (n = 28) or placebo (n = 28) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables. RESULTS: Although omega-3 fatty acid supplementation did not led to a significant change in serum insulin levels and HOMA-IR in omega-3 fatty acid group, we found a significant difference in changes in serum insulin levels (change from baseline: -1.5 ± 7.5 vs. +3.5 ± 8.5 μIU/mL, P = 0.02) and HOMA-IR (-0.4 ± 2.1 vs. +1.1 ± 2.4, P = 0.02) comparing the two groups. Furthermore, a significant reduction in serum high sensitivity C-reactive protein (hs-CRP) levels was seen after omega-3 fatty acid supplementation compared with placebo (-236.3 ± 1541.9 vs. 898.6 ± 2292.7 ng/mL, P = 0.03). Omega-3 fatty acid supplementation did not influence fasting plasma glucose, homeostatic model assessment-Beta cell function (HOMA-B), quantitative insulin sensitivity check index (QUICKI) and lipid profiles. CONCLUSIONS: Omega-3 fatty acid supplementation in GDM women had beneficial effects on insulin resistance, however, it did not affect plasma glucose, HOMA-B, QUICKI and lipid profiles. Clinical registration number: www.irct.ir as IRCT201312265623N16. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/24973862/Effects_of_omega_3_fatty_acid_supplementation_on_insulin_metabolism_and_lipid_profiles_in_gestational_diabetes:_Randomized_double_blind_placebo_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(14)00169-1 DB - PRIME DP - Unbound Medicine ER -